Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal

Objectives: In pharmaceutical industries, the properties of desired final crystal can be modified by seeding process. Seeding activities depend on seed loading, seed size, seed quality and the temperature of supersaturated solution at the time of seed addition. The effect of amount of seed and tempe...

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Main Authors:	K. A., Mohammad, Syarifah, Abd Rahim, M. R., Abu Bakar
Format:	Article
Language:	English
Published:	Informatics Publishing Limited 2017
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/17382/ http://umpir.ump.edu.my/id/eprint/17382/ http://umpir.ump.edu.my/id/eprint/17382/ http://umpir.ump.edu.my/id/eprint/17382/1/Effect%20of%20Seed%20Loading%20and%20Temperature%20of%20Seeding%20on%20Carbamazepine-Saccharin%20Co-Crystal.pdf

id	ump-17382
recordtype	eprints
spelling	ump-173822017-06-02T02:02:02Z http://umpir.ump.edu.my/id/eprint/17382/ Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal K. A., Mohammad Syarifah, Abd Rahim M. R., Abu Bakar TP Chemical technology Objectives: In pharmaceutical industries, the properties of desired final crystal can be modified by seeding process. Seeding activities depend on seed loading, seed size, seed quality and the temperature of supersaturated solution at the time of seed addition. The effect of amount of seed and temperature of seeding on crystallisation and size distribution of carbamazepine-saccharin (CBZ-SAC) co-crystals have been investigated. Methods/Statistical Analysis: 0.5, 1.0 and 1.5 wt% seeds of constant size were added to the metastable zone width region during cooling crystallisation at seeding temperatures of 38.45, 40.35, 42.25, 44.15 and 46.05 oC. Findings: During the crystallisation process of CBZ-SAC co-crystal, nucleation occurred faster when seeding is close to the super solubility curve which is at the highest supersaturation. Crystal size distribution (CSD) results showed more fine particles formed at 38.45oC seed temperature. On the other hand, nucleation occurred slower when seeding is close to the solubility curve, which is at low supersaturation and therefore resulted in less number of fine particles formed. Application: Nucleation of CBZ-SAC co-crystals can be controlled easily by seeding, in which the addition of seed expedites the crystallisation process by providing the surface area for crystals to grow. The size and characteristic of the desired crystal can be adjusted via seeding application. Informatics Publishing Limited 2017 Article PeerReviewed application/pdf en cc_by http://umpir.ump.edu.my/id/eprint/17382/1/Effect%20of%20Seed%20Loading%20and%20Temperature%20of%20Seeding%20on%20Carbamazepine-Saccharin%20Co-Crystal.pdf K. A., Mohammad and Syarifah, Abd Rahim and M. R., Abu Bakar (2017) Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal. Indian Journal of Science and Technology, 10 (6). pp. 1-5. ISSN 0974-6846 (Print); 0974-5645 (Online) http://www.indjst.org/index.php/indjst/article/view/111222 doi: 10.17485/ijst/2017/v10i6/111137
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology K. A., Mohammad Syarifah, Abd Rahim M. R., Abu Bakar Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal
description	Objectives: In pharmaceutical industries, the properties of desired final crystal can be modified by seeding process. Seeding activities depend on seed loading, seed size, seed quality and the temperature of supersaturated solution at the time of seed addition. The effect of amount of seed and temperature of seeding on crystallisation and size distribution of carbamazepine-saccharin (CBZ-SAC) co-crystals have been investigated. Methods/Statistical Analysis: 0.5, 1.0 and 1.5 wt% seeds of constant size were added to the metastable zone width region during cooling crystallisation at seeding temperatures of 38.45, 40.35, 42.25, 44.15 and 46.05 oC. Findings: During the crystallisation process of CBZ-SAC co-crystal, nucleation occurred faster when seeding is close to the super solubility curve which is at the highest supersaturation. Crystal size distribution (CSD) results showed more fine particles formed at 38.45oC seed temperature. On the other hand, nucleation occurred slower when seeding is close to the solubility curve, which is at low supersaturation and therefore resulted in less number of fine particles formed. Application: Nucleation of CBZ-SAC co-crystals can be controlled easily by seeding, in which the addition of seed expedites the crystallisation process by providing the surface area for crystals to grow. The size and characteristic of the desired crystal can be adjusted via seeding application.
format	Article
author	K. A., Mohammad Syarifah, Abd Rahim M. R., Abu Bakar
author_facet	K. A., Mohammad Syarifah, Abd Rahim M. R., Abu Bakar
author_sort	K. A., Mohammad
title	Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal
title_short	Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal
title_full	Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal
title_fullStr	Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal
title_full_unstemmed	Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal
title_sort	effect of seed loading and temperature of seeding on carbamazepine-saccharin co-crystal
publisher	Informatics Publishing Limited
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/17382/ http://umpir.ump.edu.my/id/eprint/17382/ http://umpir.ump.edu.my/id/eprint/17382/ http://umpir.ump.edu.my/id/eprint/17382/1/Effect%20of%20Seed%20Loading%20and%20Temperature%20of%20Seeding%20on%20Carbamazepine-Saccharin%20Co-Crystal.pdf
first_indexed	2023-09-18T22:23:58Z
last_indexed	2023-09-18T22:23:58Z
_version_	1777415841948631040

Effect of Seed Loading and Temperature of Seeding on Carbamazepine-Saccharin Co-Crystal

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