Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity

Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity

6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 ± 0.20 μM) an...

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Main Authors: Taha, Muhammad, Sultan, Sadia, Mohamad, Azlan, Syed Adnan, Ali Shah, Jamil, Waqas, Swee, KeongYeap, Syahrul, Imran, Akhtar, Muhammad Nadeem, Seema, Zareen, Nor Hadiani, Ismail, Ali, Muhammad
Format: Article
Language:English
Published: Elsevier 2017
Subjects:
Q Science (General)
Online Access:http://umpir.ump.edu.my/id/eprint/19769/
http://umpir.ump.edu.my/id/eprint/19769/
http://umpir.ump.edu.my/id/eprint/19769/
http://umpir.ump.edu.my/id/eprint/19769/1/fist-2017-nadeem-Synthesis%20of%20a%20series%20of%20new%206-nitrobenzofuran-2-carbohydrazide1.pdf
id ump-19769
recordtype eprints
spelling ump-197692018-04-05T06:16:02Z http://umpir.ump.edu.my/id/eprint/19769/ Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity Taha, Muhammad Sultan, Sadia Mohamad, Azlan Syed Adnan, Ali Shah Jamil, Waqas Swee, KeongYeap Syahrul, Imran Akhtar, Muhammad Nadeem Seema, Zareen Nor Hadiani, Ismail Ali, Muhammad Q Science (General) 6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 ± 0.20 μM) and n-propyl gallate (IC50 = 30.30 ± 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 ± 0.90 μM), 2 (IC50 = 2.70 ± 0.25 μM), 3 (IC50 = 2.70 ± 0.25 μM), 10 (IC50 = 2.70 ± 1.10 μM), 11 (IC50 = 1.00 ± 1.20 μM), and 17 (IC50 = 3.75 ± 0.90 μM) showed excellent while 21 (IC50 = 7.50 ± 0.60 μM) and 28 (IC50 = 7.50 ± 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 ± 0.85 μM), 11 (IC50 = 24.20 ± 0.55 μM), 12 (IC50 = 21.10 ± 1.58 μM), 13 (IC50 = 14.60 ± 0.32 μM), 14 (IC50 = 29.20 ± 0.75 μM) and 15 (IC50 = 9.26 ± 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential. Elsevier 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19769/1/fist-2017-nadeem-Synthesis%20of%20a%20series%20of%20new%206-nitrobenzofuran-2-carbohydrazide1.pdf Taha, Muhammad and Sultan, Sadia and Mohamad, Azlan and Syed Adnan, Ali Shah and Jamil, Waqas and Swee, KeongYeap and Syahrul, Imran and Akhtar, Muhammad Nadeem and Seema, Zareen and Nor Hadiani, Ismail and Ali, Muhammad (2017) Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity. New Horizons in Translational Medicine, 4 (1-4). pp. 23-30. ISSN 2307-5023 https://doi.org/10.1016/j.nhtm.2017.08.002 doi: 10.1016/j.nhtm.2017.08.002
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic Q Science (General)
spellingShingle Q Science (General)
Taha, Muhammad
Sultan, Sadia
Mohamad, Azlan
Syed Adnan, Ali Shah
Jamil, Waqas
Swee, KeongYeap
Syahrul, Imran
Akhtar, Muhammad Nadeem
Seema, Zareen
Nor Hadiani, Ismail
Ali, Muhammad
Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity
description 6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 ± 0.20 μM) and n-propyl gallate (IC50 = 30.30 ± 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 ± 0.90 μM), 2 (IC50 = 2.70 ± 0.25 μM), 3 (IC50 = 2.70 ± 0.25 μM), 10 (IC50 = 2.70 ± 1.10 μM), 11 (IC50 = 1.00 ± 1.20 μM), and 17 (IC50 = 3.75 ± 0.90 μM) showed excellent while 21 (IC50 = 7.50 ± 0.60 μM) and 28 (IC50 = 7.50 ± 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 ± 0.85 μM), 11 (IC50 = 24.20 ± 0.55 μM), 12 (IC50 = 21.10 ± 1.58 μM), 13 (IC50 = 14.60 ± 0.32 μM), 14 (IC50 = 29.20 ± 0.75 μM) and 15 (IC50 = 9.26 ± 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.
format Article
author Taha, Muhammad
Sultan, Sadia
Mohamad, Azlan
Syed Adnan, Ali Shah
Jamil, Waqas
Swee, KeongYeap
Syahrul, Imran
Akhtar, Muhammad Nadeem
Seema, Zareen
Nor Hadiani, Ismail
Ali, Muhammad
author_facet Taha, Muhammad
Sultan, Sadia
Mohamad, Azlan
Syed Adnan, Ali Shah
Jamil, Waqas
Swee, KeongYeap
Syahrul, Imran
Akhtar, Muhammad Nadeem
Seema, Zareen
Nor Hadiani, Ismail
Ali, Muhammad
author_sort Taha, Muhammad
title Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity
title_short Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity
title_full Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity
title_fullStr Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity
title_full_unstemmed Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity
title_sort synthesis of a series of new 6-nitrobenzofuran-2-carbohydrazide derivatives with cytotoxic and antioxidant activity
publisher Elsevier
publishDate 2017
url http://umpir.ump.edu.my/id/eprint/19769/
http://umpir.ump.edu.my/id/eprint/19769/
http://umpir.ump.edu.my/id/eprint/19769/
http://umpir.ump.edu.my/id/eprint/19769/1/fist-2017-nadeem-Synthesis%20of%20a%20series%20of%20new%206-nitrobenzofuran-2-carbohydrazide1.pdf
first_indexed 2023-09-18T22:28:20Z
last_indexed 2023-09-18T22:28:20Z
_version_ 1777416117645475840

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