Novel Compounds Targeting InhA for TB Therapy

Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the treatment of TB. Therefore, new agents to replace existing drugs are urgently needed. Previous reports suggested that InhA inhibitors, an enoyl-ACP-reductase,...

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Main Authors:	Almatar, Manaf, Makky, Essam A., Var, Isıl, Kayar, Begum, Koksal, Fatih
Format:	Article
Language:	English
Published:	Elsevier 2018
Subjects:	Q Science (General) QR Microbiology
Online Access:	http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/1/Novel%20compounds%20targeting%20InhA%20for%20TB%20therapy-fist-2018.pdf

id	ump-19673
recordtype	eprints
spelling	ump-196732018-06-12T02:13:54Z http://umpir.ump.edu.my/id/eprint/19673/ Novel Compounds Targeting InhA for TB Therapy Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih Q Science (General) QR Microbiology Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the treatment of TB. Therefore, new agents to replace existing drugs are urgently needed. Previous reports suggested that InhA inhibitors, an enoyl-ACP-reductase, might provide auspicious candidates which can be developed into novel antitubercular agents. In this review, we explain the role of InhA in the resistance of isoniazid. Furthermore, five classes of InhA inhibitors, which display novel binding modes and deliver evidence of their prosperous target engagement, have been debated. Elsevier 2018 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19673/1/Novel%20compounds%20targeting%20InhA%20for%20TB%20therapy-fist-2018.pdf Almatar, Manaf and Makky, Essam A. and Var, Isıl and Kayar, Begum and Koksal, Fatih (2018) Novel Compounds Targeting InhA for TB Therapy. Pharmacological Reports, 70 (2). pp. 217-226. ISSN 1734-1140 https://doi.org/10.1016/j.pharep.2017.09.001 doi: 10.1016/j.pharep.2017.09.001
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General) QR Microbiology
spellingShingle	Q Science (General) QR Microbiology Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih Novel Compounds Targeting InhA for TB Therapy
description	Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the treatment of TB. Therefore, new agents to replace existing drugs are urgently needed. Previous reports suggested that InhA inhibitors, an enoyl-ACP-reductase, might provide auspicious candidates which can be developed into novel antitubercular agents. In this review, we explain the role of InhA in the resistance of isoniazid. Furthermore, five classes of InhA inhibitors, which display novel binding modes and deliver evidence of their prosperous target engagement, have been debated.
format	Article
author	Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih
author_facet	Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih
author_sort	Almatar, Manaf
title	Novel Compounds Targeting InhA for TB Therapy
title_short	Novel Compounds Targeting InhA for TB Therapy
title_full	Novel Compounds Targeting InhA for TB Therapy
title_fullStr	Novel Compounds Targeting InhA for TB Therapy
title_full_unstemmed	Novel Compounds Targeting InhA for TB Therapy
title_sort	novel compounds targeting inha for tb therapy
publisher	Elsevier
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/1/Novel%20compounds%20targeting%20InhA%20for%20TB%20therapy-fist-2018.pdf
first_indexed	2023-09-18T22:28:10Z
last_indexed	2023-09-18T22:28:10Z
_version_	1777416106223337472

Novel Compounds Targeting InhA for TB Therapy

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