Adverse Effects of Tannin Contained in Mimosa pudica Root Extract

Adverse Effects of Tannin Contained in Mimosa pudica Root Extract

Background and Objective: Mimosa pudica has been used for many traditional healings including snake bites, wound healing, treating bleeding piles, ulcers, diarrhea, anti-inflammatory, anti-diabetic, anti-oxidant and anti-microbial etc. Tannin extracted from plants been beneficial as therapeutics wit...

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Main Author: Jaya Vejayan, Palliah
Format: Article
Language:English
Published: Asian Network for Scientific Information 2016
Subjects:
Q Science (General)
Online Access:http://umpir.ump.edu.my/id/eprint/16007/
http://umpir.ump.edu.my/id/eprint/16007/
http://umpir.ump.edu.my/id/eprint/16007/
http://umpir.ump.edu.my/id/eprint/16007/4/477-483.pdf
id ump-16007
recordtype eprints
spelling ump-160072017-09-11T04:05:01Z http://umpir.ump.edu.my/id/eprint/16007/ Adverse Effects of Tannin Contained in Mimosa pudica Root Extract Jaya Vejayan, Palliah Q Science (General) Background and Objective: Mimosa pudica has been used for many traditional healings including snake bites, wound healing, treating bleeding piles, ulcers, diarrhea, anti-inflammatory, anti-diabetic, anti-oxidant and anti-microbial etc. Tannin extracted from plants been beneficial as therapeutics with dividing opinions on its safety. Hence, this study investigated the safety of the total tannin extracted from the root of Mimosa pudica plant. Methodology: This investigation utilized biochemical markers as well as cytotoxicity and histopatological experiments. Additionally, the total condensed and hydrolysable tannins determined in the particular root extract of the Mimosa pudica plant. Results: Extract of MPT at the highest dose tested 2.5 mg mL–1 elevated significantly the levels of mice serum contained ALT and AST while no observable changes to ALP and GGT levels detected. The cytotoxicity of MPT was found to be with CTC50 values of 0.0653 and 0.119 mg mL–1 in vero and MDCK cell lines, respectively. The mice organ’s histopathology of liver and kidney demonstrated MPT having distinct toxic effects at the highest concentration tested. The total tannin in MPT found to be 3.28 mg TAE g–1 dry weight with more hydrolysable type of tannin than condensed tannin 0.31 TAE/dry weight. Conclusion: The MPT found to show adverse effects in all experiments conducted at the highest concentration of 2.5 mg mL–1. Hence, the age old doubt regarding the adverse effects of tannin being proven here whereby it was discovered the use of Mimosa pudica total tannin is concentration dependent. Therefore, warranted prior caution in determining the safe levels of tannin required before usage. Asian Network for Scientific Information 2016-09-15 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16007/4/477-483.pdf Jaya Vejayan, Palliah (2016) Adverse Effects of Tannin Contained in Mimosa pudica Root Extract. Journal of Applied Sciences, 16 (10). pp. 477-483. ISSN 1812-5654 (print); 1812-5662 (online) http://dx.doi.org/10.3923/jas.2016.477.483 doi: 10.3923/jas.2016.477.483
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic Q Science (General)
spellingShingle Q Science (General)
Jaya Vejayan, Palliah
Adverse Effects of Tannin Contained in Mimosa pudica Root Extract
description Background and Objective: Mimosa pudica has been used for many traditional healings including snake bites, wound healing, treating bleeding piles, ulcers, diarrhea, anti-inflammatory, anti-diabetic, anti-oxidant and anti-microbial etc. Tannin extracted from plants been beneficial as therapeutics with dividing opinions on its safety. Hence, this study investigated the safety of the total tannin extracted from the root of Mimosa pudica plant. Methodology: This investigation utilized biochemical markers as well as cytotoxicity and histopatological experiments. Additionally, the total condensed and hydrolysable tannins determined in the particular root extract of the Mimosa pudica plant. Results: Extract of MPT at the highest dose tested 2.5 mg mL–1 elevated significantly the levels of mice serum contained ALT and AST while no observable changes to ALP and GGT levels detected. The cytotoxicity of MPT was found to be with CTC50 values of 0.0653 and 0.119 mg mL–1 in vero and MDCK cell lines, respectively. The mice organ’s histopathology of liver and kidney demonstrated MPT having distinct toxic effects at the highest concentration tested. The total tannin in MPT found to be 3.28 mg TAE g–1 dry weight with more hydrolysable type of tannin than condensed tannin 0.31 TAE/dry weight. Conclusion: The MPT found to show adverse effects in all experiments conducted at the highest concentration of 2.5 mg mL–1. Hence, the age old doubt regarding the adverse effects of tannin being proven here whereby it was discovered the use of Mimosa pudica total tannin is concentration dependent. Therefore, warranted prior caution in determining the safe levels of tannin required before usage.
format Article
author Jaya Vejayan, Palliah
author_facet Jaya Vejayan, Palliah
author_sort Jaya Vejayan, Palliah
title Adverse Effects of Tannin Contained in Mimosa pudica Root Extract
title_short Adverse Effects of Tannin Contained in Mimosa pudica Root Extract
title_full Adverse Effects of Tannin Contained in Mimosa pudica Root Extract
title_fullStr Adverse Effects of Tannin Contained in Mimosa pudica Root Extract
title_full_unstemmed Adverse Effects of Tannin Contained in Mimosa pudica Root Extract
title_sort adverse effects of tannin contained in mimosa pudica root extract
publisher Asian Network for Scientific Information
publishDate 2016
url http://umpir.ump.edu.my/id/eprint/16007/
http://umpir.ump.edu.my/id/eprint/16007/
http://umpir.ump.edu.my/id/eprint/16007/
http://umpir.ump.edu.my/id/eprint/16007/4/477-483.pdf
first_indexed 2023-09-18T22:21:18Z
last_indexed 2023-09-18T22:21:18Z
_version_ 1777415674332708864

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