Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nont...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/8/fist-2017-kwok-Colchicine%20prodrugs%20and%20codrugs1.pdf |
| Summary: | Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell.
However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and
structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nontoxic
biofunctional compounds modified further affords a new entity in chemical structure with enhanced
activity and selectivity. Moreover, nanocarrier formulation strategies have been used for colchicine delivery. This review paper focuses on colchicine nanoformulation, chemical synthesis of colchicine prodrugs and codrugs with different linkers, highlights linker chemical nature and biological activity of
synthesized compounds. Additionally, classification of colchicine prodrugs based on type of conjugates is
discussed, as biopolymers prodrugs,fluorescent prodrug, metal complexes prodrug, metal-labile prodrug
and bioconjugate prodrug. Finally, we briefly summarized the biological importance of colchicine
nanoformulation, colchicine prodrugs and codrugs.
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