Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities

Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nont...

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Main Authors:	Ghawanmeh, Abdullah A., K. F., Chong, Sarkar, Shaheen M., Muntaz, Abu Bakar, Rizafizah, Othaman, Rozida, M. Khalid
Format:	Article
Language:	English
Published:	Elsevier 2018
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/8/fist-2017-kwok-Colchicine%20prodrugs%20and%20codrugs1.pdf

id	ump-19831
recordtype	eprints
spelling	ump-198312018-10-25T01:08:26Z http://umpir.ump.edu.my/id/eprint/19831/ Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid QD Chemistry Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nontoxic biofunctional compounds modified further affords a new entity in chemical structure with enhanced activity and selectivity. Moreover, nanocarrier formulation strategies have been used for colchicine delivery. This review paper focuses on colchicine nanoformulation, chemical synthesis of colchicine prodrugs and codrugs with different linkers, highlights linker chemical nature and biological activity of synthesized compounds. Additionally, classification of colchicine prodrugs based on type of conjugates is discussed, as biopolymers prodrugs,fluorescent prodrug, metal complexes prodrug, metal-labile prodrug and bioconjugate prodrug. Finally, we briefly summarized the biological importance of colchicine nanoformulation, colchicine prodrugs and codrugs. © Elsevier 2018-12-08 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/19831/8/fist-2017-kwok-Colchicine%20prodrugs%20and%20codrugs1.pdf Ghawanmeh, Abdullah A. and K. F., Chong and Sarkar, Shaheen M. and Muntaz, Abu Bakar and Rizafizah, Othaman and Rozida, M. Khalid (2018) Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities. European Journal of Medicinal Chemistry, 144. pp. 229-242. ISSN 0223-5234 https://doi.org/10.1016/j.ejmech.2017.12.029 doi: 10.1016/j.ejmech.2017.12.029
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
description	Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nontoxic biofunctional compounds modified further affords a new entity in chemical structure with enhanced activity and selectivity. Moreover, nanocarrier formulation strategies have been used for colchicine delivery. This review paper focuses on colchicine nanoformulation, chemical synthesis of colchicine prodrugs and codrugs with different linkers, highlights linker chemical nature and biological activity of synthesized compounds. Additionally, classification of colchicine prodrugs based on type of conjugates is discussed, as biopolymers prodrugs,fluorescent prodrug, metal complexes prodrug, metal-labile prodrug and bioconjugate prodrug. Finally, we briefly summarized the biological importance of colchicine nanoformulation, colchicine prodrugs and codrugs. ©
format	Article
author	Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid
author_facet	Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid
author_sort	Ghawanmeh, Abdullah A.
title	Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
title_short	Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
title_full	Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
title_fullStr	Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
title_full_unstemmed	Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
title_sort	colchicine prodrugs and codrugs: chemistry and bioactivities
publisher	Elsevier
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/8/fist-2017-kwok-Colchicine%20prodrugs%20and%20codrugs1.pdf
first_indexed	2023-09-18T22:28:26Z
last_indexed	2023-09-18T22:28:26Z
_version_	1777416123218657280

Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities

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