Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal

Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods...

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Main Authors:	Engku Nadia, Engku Mat Nasir, Fatinah, Ab Rahman, Syarifah, Abd Rahim, Raihana Z., Edros, Nornizar, Anuar
Format:	Article
Language:	English
Published:	Informatics Publishing Limited 2017
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/17467/ http://umpir.ump.edu.my/id/eprint/17467/ http://umpir.ump.edu.my/id/eprint/17467/ http://umpir.ump.edu.my/id/eprint/17467/1/fkksa-2017-syarifah-Preliminary%20Study%20on%20Operating%20Parameters.pdf

id	ump-17467
recordtype	eprints
spelling	ump-174672019-10-30T07:38:24Z http://umpir.ump.edu.my/id/eprint/17467/ Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar TP Chemical technology Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs. Informatics Publishing Limited 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/17467/1/fkksa-2017-syarifah-Preliminary%20Study%20on%20Operating%20Parameters.pdf Engku Nadia, Engku Mat Nasir and Fatinah, Ab Rahman and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2017) Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal. Indian Journal of Science and Technology, 10 (7). pp. 1-5. ISSN 0974-6846 (Print); 0974-5645 (Online) http://www.indjst.org/index.php/indjst/article/view/111216 DOI: 10.17485/ijst/2017/v10i7/111216
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
description	Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs.
format	Article
author	Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar
author_facet	Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar
author_sort	Engku Nadia, Engku Mat Nasir
title	Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
title_short	Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
title_full	Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
title_fullStr	Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
title_full_unstemmed	Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
title_sort	preliminary study on operating parameters toward the metastable zone-width of carbamazepine co-crystal
publisher	Informatics Publishing Limited
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/17467/ http://umpir.ump.edu.my/id/eprint/17467/ http://umpir.ump.edu.my/id/eprint/17467/ http://umpir.ump.edu.my/id/eprint/17467/1/fkksa-2017-syarifah-Preliminary%20Study%20on%20Operating%20Parameters.pdf
first_indexed	2023-09-18T22:24:08Z
last_indexed	2023-09-18T22:24:08Z
_version_	1777415852717506560

Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal

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