Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans

Clinacanthus nutans has been used in traditional herbal medicine for cancer prevention, but the specific bioactive compounds responsible for the observed activities have not been explored. Different polar solvents such as methanol, chloroform, ethyl acetate, and hexane were used for the extraction....

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Main Authors:	Hazrulrizawati, Hamid, Izzah Hayati, Yahaya, M. M., Yusoff, Seema, Zareen
Format:	Article
Language:	English
Published:	Wiley 2016
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/16242/ http://umpir.ump.edu.my/id/eprint/16242/ http://umpir.ump.edu.my/id/eprint/16242/6/fist-2016-hazrul-bioassay.pdf

id	ump-16242
recordtype	eprints
spelling	ump-162422018-07-26T07:50:33Z http://umpir.ump.edu.my/id/eprint/16242/ Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans Hazrulrizawati, Hamid Izzah Hayati, Yahaya M. M., Yusoff Seema, Zareen QD Chemistry Clinacanthus nutans has been used in traditional herbal medicine for cancer prevention, but the specific bioactive compounds responsible for the observed activities have not been explored. Different polar solvents such as methanol, chloroform, ethyl acetate, and hexane were used for the extraction. The extracts, fractions, and isolated compounds were subjected to DPPH and ferric reducing antioxidant potential (FRAP) assays. Methanol extracts show significant free-radical scavenging activity of 69.09% in DPPH and 56.49% FRAP. Purification of MeOH extracts afforded the fraction FB28 and two new sulfur-containing compounds, named clinamide D and E (1, 2). Compound (1) proved to be more active with an IC50 value for DPPH radical scavenging of 118.27 ± 0.01 µg/mL and reduction of Fe3+–TPTZ complex of 386.24 ± 0.02, higher than that of the standard ascorbic acid. Sulfur-containing compounds isolated from C. nutans is a potential natural antioxidant. Wiley 2016-11-16 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16242/6/fist-2016-hazrul-bioassay.pdf Hazrulrizawati, Hamid and Izzah Hayati, Yahaya and M. M., Yusoff and Seema, Zareen (2016) Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans. Journal of the Chinese Chemical Society, 63 (12). pp. 1033-1037. ISSN 2192-6549 http://dx.doi.org/10.1002/jccs.201600755
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Hazrulrizawati, Hamid Izzah Hayati, Yahaya M. M., Yusoff Seema, Zareen Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans
description	Clinacanthus nutans has been used in traditional herbal medicine for cancer prevention, but the specific bioactive compounds responsible for the observed activities have not been explored. Different polar solvents such as methanol, chloroform, ethyl acetate, and hexane were used for the extraction. The extracts, fractions, and isolated compounds were subjected to DPPH and ferric reducing antioxidant potential (FRAP) assays. Methanol extracts show significant free-radical scavenging activity of 69.09% in DPPH and 56.49% FRAP. Purification of MeOH extracts afforded the fraction FB28 and two new sulfur-containing compounds, named clinamide D and E (1, 2). Compound (1) proved to be more active with an IC50 value for DPPH radical scavenging of 118.27 ± 0.01 µg/mL and reduction of Fe3+–TPTZ complex of 386.24 ± 0.02, higher than that of the standard ascorbic acid. Sulfur-containing compounds isolated from C. nutans is a potential natural antioxidant.
format	Article
author	Hazrulrizawati, Hamid Izzah Hayati, Yahaya M. M., Yusoff Seema, Zareen
author_facet	Hazrulrizawati, Hamid Izzah Hayati, Yahaya M. M., Yusoff Seema, Zareen
author_sort	Hazrulrizawati, Hamid
title	Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans
title_short	Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans
title_full	Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans
title_fullStr	Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans
title_full_unstemmed	Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans
title_sort	bioassay-guided isolation and antioxidant activity of sulfur-containing compounds from clinacanthus nutans
publisher	Wiley
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/16242/ http://umpir.ump.edu.my/id/eprint/16242/ http://umpir.ump.edu.my/id/eprint/16242/6/fist-2016-hazrul-bioassay.pdf
first_indexed	2023-09-18T22:21:44Z
last_indexed	2023-09-18T22:21:44Z
_version_	1777415702222733312

Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans

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