Moringa oleifera Lam: Targeting Chemoprevention

Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as ‘’murungai’’ or ‘’kelor’’. Glucomoringin, a glucosinolate with from M. oleifera is a major secondary metabolite compound. The seeds and leaves of the plant are reported...

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Main Authors:	Nurul Ashikin, Abd Karim, Muhammad Din, Ibrahim, Kntayya, Saie Brindha, Rukayadi, Yaya, Hazrulrizawati, Hamid, Ahmad Faizal, Abdull Razis
Format:	Article
Language:	English
Published:	Asian Pacific Organization for Cancer Prevention (APOCP) 2016
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://umpir.ump.edu.my/id/eprint/16444/ http://umpir.ump.edu.my/id/eprint/16444/ http://umpir.ump.edu.my/id/eprint/16444/1/3675-3686%201.3%20Nurul%20Ashikin%20Abd%20Karim%5BREVIEW%5D.pdf

id	ump-16444
recordtype	eprints
spelling	ump-164442017-02-20T06:37:54Z http://umpir.ump.edu.my/id/eprint/16444/ Moringa oleifera Lam: Targeting Chemoprevention Nurul Ashikin, Abd Karim Muhammad Din, Ibrahim Kntayya, Saie Brindha Rukayadi, Yaya Hazrulrizawati, Hamid Ahmad Faizal, Abdull Razis RM Therapeutics. Pharmacology Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as ‘’murungai’’ or ‘’kelor’’. Glucomoringin, a glucosinolate with from M. oleifera is a major secondary metabolite compound. The seeds and leaves of the plant are reported to have the highest amount of glucosinolates. M. oleifera is well known for its many uses health and benefits. It is claimed to have nutritional, medicinal and chemopreventive potentials. Chemopreventive effects of M. oleifera are expected due to the existence of glucosinolate which it is reported to have the ability to induce apoptosis in anticancer studies. Furthermore, chemopreventive value of M. oleifera has been demonstrated in studies utilizing its leaf extract to inhibit the growth of human cancer cell lines. This review highlights the advantages of M. oleifera targeting chemoprevention where glucosinolates could help to slow the process of carcinogenesis through several molecular targets. It is also includes inhibition of carcinogen activation and induction of carcinogen detoxification, anti-inflammatory, anti-tumor cell proliferation, induction of apoptosis and inhibition of tumor angiogenesis. Finally, for synergistic effects of M. oleifera with other drugs and safety, essential for chemoprevention, it is important that it safe to be consumed by human body and works well. Although there there were promising evident about M. oleifera in chemoprevention extensive research need to be done due to the expected rise of cancer in coming years and to gain more information about the mechanisms involved in M. oleifera influence, which could be a good source to inhibit several major mechanisms involved in cancer development. Asian Pacific Organization for Cancer Prevention (APOCP) 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16444/1/3675-3686%201.3%20Nurul%20Ashikin%20Abd%20Karim%5BREVIEW%5D.pdf Nurul Ashikin, Abd Karim and Muhammad Din, Ibrahim and Kntayya, Saie Brindha and Rukayadi, Yaya and Hazrulrizawati, Hamid and Ahmad Faizal, Abdull Razis (2016) Moringa oleifera Lam: Targeting Chemoprevention. Asian Pacific Journal of Cancer Prevention, 17 (8). pp. 3675-3686. http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:27644601&key=2016.17.8.3675
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Nurul Ashikin, Abd Karim Muhammad Din, Ibrahim Kntayya, Saie Brindha Rukayadi, Yaya Hazrulrizawati, Hamid Ahmad Faizal, Abdull Razis Moringa oleifera Lam: Targeting Chemoprevention
description	Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as ‘’murungai’’ or ‘’kelor’’. Glucomoringin, a glucosinolate with from M. oleifera is a major secondary metabolite compound. The seeds and leaves of the plant are reported to have the highest amount of glucosinolates. M. oleifera is well known for its many uses health and benefits. It is claimed to have nutritional, medicinal and chemopreventive potentials. Chemopreventive effects of M. oleifera are expected due to the existence of glucosinolate which it is reported to have the ability to induce apoptosis in anticancer studies. Furthermore, chemopreventive value of M. oleifera has been demonstrated in studies utilizing its leaf extract to inhibit the growth of human cancer cell lines. This review highlights the advantages of M. oleifera targeting chemoprevention where glucosinolates could help to slow the process of carcinogenesis through several molecular targets. It is also includes inhibition of carcinogen activation and induction of carcinogen detoxification, anti-inflammatory, anti-tumor cell proliferation, induction of apoptosis and inhibition of tumor angiogenesis. Finally, for synergistic effects of M. oleifera with other drugs and safety, essential for chemoprevention, it is important that it safe to be consumed by human body and works well. Although there there were promising evident about M. oleifera in chemoprevention extensive research need to be done due to the expected rise of cancer in coming years and to gain more information about the mechanisms involved in M. oleifera influence, which could be a good source to inhibit several major mechanisms involved in cancer development.
format	Article
author	Nurul Ashikin, Abd Karim Muhammad Din, Ibrahim Kntayya, Saie Brindha Rukayadi, Yaya Hazrulrizawati, Hamid Ahmad Faizal, Abdull Razis
author_facet	Nurul Ashikin, Abd Karim Muhammad Din, Ibrahim Kntayya, Saie Brindha Rukayadi, Yaya Hazrulrizawati, Hamid Ahmad Faizal, Abdull Razis
author_sort	Nurul Ashikin, Abd Karim
title	Moringa oleifera Lam: Targeting Chemoprevention
title_short	Moringa oleifera Lam: Targeting Chemoprevention
title_full	Moringa oleifera Lam: Targeting Chemoprevention
title_fullStr	Moringa oleifera Lam: Targeting Chemoprevention
title_full_unstemmed	Moringa oleifera Lam: Targeting Chemoprevention
title_sort	moringa oleifera lam: targeting chemoprevention
publisher	Asian Pacific Organization for Cancer Prevention (APOCP)
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/16444/ http://umpir.ump.edu.my/id/eprint/16444/ http://umpir.ump.edu.my/id/eprint/16444/1/3675-3686%201.3%20Nurul%20Ashikin%20Abd%20Karim%5BREVIEW%5D.pdf
first_indexed	2023-09-18T22:22:07Z
last_indexed	2023-09-18T22:22:07Z
_version_	1777415726484684800

Moringa oleifera Lam: Targeting Chemoprevention

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