Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia

Medicinal and aromatic plants (MAPs) are widely valued for their aromas, tastes, and treatments for various human illnesses. The chemical constituents and toxicity content of three aromatic plant species, Syzygium polyanthum Wight (Walp.), Monocarpia marginalis (Scheff.) J. Sinclair, and Chromolaena...

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Main Authors:	Siti Rahimah, Jumaat, Saiful Nizam, Tajuddin, Runglawan, Sudmoon, Arunrat, Chaveerach, Ummi Hani, Abdullah, Rozi, Mohamed
Format:	Article
Language:	English
Published:	North Carolina State University 2017
Subjects:	Q Science (General) TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/18137/ http://umpir.ump.edu.my/id/eprint/18137/ http://umpir.ump.edu.my/id/eprint/18137/1/Chemical%20Constituents%20and%20Toxicity%20Screening%20of%20Three%20Aromatic%20Plant%20Species%20from%20Peninsular%20Malaysia.pdf

id	ump-18137
recordtype	eprints
spelling	ump-181372018-01-17T07:06:02Z http://umpir.ump.edu.my/id/eprint/18137/ Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia Siti Rahimah, Jumaat Saiful Nizam, Tajuddin Runglawan, Sudmoon Arunrat, Chaveerach Ummi Hani, Abdullah Rozi, Mohamed Q Science (General) TP Chemical technology Medicinal and aromatic plants (MAPs) are widely valued for their aromas, tastes, and treatments for various human illnesses. The chemical constituents and toxicity content of three aromatic plant species, Syzygium polyanthum Wight (Walp.), Monocarpia marginalis (Scheff.) J. Sinclair, and Chromolaena odorata (L.) R.M. King & H. Rob, were determined, via gas chromatography (GC) with mass spectrometry (MS), and flame ionization detector (FID). Altogether, 116 compounds were identified in the essential oils and hexane and methanol extracts. Toxicity evaluations were carried out on human peripheral blood mononuclear cells (PBMCs). Three plant samples were found toxic to human PBMCs. The essential oils of M. marginalis and C. odorata, and the hexane extract of C. odorata yielded IC50 and LD50 values of 76 mg/mL and 6,913 mg/kg, 14 mg/mL and 3,684 mg/kg, and 2.45 mg/mL and 1,927 mg/kg, respectively. Based on the LD50 values, M. marginalis and C. odorata can be classified as slightly and moderately hazardous, respectively. A detailed toxicity evaluation via comet assay showed that M. marginalis and C. odorata induced significant DNA damage (p < 0.05). As for S. polyanthum, the species did not give any cytotoxic or genotoxic evidences. North Carolina State University 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/18137/1/Chemical%20Constituents%20and%20Toxicity%20Screening%20of%20Three%20Aromatic%20Plant%20Species%20from%20Peninsular%20Malaysia.pdf Siti Rahimah, Jumaat and Saiful Nizam, Tajuddin and Runglawan, Sudmoon and Arunrat, Chaveerach and Ummi Hani, Abdullah and Rozi, Mohamed (2017) Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia. BioResources, 12 (3). pp. 5878-5896. ISSN 1930-2126 (print); 1930-2126 (online) http://152.1.0.246/index.php/BioRes/article/view/BioRes_12_3_5878_Jumaat_Chemical_Constituents_Toxicity_Screening
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General) TP Chemical technology
spellingShingle	Q Science (General) TP Chemical technology Siti Rahimah, Jumaat Saiful Nizam, Tajuddin Runglawan, Sudmoon Arunrat, Chaveerach Ummi Hani, Abdullah Rozi, Mohamed Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia
description	Medicinal and aromatic plants (MAPs) are widely valued for their aromas, tastes, and treatments for various human illnesses. The chemical constituents and toxicity content of three aromatic plant species, Syzygium polyanthum Wight (Walp.), Monocarpia marginalis (Scheff.) J. Sinclair, and Chromolaena odorata (L.) R.M. King & H. Rob, were determined, via gas chromatography (GC) with mass spectrometry (MS), and flame ionization detector (FID). Altogether, 116 compounds were identified in the essential oils and hexane and methanol extracts. Toxicity evaluations were carried out on human peripheral blood mononuclear cells (PBMCs). Three plant samples were found toxic to human PBMCs. The essential oils of M. marginalis and C. odorata, and the hexane extract of C. odorata yielded IC50 and LD50 values of 76 mg/mL and 6,913 mg/kg, 14 mg/mL and 3,684 mg/kg, and 2.45 mg/mL and 1,927 mg/kg, respectively. Based on the LD50 values, M. marginalis and C. odorata can be classified as slightly and moderately hazardous, respectively. A detailed toxicity evaluation via comet assay showed that M. marginalis and C. odorata induced significant DNA damage (p < 0.05). As for S. polyanthum, the species did not give any cytotoxic or genotoxic evidences.
format	Article
author	Siti Rahimah, Jumaat Saiful Nizam, Tajuddin Runglawan, Sudmoon Arunrat, Chaveerach Ummi Hani, Abdullah Rozi, Mohamed
author_facet	Siti Rahimah, Jumaat Saiful Nizam, Tajuddin Runglawan, Sudmoon Arunrat, Chaveerach Ummi Hani, Abdullah Rozi, Mohamed
author_sort	Siti Rahimah, Jumaat
title	Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia
title_short	Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia
title_full	Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia
title_fullStr	Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia
title_full_unstemmed	Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia
title_sort	chemical constituents and toxicity screening of three aromatic plant species from peninsular malaysia
publisher	North Carolina State University
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/18137/ http://umpir.ump.edu.my/id/eprint/18137/ http://umpir.ump.edu.my/id/eprint/18137/1/Chemical%20Constituents%20and%20Toxicity%20Screening%20of%20Three%20Aromatic%20Plant%20Species%20from%20Peninsular%20Malaysia.pdf
first_indexed	2023-09-18T22:25:30Z
last_indexed	2023-09-18T22:25:30Z
_version_	1777415938944008192

Chemical Constituents and Toxicity Screening of Three Aromatic Plant Species from Peninsular Malaysia

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