Solubility of Carbamazepine Co-Crystals in Ethanolic Solution
The study aimed to determine the solubility of carbamazepine (CBZ) co-crystals formed from co-crystal formers (CCFs) of nicotinamide (NIC), saccharin (SAC), succinic acid (SUC) and fumaric acid (FUM) at various temperatures (25-50°C). High Performance Liquid Chromatography (HPLC) was used to deter...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
AIP Publishing
2017
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/18693/ http://umpir.ump.edu.my/id/eprint/18693/ http://umpir.ump.edu.my/id/eprint/18693/1/fkksa-2017-ashila-Solubility%20of%20Carbamazepine%20Co.pdf |
| Summary: | The study aimed to determine the solubility of carbamazepine (CBZ) co-crystals formed from co-crystal
formers (CCFs) of nicotinamide (NIC), saccharin (SAC), succinic acid (SUC) and fumaric acid (FUM) at various
temperatures (25-50°C). High Performance Liquid Chromatography (HPLC) was used to determine the solubility and the
X-Ray Powder Diffraction was used to characterize the crystals. The solubility of CBZ-NIC and CBZ-FUM co-crystals
were found to be higher than the solubility of the CBZ for the range of studied temperatures. However, opposite findings
was obtained for CBZ-SUC co-crystal as its solubility is lower than the solubility of CBZ. Different trend was found for CBZ-SAC co-crystal in which for temperature lower than 40°C, the solubility of CBZ crystal is higher than the CBZSAC
co-crystal. The solubility of CBZ-SAC co-crystal is higher than the solubility of CBZ at a temperature above 40°C.
CBZ co-crystals with NIC and FUM have shown to increase the solubility of CBZ by solubility ratio of 1.95 and 1.24
respectively. However, the CBZ co-crystal with SAC was found to have similar solubility value as the CBZ. |
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