Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal

Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal

Co-crystallization is a method in formulation of drug products which is believed to improve drugs solubility, stability and dissolution rate while maintaining the biological functions of its chemical properties. In this work, the carbamazepine-saccharin (CBZ-SAC) co-crystal formation using varies mo...

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Main Authors: Syarifah, Abd Rahim, Nur Amanina, Mohamad Adaris
Format: Conference or Workshop Item
Language:English
Published: Elsevier Ltd 2018
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/24095/
http://umpir.ump.edu.my/id/eprint/24095/
http://umpir.ump.edu.my/id/eprint/24095/1/Effect%20of%20crystallization%20method%20on%20the%20formation%20of%20carbamazepine.pdf
id ump-24095
recordtype eprints
spelling ump-240952019-02-01T06:49:10Z http://umpir.ump.edu.my/id/eprint/24095/ Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal Syarifah, Abd Rahim Nur Amanina, Mohamad Adaris TP Chemical technology Co-crystallization is a method in formulation of drug products which is believed to improve drugs solubility, stability and dissolution rate while maintaining the biological functions of its chemical properties. In this work, the carbamazepine-saccharin (CBZ-SAC) co-crystal formation using varies mol ratio of SAC to CBZ, ethyl acetate and formic acid as a solvent and two methods was studied. The physical characterization of the co-crystal was characterized using x-ray diffraction (XRD) powder and differential scanning calorimetry (DSC). The XRD pattern profile analysis had confirm that the CBZ-SAC co-crystal was successfully formed only in ethyl acetate solvent for both of the screening methods applied. The findings also revealed that two polymorphic forms of CBZ-SAC co-crystal was formed during the study Elsevier Ltd 2018 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24095/1/Effect%20of%20crystallization%20method%20on%20the%20formation%20of%20carbamazepine.pdf Syarifah, Abd Rahim and Nur Amanina, Mohamad Adaris (2018) Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal. In: 3rd International Conference on Green Chemical Engineering and Technology: Materials Science, GCET 2017, 7-8 November 2017 , Melaka, Malaysia. pp. 22074-22079., 5 (10). ISSN 22147853 https://doi.org/10.1016/j.matpr.2018.07.071
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Syarifah, Abd Rahim
Nur Amanina, Mohamad Adaris
Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal
description Co-crystallization is a method in formulation of drug products which is believed to improve drugs solubility, stability and dissolution rate while maintaining the biological functions of its chemical properties. In this work, the carbamazepine-saccharin (CBZ-SAC) co-crystal formation using varies mol ratio of SAC to CBZ, ethyl acetate and formic acid as a solvent and two methods was studied. The physical characterization of the co-crystal was characterized using x-ray diffraction (XRD) powder and differential scanning calorimetry (DSC). The XRD pattern profile analysis had confirm that the CBZ-SAC co-crystal was successfully formed only in ethyl acetate solvent for both of the screening methods applied. The findings also revealed that two polymorphic forms of CBZ-SAC co-crystal was formed during the study
format Conference or Workshop Item
author Syarifah, Abd Rahim
Nur Amanina, Mohamad Adaris
author_facet Syarifah, Abd Rahim
Nur Amanina, Mohamad Adaris
author_sort Syarifah, Abd Rahim
title Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal
title_short Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal
title_full Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal
title_fullStr Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal
title_full_unstemmed Effect of crystallization method on the formation of carbamazepine-saccharin co-crystal
title_sort effect of crystallization method on the formation of carbamazepine-saccharin co-crystal
publisher Elsevier Ltd
publishDate 2018
url http://umpir.ump.edu.my/id/eprint/24095/
http://umpir.ump.edu.my/id/eprint/24095/
http://umpir.ump.edu.my/id/eprint/24095/1/Effect%20of%20crystallization%20method%20on%20the%20formation%20of%20carbamazepine.pdf
first_indexed 2023-09-18T22:36:18Z
last_indexed 2023-09-18T22:36:18Z
_version_ 1777416618129752064

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