The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond

The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond

Background: Vitamin D, a molecular precursor of the potent steroid hormone calcitriol, has crucial functions and roles in physiology and pathophysiology. Tellingly, calcitriol has been shown to regulate various cellular signalling networks and cascades that have crucial role in cancer biology and di...

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Main Authors: Almatar, Manaf, AlMandeal, Husam, Makky, Essam A., Kayar, Begum, Yarar, Emel, Var, Isıl, Koksal, Fatih
Format: Article
Language:English
Published: Bentham Science Publishers 2017
Subjects:
Q Science (General)
QR Microbiology
Online Access:http://umpir.ump.edu.my/id/eprint/19676/
http://umpir.ump.edu.my/id/eprint/19676/
http://umpir.ump.edu.my/id/eprint/19676/
http://umpir.ump.edu.my/id/eprint/19676/7/physiological-essam-fist-2017.pdf
id ump-19676
recordtype eprints
spelling ump-196762018-09-27T08:41:13Z http://umpir.ump.edu.my/id/eprint/19676/ The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond Almatar, Manaf AlMandeal, Husam Makky, Essam A. Kayar, Begum Yarar, Emel Var, Isıl Koksal, Fatih Q Science (General) QR Microbiology Background: Vitamin D, a molecular precursor of the potent steroid hormone calcitriol, has crucial functions and roles in physiology and pathophysiology. Tellingly, calcitriol has been shown to regulate various cellular signalling networks and cascades that have crucial role in cancer biology and diagnostics. Mounting lines of evidences from previous clinical and preclinical investigations indicate that the deficiency of vitamin D may contribute to the carcinogenesis risk. Concomitantly, recent reports suggested that significant reduction in the cancer occurrence and progression is more likely to appear after vitamin D supplementation. Furthermore, a pivotal role functioned by vitamin D in cardiovascular physiology indicates that the deficiency of vitamin D is significantly correlated with enhanced prevalence of stroke, hypertension and myocardial infarction. Notably, vitamin D status is more likely to be used as a lifestyle biomarker, since poor and unhealthy lifestyles are correlated with the deficiency of vitamin D, a feature which may result in cardiovascular complications. Moreover, recent reports revealed that the effect of vitamin D is to cover not only cardiovascular system but also skeletal system. Bentham Science Publishers 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19676/7/physiological-essam-fist-2017.pdf Almatar, Manaf and AlMandeal, Husam and Makky, Essam A. and Kayar, Begum and Yarar, Emel and Var, Isıl and Koksal, Fatih (2017) The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond. Current Drug Metabolism, 18 (3). pp. 207-224. ISSN 1875-5453 https://doi.org/10.2174/1389200217666161207161212 doi: 10.2174/1389200217666161207161212
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic Q Science (General)
QR Microbiology
spellingShingle Q Science (General)
QR Microbiology
Almatar, Manaf
AlMandeal, Husam
Makky, Essam A.
Kayar, Begum
Yarar, Emel
Var, Isıl
Koksal, Fatih
The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond
description Background: Vitamin D, a molecular precursor of the potent steroid hormone calcitriol, has crucial functions and roles in physiology and pathophysiology. Tellingly, calcitriol has been shown to regulate various cellular signalling networks and cascades that have crucial role in cancer biology and diagnostics. Mounting lines of evidences from previous clinical and preclinical investigations indicate that the deficiency of vitamin D may contribute to the carcinogenesis risk. Concomitantly, recent reports suggested that significant reduction in the cancer occurrence and progression is more likely to appear after vitamin D supplementation. Furthermore, a pivotal role functioned by vitamin D in cardiovascular physiology indicates that the deficiency of vitamin D is significantly correlated with enhanced prevalence of stroke, hypertension and myocardial infarction. Notably, vitamin D status is more likely to be used as a lifestyle biomarker, since poor and unhealthy lifestyles are correlated with the deficiency of vitamin D, a feature which may result in cardiovascular complications. Moreover, recent reports revealed that the effect of vitamin D is to cover not only cardiovascular system but also skeletal system.
format Article
author Almatar, Manaf
AlMandeal, Husam
Makky, Essam A.
Kayar, Begum
Yarar, Emel
Var, Isıl
Koksal, Fatih
author_facet Almatar, Manaf
AlMandeal, Husam
Makky, Essam A.
Kayar, Begum
Yarar, Emel
Var, Isıl
Koksal, Fatih
author_sort Almatar, Manaf
title The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond
title_short The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond
title_full The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond
title_fullStr The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond
title_full_unstemmed The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond
title_sort physiological/pathophysiological significance of vitamin d in cancer, cardiovascular disorders and beyond
publisher Bentham Science Publishers
publishDate 2017
url http://umpir.ump.edu.my/id/eprint/19676/
http://umpir.ump.edu.my/id/eprint/19676/
http://umpir.ump.edu.my/id/eprint/19676/
http://umpir.ump.edu.my/id/eprint/19676/7/physiological-essam-fist-2017.pdf
first_indexed 2023-09-18T22:28:10Z
last_indexed 2023-09-18T22:28:10Z
_version_ 1777416106512744448

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