Small Molecules with Potential Biological Activities

Natural products are unique source for drugs discovery. Several small molecules such as anthraquinones flavokawain B and curcumin related compounds exhibited tremendous biological activities. Curcumin and related compounds containing 1,3-diketone moiety, which is also essential biological activities...

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Main Authors:	Akhtar, Muhammad Nadeem, Swee, Keong Yeap, Seema, Zareen, Siti Noor Hajar, Zamrus, Addila, Abu Bakar, Saiful Nizam, Tajuddin, Noorjahan Banu, Alitheen
Format:	Conference or Workshop Item
Language:	English
Published:	2016
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/14269/ http://umpir.ump.edu.my/id/eprint/14269/1/Small%20Molecules%20with%20Potential%20Biological%20Activities.pdf

id	ump-14269
recordtype	eprints
spelling	ump-142692019-10-30T04:14:26Z http://umpir.ump.edu.my/id/eprint/14269/ Small Molecules with Potential Biological Activities Akhtar, Muhammad Nadeem Swee, Keong Yeap Seema, Zareen Siti Noor Hajar, Zamrus Addila, Abu Bakar Saiful Nizam, Tajuddin Noorjahan Banu, Alitheen Q Science (General) Natural products are unique source for drugs discovery. Several small molecules such as anthraquinones flavokawain B and curcumin related compounds exhibited tremendous biological activities. Curcumin and related compounds containing 1,3-diketone moiety, which is also essential biological activities possessing various pharmacological activities such as anti-cancer, anti-inflammatory, anti-oxidant and anti-diabetic properties. Various naturally occurring compounds have been synthesized and investigated for their cytotoxic properties against breast cancer cell lines MDA-MB231 cells. A series of mono-carbonyl curcuminoids analogs have been synthesized by Claisen Schmidt condensation reaction by using acid or base catalysed reaction. Various analogues especially 2,6-bis(4-bromobenzylidene)cyclohexanone, 1,5-bis(4-hydroxy-3- methoxyphenyl) penta-1,4-dien-3-one and 1,5-bis(2,5-dimethoxyphenyl)penta-1,4-diene-3- one showed the potential anticancer activity. Together, these results some natural compounds isolated from Knema laurina showed acetylcholinesterase inhibitory activities. The compounds were purified by column chromatography and their structures were determined by 1H NMR, GC-MS, and single X-ray analysis techniques. 2016 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/14269/1/Small%20Molecules%20with%20Potential%20Biological%20Activities.pdf Akhtar, Muhammad Nadeem and Swee, Keong Yeap and Seema, Zareen and Siti Noor Hajar, Zamrus and Addila, Abu Bakar and Saiful Nizam, Tajuddin and Noorjahan Banu, Alitheen (2016) Small Molecules with Potential Biological Activities. In: International Conference in Organic Synthesis Malaysia, 21-24 August 2016 , Kuching, Sarawak. . (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Akhtar, Muhammad Nadeem Swee, Keong Yeap Seema, Zareen Siti Noor Hajar, Zamrus Addila, Abu Bakar Saiful Nizam, Tajuddin Noorjahan Banu, Alitheen Small Molecules with Potential Biological Activities
description	Natural products are unique source for drugs discovery. Several small molecules such as anthraquinones flavokawain B and curcumin related compounds exhibited tremendous biological activities. Curcumin and related compounds containing 1,3-diketone moiety, which is also essential biological activities possessing various pharmacological activities such as anti-cancer, anti-inflammatory, anti-oxidant and anti-diabetic properties. Various naturally occurring compounds have been synthesized and investigated for their cytotoxic properties against breast cancer cell lines MDA-MB231 cells. A series of mono-carbonyl curcuminoids analogs have been synthesized by Claisen Schmidt condensation reaction by using acid or base catalysed reaction. Various analogues especially 2,6-bis(4-bromobenzylidene)cyclohexanone, 1,5-bis(4-hydroxy-3- methoxyphenyl) penta-1,4-dien-3-one and 1,5-bis(2,5-dimethoxyphenyl)penta-1,4-diene-3- one showed the potential anticancer activity. Together, these results some natural compounds isolated from Knema laurina showed acetylcholinesterase inhibitory activities. The compounds were purified by column chromatography and their structures were determined by 1H NMR, GC-MS, and single X-ray analysis techniques.
format	Conference or Workshop Item
author	Akhtar, Muhammad Nadeem Swee, Keong Yeap Seema, Zareen Siti Noor Hajar, Zamrus Addila, Abu Bakar Saiful Nizam, Tajuddin Noorjahan Banu, Alitheen
author_facet	Akhtar, Muhammad Nadeem Swee, Keong Yeap Seema, Zareen Siti Noor Hajar, Zamrus Addila, Abu Bakar Saiful Nizam, Tajuddin Noorjahan Banu, Alitheen
author_sort	Akhtar, Muhammad Nadeem
title	Small Molecules with Potential Biological Activities
title_short	Small Molecules with Potential Biological Activities
title_full	Small Molecules with Potential Biological Activities
title_fullStr	Small Molecules with Potential Biological Activities
title_full_unstemmed	Small Molecules with Potential Biological Activities
title_sort	small molecules with potential biological activities
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/14269/ http://umpir.ump.edu.my/id/eprint/14269/1/Small%20Molecules%20with%20Potential%20Biological%20Activities.pdf
first_indexed	2023-09-18T22:17:50Z
last_indexed	2023-09-18T22:17:50Z
_version_	1777415456130334720

Small Molecules with Potential Biological Activities

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