Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering

This study is focusing to develop a porous biocompatible scaffold using hydroxyethyl cellulose (HEC) and poly (vinyl alcohol) (PVA) with improved cellular adhesion profiles and stability. The combination of HEC and PVA were synthesized using freeze-drying technique and characterized using SEM, ATR-F...

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Main Authors:	Farah Hanani, Zulkifli, Jahir Hussain, Fathima Shahitha, W. S., Wan Harun, M. M., Yusoff
Format:	Article
Language:	English
Published:	Elsevier Ltd 2019
Subjects:	Q Science (General) TJ Mechanical engineering and machinery
Online Access:	http://umpir.ump.edu.my/id/eprint/24410/ http://umpir.ump.edu.my/id/eprint/24410/ http://umpir.ump.edu.my/id/eprint/24410/ http://umpir.ump.edu.my/id/eprint/24410/1/Highly%20porous%20of%20hydroxyethyl%20cellulose%20biocomposite%20scaffolds%20for%20tissue%20engineering.pdf

id	ump-24410
recordtype	eprints
spelling	ump-244102019-03-19T04:51:47Z http://umpir.ump.edu.my/id/eprint/24410/ Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha W. S., Wan Harun M. M., Yusoff Q Science (General) TJ Mechanical engineering and machinery This study is focusing to develop a porous biocompatible scaffold using hydroxyethyl cellulose (HEC) and poly (vinyl alcohol) (PVA) with improved cellular adhesion profiles and stability. The combination of HEC and PVA were synthesized using freeze-drying technique and characterized using SEM, ATR-FTIR, TGA, DSC, and UTM. Pore size of HEC/PVA (2–40 μm) scaffolds showed diameter in a range of both pure HEC (2–20 μm) and PVA (14–70 μm). All scaffolds revealed high porosity above 85%. The water uptake of HEC was controlled by PVA cooperation in the polymer matrix. After 7 days, all blended scaffolds showed low degradation rate with the increased of PVA composition. The FTIR and TGA results explicit possible chemical interactions and mass loss of blended scaffolds, respectively. The Tg values of DSC curved in range of HEC and PVA represented the miscibility of HEC/PVA blend polymers. Higher Young's modulus was obtained with the increasing of HEC value. Cell-scaffolds interaction demonstrated that human fibroblast (hFB) cells adhered to polymer matrices with better cell proliferation observed after 7 days of cultivation. These results suggested that biocompatible of HEC/PVA scaffolds fabricated by freeze-drying method might be suitable for skin tissue engineering applications. Elsevier Ltd 2019-02 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24410/1/Highly%20porous%20of%20hydroxyethyl%20cellulose%20biocomposite%20scaffolds%20for%20tissue%20engineering.pdf Farah Hanani, Zulkifli and Jahir Hussain, Fathima Shahitha and W. S., Wan Harun and M. M., Yusoff (2019) Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering. International Journal of Biological Macromolecules, 122. pp. 562-571. ISSN 0141-8130 https://www.sciencedirect.com/science/article/pii/S0141813018333579 https://doi.org/10.1016/j.ijbiomac.2018.10.156
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General) TJ Mechanical engineering and machinery
spellingShingle	Q Science (General) TJ Mechanical engineering and machinery Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha W. S., Wan Harun M. M., Yusoff Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
description	This study is focusing to develop a porous biocompatible scaffold using hydroxyethyl cellulose (HEC) and poly (vinyl alcohol) (PVA) with improved cellular adhesion profiles and stability. The combination of HEC and PVA were synthesized using freeze-drying technique and characterized using SEM, ATR-FTIR, TGA, DSC, and UTM. Pore size of HEC/PVA (2–40 μm) scaffolds showed diameter in a range of both pure HEC (2–20 μm) and PVA (14–70 μm). All scaffolds revealed high porosity above 85%. The water uptake of HEC was controlled by PVA cooperation in the polymer matrix. After 7 days, all blended scaffolds showed low degradation rate with the increased of PVA composition. The FTIR and TGA results explicit possible chemical interactions and mass loss of blended scaffolds, respectively. The Tg values of DSC curved in range of HEC and PVA represented the miscibility of HEC/PVA blend polymers. Higher Young's modulus was obtained with the increasing of HEC value. Cell-scaffolds interaction demonstrated that human fibroblast (hFB) cells adhered to polymer matrices with better cell proliferation observed after 7 days of cultivation. These results suggested that biocompatible of HEC/PVA scaffolds fabricated by freeze-drying method might be suitable for skin tissue engineering applications.
format	Article
author	Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha W. S., Wan Harun M. M., Yusoff
author_facet	Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha W. S., Wan Harun M. M., Yusoff
author_sort	Farah Hanani, Zulkifli
title	Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
title_short	Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
title_full	Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
title_fullStr	Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
title_full_unstemmed	Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
title_sort	highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
publisher	Elsevier Ltd
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/24410/ http://umpir.ump.edu.my/id/eprint/24410/ http://umpir.ump.edu.my/id/eprint/24410/ http://umpir.ump.edu.my/id/eprint/24410/1/Highly%20porous%20of%20hydroxyethyl%20cellulose%20biocomposite%20scaffolds%20for%20tissue%20engineering.pdf
first_indexed	2023-09-18T22:36:55Z
last_indexed	2023-09-18T22:36:55Z
_version_	1777416657308745728

Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering

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