Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering
Aim: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Future Medicine Ltd.
2019
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/24997/ http://umpir.ump.edu.my/id/eprint/24997/ http://umpir.ump.edu.my/id/eprint/24997/ http://umpir.ump.edu.my/id/eprint/24997/1/Functionalized%20core_shell%20nanofibers%20for%20the.pdf |
| Summary: | Aim: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develop vascular grafts. Materials & methods: The fabricated core/shell nanofibers contained polycaprolactone/gelatin as the shell, and silk fibroin/VEGF as the core materials. Results: The results observed that the core/shell nanofibers interact to differentiate MSCs into smooth muscle cells by the expression of vascular smooth muscle cell (VSMC) contractile proteins α-actinin, myosin and F-actin. Conclusion: The functionalized polycaprolactone/gelatin/silk fibroin/VEGF (250 ng) core/shell nanofibers were fabricated for the controlled release of VEGF in a persistent manner for the differentiation of MSCs into smooth muscle cells for vascular tissue engineering. |
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