Solubility of Carbamazepine Co-Crystals in Ethanolic Solution
The study aimed to determine the solubility of carbamazepine (CBZ) co-crystals formed from co-crystal formers (CCFs) of nicotinamide (NIC), saccharin (SAC), succinic acid (SUC) and fumaric acid (FUM) at various temperatures (25-50°C). High Performance Liquid Chromatography (HPLC) was used to deter...
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| Format: | Conference or Workshop Item |
| Language: | English |
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AIP Publishing
2017
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| Online Access: | http://umpir.ump.edu.my/id/eprint/18693/ http://umpir.ump.edu.my/id/eprint/18693/ http://umpir.ump.edu.my/id/eprint/18693/1/fkksa-2017-ashila-Solubility%20of%20Carbamazepine%20Co.pdf |
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ump-18693 |
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ump-186932017-11-03T01:13:40Z http://umpir.ump.edu.my/id/eprint/18693/ Solubility of Carbamazepine Co-Crystals in Ethanolic Solution Noor Ashila, Ramle Syarifah, Abd Rahim Nornizar, Anuar El-Hadad, Omar TP Chemical technology The study aimed to determine the solubility of carbamazepine (CBZ) co-crystals formed from co-crystal formers (CCFs) of nicotinamide (NIC), saccharin (SAC), succinic acid (SUC) and fumaric acid (FUM) at various temperatures (25-50°C). High Performance Liquid Chromatography (HPLC) was used to determine the solubility and the X-Ray Powder Diffraction was used to characterize the crystals. The solubility of CBZ-NIC and CBZ-FUM co-crystals were found to be higher than the solubility of the CBZ for the range of studied temperatures. However, opposite findings was obtained for CBZ-SUC co-crystal as its solubility is lower than the solubility of CBZ. Different trend was found for CBZ-SAC co-crystal in which for temperature lower than 40°C, the solubility of CBZ crystal is higher than the CBZSAC co-crystal. The solubility of CBZ-SAC co-crystal is higher than the solubility of CBZ at a temperature above 40°C. CBZ co-crystals with NIC and FUM have shown to increase the solubility of CBZ by solubility ratio of 1.95 and 1.24 respectively. However, the CBZ co-crystal with SAC was found to have similar solubility value as the CBZ. AIP Publishing 2017 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/18693/1/fkksa-2017-ashila-Solubility%20of%20Carbamazepine%20Co.pdf Noor Ashila, Ramle and Syarifah, Abd Rahim and Nornizar, Anuar and El-Hadad, Omar (2017) Solubility of Carbamazepine Co-Crystals in Ethanolic Solution. In: AIP Conference Proceedings: 3rd International Conference On Chemical Materials And Process (ICCMP 2017), 25-27 May 2017 , Beijing, China. pp. 1-7., 1879 (040001). ISBN 978-0-7354-1559-1 http://dx.doi.org/10.1063/1.5000468 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
Universiti Malaysia Pahang |
| building |
UMP Institutional Repository |
| collection |
Online Access |
| language |
English |
| topic |
TP Chemical technology |
| spellingShingle |
TP Chemical technology Noor Ashila, Ramle Syarifah, Abd Rahim Nornizar, Anuar El-Hadad, Omar Solubility of Carbamazepine Co-Crystals in Ethanolic Solution |
| description |
The study aimed to determine the solubility of carbamazepine (CBZ) co-crystals formed from co-crystal
formers (CCFs) of nicotinamide (NIC), saccharin (SAC), succinic acid (SUC) and fumaric acid (FUM) at various
temperatures (25-50°C). High Performance Liquid Chromatography (HPLC) was used to determine the solubility and the
X-Ray Powder Diffraction was used to characterize the crystals. The solubility of CBZ-NIC and CBZ-FUM co-crystals
were found to be higher than the solubility of the CBZ for the range of studied temperatures. However, opposite findings
was obtained for CBZ-SUC co-crystal as its solubility is lower than the solubility of CBZ. Different trend was found for CBZ-SAC co-crystal in which for temperature lower than 40°C, the solubility of CBZ crystal is higher than the CBZSAC
co-crystal. The solubility of CBZ-SAC co-crystal is higher than the solubility of CBZ at a temperature above 40°C.
CBZ co-crystals with NIC and FUM have shown to increase the solubility of CBZ by solubility ratio of 1.95 and 1.24
respectively. However, the CBZ co-crystal with SAC was found to have similar solubility value as the CBZ. |
| format |
Conference or Workshop Item |
| author |
Noor Ashila, Ramle Syarifah, Abd Rahim Nornizar, Anuar El-Hadad, Omar |
| author_facet |
Noor Ashila, Ramle Syarifah, Abd Rahim Nornizar, Anuar El-Hadad, Omar |
| author_sort |
Noor Ashila, Ramle |
| title |
Solubility of Carbamazepine Co-Crystals in Ethanolic
Solution |
| title_short |
Solubility of Carbamazepine Co-Crystals in Ethanolic
Solution |
| title_full |
Solubility of Carbamazepine Co-Crystals in Ethanolic
Solution |
| title_fullStr |
Solubility of Carbamazepine Co-Crystals in Ethanolic
Solution |
| title_full_unstemmed |
Solubility of Carbamazepine Co-Crystals in Ethanolic
Solution |
| title_sort |
solubility of carbamazepine co-crystals in ethanolic
solution |
| publisher |
AIP Publishing |
| publishDate |
2017 |
| url |
http://umpir.ump.edu.my/id/eprint/18693/ http://umpir.ump.edu.my/id/eprint/18693/ http://umpir.ump.edu.my/id/eprint/18693/1/fkksa-2017-ashila-Solubility%20of%20Carbamazepine%20Co.pdf |
| first_indexed |
2023-09-18T22:26:38Z |
| last_indexed |
2023-09-18T22:26:38Z |
| _version_ |
1777416009986080768 |