Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals

Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, et...

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Main Authors:	Siti Kholijah, Abdul Mudalip, Mohd Rushdi, Abu Bakar, Jamal, Parveen, Fatmawati, Adam, Rohaida, Che Man, Siti Zubaidah, Sulaiman, Zatul Iffah, Mohd Arshad, Shalyda, Md Shaarani
Format:	Conference or Workshop Item
Language:	English
Published:	EDP Sciences 2018
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/21943/ http://umpir.ump.edu.my/id/eprint/21943/ http://umpir.ump.edu.my/id/eprint/21943/1/Abdul%20Mudalip%20et%20al%202018.pdf

id	ump-21943
recordtype	eprints
spelling	ump-219432018-08-14T08:23:15Z http://umpir.ump.edu.my/id/eprint/21943/ Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals Siti Kholijah, Abdul Mudalip Mohd Rushdi, Abu Bakar Jamal, Parveen Fatmawati, Adam Rohaida, Che Man Siti Zubaidah, Sulaiman Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani TP Chemical technology Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape. EDP Sciences 2018 Conference or Workshop Item PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/21943/1/Abdul%20Mudalip%20et%20al%202018.pdf Siti Kholijah, Abdul Mudalip and Mohd Rushdi, Abu Bakar and Jamal, Parveen and Fatmawati, Adam and Rohaida, Che Man and Siti Zubaidah, Sulaiman and Zatul Iffah, Mohd Arshad and Shalyda, Md Shaarani (2018) Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals. In: MATEC Web of Conferences: Malaysia Technical Universities Conference on Engineering and Technology (MUCET 2017), 6-7 December 2017 , Penang, Malaysia. pp. 1-6., 150 (02004). ISSN 2261-236X https://doi.org/10.1051/matecconf/201815002004
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Siti Kholijah, Abdul Mudalip Mohd Rushdi, Abu Bakar Jamal, Parveen Fatmawati, Adam Rohaida, Che Man Siti Zubaidah, Sulaiman Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals
description	Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape.
format	Conference or Workshop Item
author	Siti Kholijah, Abdul Mudalip Mohd Rushdi, Abu Bakar Jamal, Parveen Fatmawati, Adam Rohaida, Che Man Siti Zubaidah, Sulaiman Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani
author_facet	Siti Kholijah, Abdul Mudalip Mohd Rushdi, Abu Bakar Jamal, Parveen Fatmawati, Adam Rohaida, Che Man Siti Zubaidah, Sulaiman Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani
author_sort	Siti Kholijah, Abdul Mudalip
title	Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals
title_short	Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals
title_full	Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals
title_fullStr	Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals
title_full_unstemmed	Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals
title_sort	effects of solvents on polymorphism and shape of mefenamic acid crystals
publisher	EDP Sciences
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/21943/ http://umpir.ump.edu.my/id/eprint/21943/ http://umpir.ump.edu.my/id/eprint/21943/1/Abdul%20Mudalip%20et%20al%202018.pdf
first_indexed	2023-09-18T22:32:25Z
last_indexed	2023-09-18T22:32:25Z
_version_	1777416374396649472

Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals

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