Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin

In the present study, the reverse micelle of anionic (sodium bis(2-ethylhexyl) sulfosuccinate) (AOT) and zwitterionic (3-N, N-Dimethyllaurylammonio propanesulfonate) (SB3–12) surfactants was mixed in an isooctane organic phase, and their behaviour towards solubilisation of erythromycin was investiga...

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Main Authors:	Siti Norazimah, Mohamad Aziz, Mishra, Puranjan, Zularisam, A. W., Mimi Sakinah, A. M.
Format:	Article
Language:	English
Published:	Elsevier 2019
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/24899/ http://umpir.ump.edu.my/id/eprint/24899/ http://umpir.ump.edu.my/id/eprint/24899/ http://umpir.ump.edu.my/id/eprint/24899/1/Isooctane.pdf

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recordtype	eprints
spelling	ump-248992019-05-10T03:12:45Z http://umpir.ump.edu.my/id/eprint/24899/ Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin Siti Norazimah, Mohamad Aziz Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. TP Chemical technology In the present study, the reverse micelle of anionic (sodium bis(2-ethylhexyl) sulfosuccinate) (AOT) and zwitterionic (3-N, N-Dimethyllaurylammonio propanesulfonate) (SB3–12) surfactants was mixed in an isooctane organic phase, and their behaviour towards solubilisation of erythromycin was investigated. Erythromycin is used as an alternative for gram-positive infections in patients resistant to, or allergic to penicillin for skin treatment, soft tissue infection, mycoplasma pneumonia and legionella disease. The critical micelle concentration of the mixture (CMCmix) was analysed by applying phase separation and Rubingh's model of the surfactants to evaluate the synergistic effect between AOT and SB3–12 in isooctane solution. The critical micelle concentration of AOT and SB3–12 was 22.5 g/L and 0.9 g/L, respectively in isooctane phase. The critical micelle concentration of the mixed AOT/SB3–12 reverse micelle was 0.70 g/L. The mixed reverse micelle has efficiently increased the solubility of erythromycin, by which 94.2% transfer was achieved from 0.8:0.2 proportion of AOT to SB3–12. Thermodynamic parameters describing the free energy of micelle formation (ΔGm) and standard Gibbs free energy of adsorption (ΔGads) were found to be negative which suggest that micellization and adsorption were spontaneous. The excess Gibbs free energy of mixing (ΔGoex) value indicates that the formation of the AOT/SB3–12 mixed reverse micelle was thermodynamically stable. Conclusively, the mixed reverse micelle enhances erythromycin solubilisation in isooctane organic phase at low surfactant concentration, and the synergism of the combination between AOT and SB3–12 was positive. Elsevier 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24899/1/Isooctane.pdf Siti Norazimah, Mohamad Aziz and Mishra, Puranjan and Zularisam, A. W. and Mimi Sakinah, A. M. (2019) Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin. Journal of Molecular Liquids. pp. 1-45. ISSN 0167-7322 (In Press) https://doi.org/10.1016/j.molliq.2019.110882 https://doi.org/10.1016/j.molliq.2019.110882
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Siti Norazimah, Mohamad Aziz Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin
description	In the present study, the reverse micelle of anionic (sodium bis(2-ethylhexyl) sulfosuccinate) (AOT) and zwitterionic (3-N, N-Dimethyllaurylammonio propanesulfonate) (SB3–12) surfactants was mixed in an isooctane organic phase, and their behaviour towards solubilisation of erythromycin was investigated. Erythromycin is used as an alternative for gram-positive infections in patients resistant to, or allergic to penicillin for skin treatment, soft tissue infection, mycoplasma pneumonia and legionella disease. The critical micelle concentration of the mixture (CMCmix) was analysed by applying phase separation and Rubingh's model of the surfactants to evaluate the synergistic effect between AOT and SB3–12 in isooctane solution. The critical micelle concentration of AOT and SB3–12 was 22.5 g/L and 0.9 g/L, respectively in isooctane phase. The critical micelle concentration of the mixed AOT/SB3–12 reverse micelle was 0.70 g/L. The mixed reverse micelle has efficiently increased the solubility of erythromycin, by which 94.2% transfer was achieved from 0.8:0.2 proportion of AOT to SB3–12. Thermodynamic parameters describing the free energy of micelle formation (ΔGm) and standard Gibbs free energy of adsorption (ΔGads) were found to be negative which suggest that micellization and adsorption were spontaneous. The excess Gibbs free energy of mixing (ΔGoex) value indicates that the formation of the AOT/SB3–12 mixed reverse micelle was thermodynamically stable. Conclusively, the mixed reverse micelle enhances erythromycin solubilisation in isooctane organic phase at low surfactant concentration, and the synergism of the combination between AOT and SB3–12 was positive.
format	Article
author	Siti Norazimah, Mohamad Aziz Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M.
author_facet	Siti Norazimah, Mohamad Aziz Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M.
author_sort	Siti Norazimah, Mohamad Aziz
title	Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin
title_short	Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin
title_full	Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin
title_fullStr	Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin
title_full_unstemmed	Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin
title_sort	isooctane-based anionic and zwitterionic surfactant: synergistic interaction of mixed reverse micelle and solubilisation of erythromycin
publisher	Elsevier
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/24899/ http://umpir.ump.edu.my/id/eprint/24899/ http://umpir.ump.edu.my/id/eprint/24899/ http://umpir.ump.edu.my/id/eprint/24899/1/Isooctane.pdf
first_indexed	2023-09-18T22:37:56Z
last_indexed	2023-09-18T22:37:56Z
_version_	1777416720767516672

Isooctane-based anionic and zwitterionic surfactant: Synergistic interaction of mixed reverse micelle and solubilisation of erythromycin

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