Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors

Tooth decay is considered the most widespread infectious disease in the world. This study aims to isolate and identify the important bacteria related to tooth decay, determine the sensitivity of bacteria in certain types of antimicrobial agents, and study the effect of heavy metals on bacterial is...

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Main Authors:	Ali, Muna Jalal, Makky, Essam A., Batool, Tahira, M. M., Yusoff
Format:	Article
Language:	English
Published:	JOCPR 2015
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/12762/ http://umpir.ump.edu.my/id/eprint/12762/ http://umpir.ump.edu.my/id/eprint/12762/1/JCPR-2015-7-3-1822-1829.pdf

id	ump-12762
recordtype	eprints
spelling	ump-127622018-07-26T06:46:11Z http://umpir.ump.edu.my/id/eprint/12762/ Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors Ali, Muna Jalal Makky, Essam A. Batool, Tahira M. M., Yusoff Q Science (General) Tooth decay is considered the most widespread infectious disease in the world. This study aims to isolate and identify the important bacteria related to tooth decay, determine the sensitivity of bacteria in certain types of antimicrobial agents, and study the effect of heavy metals on bacterial isolates. A total of 50 swabs were collected from the mouths of patients from both sexes, with ages ranging from 1–60 years. The patients were advised to consult with dental clinics and specialized centers to isolate and identify the causative agents associated with oral diseases. Results showed that infection rates in younger age groups (1–20 and 20–40) are higher than the elder group (40–60), with percent incidence of 44% and 32%, respectively. Antibiotic sensitivity test against the isolates showed that chloramphenicol had the highest sensitivity effect with 83.2% followed by rifampicin and gentamicin with 81.35%, penicillin G with 64.40%, and streptomycin with 16.94%. In addition, 100% resistance was recorded against seven heavy metals, including silver nitrate, iron chloride, zinc chloride, and lead acetate. The sensitivity to mercury, cadmium, and copper sulfate were 100%, 86.44%, and 1.69%, respectively. Hemolysin had the highest ability to produce virulence factors (72.88%), followed by lecithinase (42.37%) and protease (25.42%). Lipase and urease had the lowest virulence factor production (10.16%). JOCPR 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/12762/1/JCPR-2015-7-3-1822-1829.pdf Ali, Muna Jalal and Makky, Essam A. and Batool, Tahira and M. M., Yusoff (2015) Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors. Journal of Chemical and Pharmaceutical Research, 7 (3). pp. 1822-1829. ISSN 0975-7384 http://jocpr.com/vol7-iss3-2015/JCPR-2015-7-3-1822-1829.pdf
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Ali, Muna Jalal Makky, Essam A. Batool, Tahira M. M., Yusoff Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors
description	Tooth decay is considered the most widespread infectious disease in the world. This study aims to isolate and identify the important bacteria related to tooth decay, determine the sensitivity of bacteria in certain types of antimicrobial agents, and study the effect of heavy metals on bacterial isolates. A total of 50 swabs were collected from the mouths of patients from both sexes, with ages ranging from 1–60 years. The patients were advised to consult with dental clinics and specialized centers to isolate and identify the causative agents associated with oral diseases. Results showed that infection rates in younger age groups (1–20 and 20–40) are higher than the elder group (40–60), with percent incidence of 44% and 32%, respectively. Antibiotic sensitivity test against the isolates showed that chloramphenicol had the highest sensitivity effect with 83.2% followed by rifampicin and gentamicin with 81.35%, penicillin G with 64.40%, and streptomycin with 16.94%. In addition, 100% resistance was recorded against seven heavy metals, including silver nitrate, iron chloride, zinc chloride, and lead acetate. The sensitivity to mercury, cadmium, and copper sulfate were 100%, 86.44%, and 1.69%, respectively. Hemolysin had the highest ability to produce virulence factors (72.88%), followed by lecithinase (42.37%) and protease (25.42%). Lipase and urease had the lowest virulence factor production (10.16%).
format	Article
author	Ali, Muna Jalal Makky, Essam A. Batool, Tahira M. M., Yusoff
author_facet	Ali, Muna Jalal Makky, Essam A. Batool, Tahira M. M., Yusoff
author_sort	Ali, Muna Jalal
title	Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors
title_short	Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors
title_full	Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors
title_fullStr	Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors
title_full_unstemmed	Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors
title_sort	susceptibility of oral bacteria to antimicrobial agents and virulence factors
publisher	JOCPR
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/12762/ http://umpir.ump.edu.my/id/eprint/12762/ http://umpir.ump.edu.my/id/eprint/12762/1/JCPR-2015-7-3-1822-1829.pdf
first_indexed	2023-09-18T22:14:40Z
last_indexed	2023-09-18T22:14:40Z
_version_	1777415257406308352

Susceptibility of Oral Bacteria to Antimicrobial Agents and Virulence Factors

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