Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method

Ibuprofen is a Class II Biological Safety Class (BSC) drugs used for relief of arthritis, as an analgesic and possesses the effect of antiplatelet. The major problem involves in ibuprofen is it has a low solubility and high permeability thus causes an unsatisfactory therapeutic effect to humans. Thu...

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Main Authors: M. F., Othman, N., Anuar, Sunarti, Abd Rahman, N. A ., Ahmad Taifuddin
Format: Conference or Workshop Item
Language:English
English
Published: IOP Publishing 2017
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/23022/
http://umpir.ump.edu.my/id/eprint/23022/
http://umpir.ump.edu.my/id/eprint/23022/1/Cocrystal%20screening%20of%20ibuprofen%20with%20oxalic%20acid%20and%20citric%20acid%20via%20grinding%20method.pdf
http://umpir.ump.edu.my/id/eprint/23022/7/Cocrystal%20Screening%20of%20Ibuprofen%20with%20Oxalic%20Acid%20and%20Citric%20Acid%20via%20Grinding%20Method.pdf
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spelling ump-230222018-12-07T08:50:34Z http://umpir.ump.edu.my/id/eprint/23022/ Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method M. F., Othman N., Anuar Sunarti, Abd Rahman N. A ., Ahmad Taifuddin TP Chemical technology Ibuprofen is a Class II Biological Safety Class (BSC) drugs used for relief of arthritis, as an analgesic and possesses the effect of antiplatelet. The major problem involves in ibuprofen is it has a low solubility and high permeability thus causes an unsatisfactory therapeutic effect to humans. Thus, in this work, alteration of ibuprofen's physicochemical properties is conducted by means of cocrystallization technique. Co-crystallizations of ibuprofen were prepared with selected coformers using dry grinding and liquid assisted grinding (LAG) techniques in different molar ratios while ethanol and propanol were used as a solvent. The new crystalline forms were identified and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and fourier transform infrared spectroscopy (FTIR). Analysis for Ibuprofen-Citric acid (IBP-CA) system, co-crystal was successfully formed in 1:2, 1:3, 2:1 and 3:1 molar ratios for neat grinding method although the co-crystal produced is unstable. Meanwhile, for Ibuprofen-Oxalic acid (IBP-OA) system, the co-crystal formation was identified only in 1:1, 1:2 and 1:3 molar ratios for the neat grinding method. LAG method shows that co-crystal formation was unsuccessful in both solvents for IBP-CA, while IBP-OA co-crystal was formed in the molar ratio 1:1, 2:1 and 3:1 in ethanol, and 2:1 and 3:1 in propanol. IOP Publishing 2017 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23022/1/Cocrystal%20screening%20of%20ibuprofen%20with%20oxalic%20acid%20and%20citric%20acid%20via%20grinding%20method.pdf pdf en cc_by http://umpir.ump.edu.my/id/eprint/23022/7/Cocrystal%20Screening%20of%20Ibuprofen%20with%20Oxalic%20Acid%20and%20Citric%20Acid%20via%20Grinding%20Method.pdf M. F., Othman and N., Anuar and Sunarti, Abd Rahman and N. A ., Ahmad Taifuddin (2017) Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method. In: 3rd International Conference on Global Sustainability and Chemical Engineering, ICGSCE 2017, 15-16 February 2017 , Marriot Hotel, Putrajaya; Malaysia. pp. 1-6., 358 (1). ISSN 1757-8981 (Print), 1757-899X (Online) https://doi.org/10.1088/1757-899X/358/1/012065
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
English
topic TP Chemical technology
spellingShingle TP Chemical technology
M. F., Othman
N., Anuar
Sunarti, Abd Rahman
N. A ., Ahmad Taifuddin
Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method
description Ibuprofen is a Class II Biological Safety Class (BSC) drugs used for relief of arthritis, as an analgesic and possesses the effect of antiplatelet. The major problem involves in ibuprofen is it has a low solubility and high permeability thus causes an unsatisfactory therapeutic effect to humans. Thus, in this work, alteration of ibuprofen's physicochemical properties is conducted by means of cocrystallization technique. Co-crystallizations of ibuprofen were prepared with selected coformers using dry grinding and liquid assisted grinding (LAG) techniques in different molar ratios while ethanol and propanol were used as a solvent. The new crystalline forms were identified and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and fourier transform infrared spectroscopy (FTIR). Analysis for Ibuprofen-Citric acid (IBP-CA) system, co-crystal was successfully formed in 1:2, 1:3, 2:1 and 3:1 molar ratios for neat grinding method although the co-crystal produced is unstable. Meanwhile, for Ibuprofen-Oxalic acid (IBP-OA) system, the co-crystal formation was identified only in 1:1, 1:2 and 1:3 molar ratios for the neat grinding method. LAG method shows that co-crystal formation was unsuccessful in both solvents for IBP-CA, while IBP-OA co-crystal was formed in the molar ratio 1:1, 2:1 and 3:1 in ethanol, and 2:1 and 3:1 in propanol.
format Conference or Workshop Item
author M. F., Othman
N., Anuar
Sunarti, Abd Rahman
N. A ., Ahmad Taifuddin
author_facet M. F., Othman
N., Anuar
Sunarti, Abd Rahman
N. A ., Ahmad Taifuddin
author_sort M. F., Othman
title Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method
title_short Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method
title_full Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method
title_fullStr Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method
title_full_unstemmed Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method
title_sort cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method
publisher IOP Publishing
publishDate 2017
url http://umpir.ump.edu.my/id/eprint/23022/
http://umpir.ump.edu.my/id/eprint/23022/
http://umpir.ump.edu.my/id/eprint/23022/1/Cocrystal%20screening%20of%20ibuprofen%20with%20oxalic%20acid%20and%20citric%20acid%20via%20grinding%20method.pdf
http://umpir.ump.edu.my/id/eprint/23022/7/Cocrystal%20Screening%20of%20Ibuprofen%20with%20Oxalic%20Acid%20and%20Citric%20Acid%20via%20Grinding%20Method.pdf
first_indexed 2023-09-18T22:34:19Z
last_indexed 2023-09-18T22:34:19Z
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