Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts

Far-flung evolution in tissue engineering enabled the development of bioactive and biodegradable materials to generate biocomposite nanofibrous scaffolds for bone repair and replacement therapies. Polymeric bioactive nanofibers are to biomimic the native extracellular matrix (ECM), delivering tremen...

Full description

Bibliographic Details
Main Authors:	Gnaneshwar, Puvala Vijayakumar, Sudakaran, Shruthi Vathaluru, Abisegapriyan, Sivasubramanian, Sherine, Jositta, Ramakrishna, Seeram, Mohd Fadzil, Abdul Rahim, M. M., Yusoff, Rajan, Jose, Venugopal, J.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2019
Subjects:	QD Chemistry QL Zoology RZ Other systems of medicine
Online Access:	http://umpir.ump.edu.my/id/eprint/24003/ http://umpir.ump.edu.my/id/eprint/24003/ http://umpir.ump.edu.my/id/eprint/24003/ http://umpir.ump.edu.my/id/eprint/24003/1/Ramificationofzincoxidedopedhydroxyapatite1.pdf

id	ump-24003
recordtype	eprints
spelling	ump-240032019-05-30T08:03:56Z http://umpir.ump.edu.my/id/eprint/24003/ Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts Gnaneshwar, Puvala Vijayakumar Sudakaran, Shruthi Vathaluru Abisegapriyan, Sivasubramanian Sherine, Jositta Ramakrishna, Seeram Mohd Fadzil, Abdul Rahim M. M., Yusoff Rajan, Jose Venugopal, J. QD Chemistry QL Zoology RZ Other systems of medicine Far-flung evolution in tissue engineering enabled the development of bioactive and biodegradable materials to generate biocomposite nanofibrous scaffolds for bone repair and replacement therapies. Polymeric bioactive nanofibers are to biomimic the native extracellular matrix (ECM), delivering tremendous regenerative potentials for drug delivery and tissue engineering applications. It's been known from few decades that Zinc oxide (ZnO) nanoparticles are enhancing bone growth and providing proliferation of osteoblasts when incorporated with hydroxyapatite (HAp). We attempted to investigate the interaction between the human foetal osteoblasts (hFOB) with ZnO doped HAp incorporated biocomposite poly(L-lactic acid)-co-poly(ε-caprolactone) and silk fibroin (PLACL/SF) nanofibrous scaffolds for osteoblasts mineralization in bone tissue regeneration. The present study, we doped ZnO with HAp (ZnO(HAp) using the sol-gel ethanol condensation technique. The properties of PLACL/SF/ZnO(HAp) biocomposite nanofibrous scaffolds enhanced with doped and blended ZnO/HAp were characterized using Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Contact angle and Tensile studies to determine the morphology, functionality, wettability and stability. The in vitro study results showed that the addition of ZnO and HAp enhances the secretion of bone mineral matrix (98%) with smaller fiber diameter (139.4 ± 27 nm) due to the presence of silk fibroin showing potential tensile properties (322.4%), and increased the proliferation of osteoblasts for bone tissue regeneration. Elsevier Ltd 2019-03-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24003/1/Ramificationofzincoxidedopedhydroxyapatite1.pdf Gnaneshwar, Puvala Vijayakumar and Sudakaran, Shruthi Vathaluru and Abisegapriyan, Sivasubramanian and Sherine, Jositta and Ramakrishna, Seeram and Mohd Fadzil, Abdul Rahim and M. M., Yusoff and Rajan, Jose and Venugopal, J. (2019) Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts. Materials Science and Engineering: C, 96. pp. 337-346. ISSN 0928-4931 https://doi.org/10.1016/j.msec.2018.11.033 https://doi.org/10.1016/j.msec.2018.11.033
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry QL Zoology RZ Other systems of medicine
spellingShingle	QD Chemistry QL Zoology RZ Other systems of medicine Gnaneshwar, Puvala Vijayakumar Sudakaran, Shruthi Vathaluru Abisegapriyan, Sivasubramanian Sherine, Jositta Ramakrishna, Seeram Mohd Fadzil, Abdul Rahim M. M., Yusoff Rajan, Jose Venugopal, J. Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts
description	Far-flung evolution in tissue engineering enabled the development of bioactive and biodegradable materials to generate biocomposite nanofibrous scaffolds for bone repair and replacement therapies. Polymeric bioactive nanofibers are to biomimic the native extracellular matrix (ECM), delivering tremendous regenerative potentials for drug delivery and tissue engineering applications. It's been known from few decades that Zinc oxide (ZnO) nanoparticles are enhancing bone growth and providing proliferation of osteoblasts when incorporated with hydroxyapatite (HAp). We attempted to investigate the interaction between the human foetal osteoblasts (hFOB) with ZnO doped HAp incorporated biocomposite poly(L-lactic acid)-co-poly(ε-caprolactone) and silk fibroin (PLACL/SF) nanofibrous scaffolds for osteoblasts mineralization in bone tissue regeneration. The present study, we doped ZnO with HAp (ZnO(HAp) using the sol-gel ethanol condensation technique. The properties of PLACL/SF/ZnO(HAp) biocomposite nanofibrous scaffolds enhanced with doped and blended ZnO/HAp were characterized using Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Contact angle and Tensile studies to determine the morphology, functionality, wettability and stability. The in vitro study results showed that the addition of ZnO and HAp enhances the secretion of bone mineral matrix (98%) with smaller fiber diameter (139.4 ± 27 nm) due to the presence of silk fibroin showing potential tensile properties (322.4%), and increased the proliferation of osteoblasts for bone tissue regeneration.
format	Article
author	Gnaneshwar, Puvala Vijayakumar Sudakaran, Shruthi Vathaluru Abisegapriyan, Sivasubramanian Sherine, Jositta Ramakrishna, Seeram Mohd Fadzil, Abdul Rahim M. M., Yusoff Rajan, Jose Venugopal, J.
author_facet	Gnaneshwar, Puvala Vijayakumar Sudakaran, Shruthi Vathaluru Abisegapriyan, Sivasubramanian Sherine, Jositta Ramakrishna, Seeram Mohd Fadzil, Abdul Rahim M. M., Yusoff Rajan, Jose Venugopal, J.
author_sort	Gnaneshwar, Puvala Vijayakumar
title	Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts
title_short	Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts
title_full	Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts
title_fullStr	Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts
title_full_unstemmed	Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts
title_sort	ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts
publisher	Elsevier Ltd
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/24003/ http://umpir.ump.edu.my/id/eprint/24003/ http://umpir.ump.edu.my/id/eprint/24003/ http://umpir.ump.edu.my/id/eprint/24003/1/Ramificationofzincoxidedopedhydroxyapatite1.pdf
first_indexed	2023-09-18T22:36:09Z
last_indexed	2023-09-18T22:36:09Z
_version_	1777416609038598144

Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts

Similar Items