Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction

A reverse micellar was modified by combining the anionic AOT and zwitterionic lauryl sulfobetaine surfactant for the extraction of erythromycin was proposed for the first time as a new approach for antibiotic extraction. The stability of the mixed reverse micelle was evaluated in terms of the critic...

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Main Authors:	Siti Norazimah, Mohamad-Aziz, Zularisam, A. W., Mimi Sakinah, A. M.
Format:	Article
Language:	English
Published:	Elsevier 2019
Subjects:	Q Science (General) QD Chemistry T Technology (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/25164/ http://umpir.ump.edu.my/id/eprint/25164/ http://umpir.ump.edu.my/id/eprint/25164/ http://umpir.ump.edu.my/id/eprint/25164/1/journal%20accepted%203.pdf

id	ump-25164
recordtype	eprints
spelling	ump-251642019-10-24T08:31:31Z http://umpir.ump.edu.my/id/eprint/25164/ Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction Siti Norazimah, Mohamad-Aziz Zularisam, A. W. Mimi Sakinah, A. M. Q Science (General) QD Chemistry T Technology (General) A reverse micellar was modified by combining the anionic AOT and zwitterionic lauryl sulfobetaine surfactant for the extraction of erythromycin was proposed for the first time as a new approach for antibiotic extraction. The stability of the mixed reverse micelle was evaluated in terms of the critical micelle concentration (CMC) using the Wilhelmy Ring method, as well as the thermodynamic properties prior to extraction. The effect of parameters such as AOT concentration, lauryl sulfobetaine fraction and pH of the aqueous phase was investigated during forward extraction. Isopropanol volume percent (%), NaCl concentration, and pH of aqueous phase were investigated during backward extraction. The thermodynamic analysis confirmed the stability of the mixed AOT/lauryl sulfobetaine reverse micelle with a positive synergistic effect. The surface activity was enhanced, by which the CMC of the mixed reverse micelle was significantly lowered, ranging from 0.7 to 5.7 g/L. The overall thermodynamic data comprising ΔGm (between -15.44 to -20.24 kJ/mol), ΔGads (between -27.03 to -28.97 kJ/mol), and ΔGo ex (range between -0.39 to 8.87 kJ/mol) are affirmative that micellization was spontaneous. Erythromycin was also found to be interfacially active at all tested condition. The highest erythromycin solubilisation (94.2%) was achieved, even with low AOT surfactant (60.0 g/L) which reflects the synergy between AOT and lauryl sulfobetaine. In addition, in the absence of isopropanol, erythromycin was found to be successfully recovered during the backward extraction. However, isopropanol is still considered as a recovery booster which enables higher erythromycin recovery. Elsevier 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25164/1/journal%20accepted%203.pdf Siti Norazimah, Mohamad-Aziz and Zularisam, A. W. and Mimi Sakinah, A. M. (2019) Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction. Separation and Purification Technology, 229. pp. 1-42. ISSN 1383-5866 http://doi.org/10.1016/j.seppur.2019.115816 doi: https://doi.org/10.1016/j.seppur.2019.115816
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General) QD Chemistry T Technology (General)
spellingShingle	Q Science (General) QD Chemistry T Technology (General) Siti Norazimah, Mohamad-Aziz Zularisam, A. W. Mimi Sakinah, A. M. Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
description	A reverse micellar was modified by combining the anionic AOT and zwitterionic lauryl sulfobetaine surfactant for the extraction of erythromycin was proposed for the first time as a new approach for antibiotic extraction. The stability of the mixed reverse micelle was evaluated in terms of the critical micelle concentration (CMC) using the Wilhelmy Ring method, as well as the thermodynamic properties prior to extraction. The effect of parameters such as AOT concentration, lauryl sulfobetaine fraction and pH of the aqueous phase was investigated during forward extraction. Isopropanol volume percent (%), NaCl concentration, and pH of aqueous phase were investigated during backward extraction. The thermodynamic analysis confirmed the stability of the mixed AOT/lauryl sulfobetaine reverse micelle with a positive synergistic effect. The surface activity was enhanced, by which the CMC of the mixed reverse micelle was significantly lowered, ranging from 0.7 to 5.7 g/L. The overall thermodynamic data comprising ΔGm (between -15.44 to -20.24 kJ/mol), ΔGads (between -27.03 to -28.97 kJ/mol), and ΔGo ex (range between -0.39 to 8.87 kJ/mol) are affirmative that micellization was spontaneous. Erythromycin was also found to be interfacially active at all tested condition. The highest erythromycin solubilisation (94.2%) was achieved, even with low AOT surfactant (60.0 g/L) which reflects the synergy between AOT and lauryl sulfobetaine. In addition, in the absence of isopropanol, erythromycin was found to be successfully recovered during the backward extraction. However, isopropanol is still considered as a recovery booster which enables higher erythromycin recovery.
format	Article
author	Siti Norazimah, Mohamad-Aziz Zularisam, A. W. Mimi Sakinah, A. M.
author_facet	Siti Norazimah, Mohamad-Aziz Zularisam, A. W. Mimi Sakinah, A. M.
author_sort	Siti Norazimah, Mohamad-Aziz
title	Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_short	Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_full	Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_fullStr	Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_full_unstemmed	Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_sort	reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
publisher	Elsevier
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/25164/ http://umpir.ump.edu.my/id/eprint/25164/ http://umpir.ump.edu.my/id/eprint/25164/ http://umpir.ump.edu.my/id/eprint/25164/1/journal%20accepted%203.pdf
first_indexed	2023-09-18T22:38:30Z
last_indexed	2023-09-18T22:38:30Z
_version_	1777416756516618240

Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction

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