A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli

Metabolic engineering is attentive about the alteration properties of metabolic pathways with the point of improving the generation of a few metabolics of intrigue. An essential range of metabolic engineering, the development is quite useful in the parameter identification/estimation of kinetic para...

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Main Authors:	Azrag, M. A. K., Tuty Asmawaty, Abdul Kadir, Mohd Arfian, Ismail
Format:	Article
Language:	English
Published:	American Scientific Publisher 2018
Subjects:	QA75 Electronic computers. Computer science TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/19954/ http://umpir.ump.edu.my/id/eprint/19954/ http://umpir.ump.edu.my/id/eprint/19954/ http://umpir.ump.edu.my/id/eprint/19954/1/A%20review%20of%20Large-%20Scale%20Kinetic%20Parameters.pdf

id	ump-19954
recordtype	eprints
spelling	ump-199542018-11-21T02:50:07Z http://umpir.ump.edu.my/id/eprint/19954/ A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli Azrag, M. A. K. Tuty Asmawaty, Abdul Kadir Mohd Arfian, Ismail QA75 Electronic computers. Computer science TP Chemical technology Metabolic engineering is attentive about the alteration properties of metabolic pathways with the point of improving the generation of a few metabolics of intrigue. An essential range of metabolic engineering, the development is quite useful in the parameter identification/estimation of kinetic parameters in the metabolic pathway. The development of metabolic kinetic model requires a detailed information of the initial concentration of enzymes, metabolites, co-metabolites, kinetic parameters and the cell condition. However, kinetic parameters play a significant role in building dynamic model. Kinetic parameters identification is usually used to reduce the errors in the simulation of the model or in the estimation of the model’s enzymes and metabolites. Moreover, the inverse problem, irreversible problem and the large scale attributes are the main issues to be considered for optimizing and estimating large scale kinetic parameters. This paper highlights the challenges inherent in the identification/estimation of kinetic parameters and the methods applied in solving the problems in the kinetic metabolic model of E. Coli following comprehensive analyses and discussions. American Scientific Publisher 2018-11 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19954/1/A%20review%20of%20Large-%20Scale%20Kinetic%20Parameters.pdf Azrag, M. A. K. and Tuty Asmawaty, Abdul Kadir and Mohd Arfian, Ismail (2018) A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli. Advanced Science Letters, 24 (10). pp. 7512-7518. ISSN 1936-6612 https://doi.org/10.1166/asl.2018.12969 doi: 10.1166/asl.2018.12969
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QA75 Electronic computers. Computer science TP Chemical technology
spellingShingle	QA75 Electronic computers. Computer science TP Chemical technology Azrag, M. A. K. Tuty Asmawaty, Abdul Kadir Mohd Arfian, Ismail A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli
description	Metabolic engineering is attentive about the alteration properties of metabolic pathways with the point of improving the generation of a few metabolics of intrigue. An essential range of metabolic engineering, the development is quite useful in the parameter identification/estimation of kinetic parameters in the metabolic pathway. The development of metabolic kinetic model requires a detailed information of the initial concentration of enzymes, metabolites, co-metabolites, kinetic parameters and the cell condition. However, kinetic parameters play a significant role in building dynamic model. Kinetic parameters identification is usually used to reduce the errors in the simulation of the model or in the estimation of the model’s enzymes and metabolites. Moreover, the inverse problem, irreversible problem and the large scale attributes are the main issues to be considered for optimizing and estimating large scale kinetic parameters. This paper highlights the challenges inherent in the identification/estimation of kinetic parameters and the methods applied in solving the problems in the kinetic metabolic model of E. Coli following comprehensive analyses and discussions.
format	Article
author	Azrag, M. A. K. Tuty Asmawaty, Abdul Kadir Mohd Arfian, Ismail
author_facet	Azrag, M. A. K. Tuty Asmawaty, Abdul Kadir Mohd Arfian, Ismail
author_sort	Azrag, M. A. K.
title	A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli
title_short	A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli
title_full	A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli
title_fullStr	A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli
title_full_unstemmed	A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli
title_sort	review of large-scale kinetic parameters in metabolic network model of escherichia coli
publisher	American Scientific Publisher
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/19954/ http://umpir.ump.edu.my/id/eprint/19954/ http://umpir.ump.edu.my/id/eprint/19954/ http://umpir.ump.edu.my/id/eprint/19954/1/A%20review%20of%20Large-%20Scale%20Kinetic%20Parameters.pdf
first_indexed	2023-09-18T22:28:36Z
last_indexed	2023-09-18T22:28:36Z
_version_	1777416133990678528

A Review of Large-Scale Kinetic Parameters in Metabolic Network Model of Escherichia coli

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