Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats

Boesenbergia rotunda (L.) Mansf. had been traditionally used as herbs to treat pain and rheumatism. Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) is a compound isolated from Boesenbergia rotunda (L.) Mansf.. Previous study had shown the potential of cardamonin in inhibiting the release of pro-infl...

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Main Authors:	Fui-Ling, Voon, Mohd Roslan, Sulaiman, Akhtar, Muhammad Nadeem, Mohamad Fauzi, Idris, Ahmad, Akira, Enoch Kumar, Perimal, Daud, Ahmad Israf, Lee, Ming-Tatt
Format:	Article
Language:	English
Published:	Elsevier Ltd 2017
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/16592/ http://umpir.ump.edu.my/id/eprint/16592/ http://umpir.ump.edu.my/id/eprint/16592/ http://umpir.ump.edu.my/id/eprint/16592/1/fist-2017-nadeem-Cardamonin%20%282%E2%80%B2%2C4%E2%80%B2-dihydroxy-6%E2%80%B2-methoxychalcone%29%20isolated1.pdf

id	ump-16592
recordtype	eprints
spelling	ump-165922017-12-29T04:58:32Z http://umpir.ump.edu.my/id/eprint/16592/ Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats Fui-Ling, Voon Mohd Roslan, Sulaiman Akhtar, Muhammad Nadeem Mohamad Fauzi, Idris Ahmad, Akira Enoch Kumar, Perimal Daud, Ahmad Israf Lee, Ming-Tatt Q Science (General) Boesenbergia rotunda (L.) Mansf. had been traditionally used as herbs to treat pain and rheumatism. Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) is a compound isolated from Boesenbergia rotunda (L.) Mansf.. Previous study had shown the potential of cardamonin in inhibiting the release of pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in vitro. Thus, the possible therapeutic effect of cardamonin in the rheumatoid arthritis (RA) joints is postulated. This study was performed to investigate the anti-arthritic properties of cardamonin in rat model of induced RA, particularly on the inflammatory and pain response of RA. Rheumatoid arthritis paw inflammation was induced by intraplantar (i.pl.) injection of complete Freund's adjuvant (CFA) in Sprague Dawley rats. Using four doses of cardamonin (0.625, 1.25, 2.5, and 5.0 mg/kg), anti-arthritic activity was evaluated through the paw edema, mechanical allodynia and thermal hyperalgesia responses. Enzyme-linked immunosorbent assay (ELISA) was carried out to evaluate the plasma level of TNF-α, IL-1β, and IL-6. Histological slides were prepared from the harvested rat paws to observe the arthritic changes in the joints. Behavioral, biochemical, and histological studies showed that cardamonin demonstrated significant inhibition on RA-induced inflammatory and pain responses as well as progression of joint destruction in rats. ELISA results showed that there was significant inhibition in TNF-α, IL-1β, and IL-6 levels in plasma of the cardamonin-treated RA rats. Overall, cardamonin possesses potential anti-arthritic properties in CFA-induced RA rat model. Elsevier Ltd 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16592/1/fist-2017-nadeem-Cardamonin%20%282%E2%80%B2%2C4%E2%80%B2-dihydroxy-6%E2%80%B2-methoxychalcone%29%20isolated1.pdf Fui-Ling, Voon and Mohd Roslan, Sulaiman and Akhtar, Muhammad Nadeem and Mohamad Fauzi, Idris and Ahmad, Akira and Enoch Kumar, Perimal and Daud, Ahmad Israf and Lee, Ming-Tatt (2017) Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats. European Journal of Pharmacology, 794. pp. 127-134. ISSN 0014-2999 http://doi.org/10.1016/j.ejphar.2016.11.009 DOI: 10.1016/j.ejphar.2016.11.009
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Fui-Ling, Voon Mohd Roslan, Sulaiman Akhtar, Muhammad Nadeem Mohamad Fauzi, Idris Ahmad, Akira Enoch Kumar, Perimal Daud, Ahmad Israf Lee, Ming-Tatt Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats
description	Boesenbergia rotunda (L.) Mansf. had been traditionally used as herbs to treat pain and rheumatism. Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) is a compound isolated from Boesenbergia rotunda (L.) Mansf.. Previous study had shown the potential of cardamonin in inhibiting the release of pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in vitro. Thus, the possible therapeutic effect of cardamonin in the rheumatoid arthritis (RA) joints is postulated. This study was performed to investigate the anti-arthritic properties of cardamonin in rat model of induced RA, particularly on the inflammatory and pain response of RA. Rheumatoid arthritis paw inflammation was induced by intraplantar (i.pl.) injection of complete Freund's adjuvant (CFA) in Sprague Dawley rats. Using four doses of cardamonin (0.625, 1.25, 2.5, and 5.0 mg/kg), anti-arthritic activity was evaluated through the paw edema, mechanical allodynia and thermal hyperalgesia responses. Enzyme-linked immunosorbent assay (ELISA) was carried out to evaluate the plasma level of TNF-α, IL-1β, and IL-6. Histological slides were prepared from the harvested rat paws to observe the arthritic changes in the joints. Behavioral, biochemical, and histological studies showed that cardamonin demonstrated significant inhibition on RA-induced inflammatory and pain responses as well as progression of joint destruction in rats. ELISA results showed that there was significant inhibition in TNF-α, IL-1β, and IL-6 levels in plasma of the cardamonin-treated RA rats. Overall, cardamonin possesses potential anti-arthritic properties in CFA-induced RA rat model.
format	Article
author	Fui-Ling, Voon Mohd Roslan, Sulaiman Akhtar, Muhammad Nadeem Mohamad Fauzi, Idris Ahmad, Akira Enoch Kumar, Perimal Daud, Ahmad Israf Lee, Ming-Tatt
author_facet	Fui-Ling, Voon Mohd Roslan, Sulaiman Akhtar, Muhammad Nadeem Mohamad Fauzi, Idris Ahmad, Akira Enoch Kumar, Perimal Daud, Ahmad Israf Lee, Ming-Tatt
author_sort	Fui-Ling, Voon
title	Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats
title_short	Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats
title_full	Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats
title_fullStr	Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats
title_full_unstemmed	Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats
title_sort	cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) isolated from boesenbergia rotunda (l.) mansf. inhibits cfa-induced rheumatoid arthritis in rats
publisher	Elsevier Ltd
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/16592/ http://umpir.ump.edu.my/id/eprint/16592/ http://umpir.ump.edu.my/id/eprint/16592/ http://umpir.ump.edu.my/id/eprint/16592/1/fist-2017-nadeem-Cardamonin%20%282%E2%80%B2%2C4%E2%80%B2-dihydroxy-6%E2%80%B2-methoxychalcone%29%20isolated1.pdf
first_indexed	2023-09-18T22:22:25Z
last_indexed	2023-09-18T22:22:25Z
_version_	1777415744486637568

Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) Isolated from Boesenbergia Rotunda (L.) Mansf. Inhibits CFA-induced Rheumatoid Arthritis in Rats

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