New Insights into Seaweed Polyphenols on Glucose Homeostasis

Context: Polyphenol-rich marine macroalgae are gaining dietary importance due to their influence over diabetes mellitus and the role as a vital source of high-value nutraceuticals. Their assorted beneficial effects on human health include competitive inhibition of digestive enzymes, varying the a...

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Main Authors:	Murugan, Amarchand Chordia, Karim, Md. Rezaul, M. M., Yusoff, Tan, Suat Hian, Mohd Fazli, Farida Asras, Rashid, Shah Samiur
Format:	Article
Language:	English
Published:	Informa Healthcare USA 2015
Subjects:	Q Science (General) RM Therapeutics. Pharmacology
Online Access:	http://umpir.ump.edu.my/id/eprint/12665/ http://umpir.ump.edu.my/id/eprint/12665/ http://umpir.ump.edu.my/id/eprint/12665/ http://umpir.ump.edu.my/id/eprint/12665/1/New%20Insights%20Into%20Seaweed%20Polyphenols%20on%20Glucose%20Homeostasis.pdf

id	ump-12665
recordtype	eprints
spelling	ump-126652018-06-29T08:21:51Z http://umpir.ump.edu.my/id/eprint/12665/ New Insights into Seaweed Polyphenols on Glucose Homeostasis Murugan, Amarchand Chordia Karim, Md. Rezaul M. M., Yusoff Tan, Suat Hian Mohd Fazli, Farida Asras Rashid, Shah Samiur Q Science (General) RM Therapeutics. Pharmacology Context: Polyphenol-rich marine macroalgae are gaining dietary importance due to their influence over diabetes mellitus and the role as a vital source of high-value nutraceuticals. Their assorted beneficial effects on human health include competitive inhibition of digestive enzymes, varying the activity of hepatic glucose-metabolizing enzymes, lowering the plasma glucose levels, and lipid peroxidation, delaying the aging process. Objective: In this paper, we review the health beneficial effects of polyphenols and phlorotannins from brown seaweeds with special emphasis on their inhibitory effects on carbohydrate-metabolizing enzymes. Methods: A survey of literature from databases such as Sciencedirect, Scopus, Pubmed, Springerlink, and Google Scholar from the year 1973 to 2013 was done to bring together the information relating to drug discovery from brown seaweeds as a source for diabetes treatment. Results: Over the past two decades, 20 different bioactive polyphenols/phlorotannins have been isolated and studied from 10 different brown algae. Discussion of the positive effect on the inhibition of enzymes metabolizing carbohydrates in both in vitro and in vivo experiments are included. Conclusion: Despite the recent advancements in isolating bioactive compounds from seaweeds with potential health benefit or pharmaceutical behavior, studies on the polyphenol effectiveness on glucose homeostasis in human beings are very few in response to their functional characterization. Added research in this area is required to confirm the close connection of polyphenol rich seaweed-based diet consumption with glucose homeostasis and the exciting possibility of prescribing polyphenols to treat the diabetes pandemic. Informa Healthcare USA 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/12665/1/New%20Insights%20Into%20Seaweed%20Polyphenols%20on%20Glucose%20Homeostasis.pdf Murugan, Amarchand Chordia and Karim, Md. Rezaul and M. M., Yusoff and Tan, Suat Hian and Mohd Fazli, Farida Asras and Rashid, Shah Samiur (2015) New Insights into Seaweed Polyphenols on Glucose Homeostasis. Pharmaceutical Biology, 53 (8). pp. 1087-1097. ISSN 1388-0209 http://dx.doi.org/10.3109/13880209.2014.959615 DOI: 10.3109/13880209.2014.959615
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General) RM Therapeutics. Pharmacology
spellingShingle	Q Science (General) RM Therapeutics. Pharmacology Murugan, Amarchand Chordia Karim, Md. Rezaul M. M., Yusoff Tan, Suat Hian Mohd Fazli, Farida Asras Rashid, Shah Samiur New Insights into Seaweed Polyphenols on Glucose Homeostasis
description	Context: Polyphenol-rich marine macroalgae are gaining dietary importance due to their influence over diabetes mellitus and the role as a vital source of high-value nutraceuticals. Their assorted beneficial effects on human health include competitive inhibition of digestive enzymes, varying the activity of hepatic glucose-metabolizing enzymes, lowering the plasma glucose levels, and lipid peroxidation, delaying the aging process. Objective: In this paper, we review the health beneficial effects of polyphenols and phlorotannins from brown seaweeds with special emphasis on their inhibitory effects on carbohydrate-metabolizing enzymes. Methods: A survey of literature from databases such as Sciencedirect, Scopus, Pubmed, Springerlink, and Google Scholar from the year 1973 to 2013 was done to bring together the information relating to drug discovery from brown seaweeds as a source for diabetes treatment. Results: Over the past two decades, 20 different bioactive polyphenols/phlorotannins have been isolated and studied from 10 different brown algae. Discussion of the positive effect on the inhibition of enzymes metabolizing carbohydrates in both in vitro and in vivo experiments are included. Conclusion: Despite the recent advancements in isolating bioactive compounds from seaweeds with potential health benefit or pharmaceutical behavior, studies on the polyphenol effectiveness on glucose homeostasis in human beings are very few in response to their functional characterization. Added research in this area is required to confirm the close connection of polyphenol rich seaweed-based diet consumption with glucose homeostasis and the exciting possibility of prescribing polyphenols to treat the diabetes pandemic.
format	Article
author	Murugan, Amarchand Chordia Karim, Md. Rezaul M. M., Yusoff Tan, Suat Hian Mohd Fazli, Farida Asras Rashid, Shah Samiur
author_facet	Murugan, Amarchand Chordia Karim, Md. Rezaul M. M., Yusoff Tan, Suat Hian Mohd Fazli, Farida Asras Rashid, Shah Samiur
author_sort	Murugan, Amarchand Chordia
title	New Insights into Seaweed Polyphenols on Glucose Homeostasis
title_short	New Insights into Seaweed Polyphenols on Glucose Homeostasis
title_full	New Insights into Seaweed Polyphenols on Glucose Homeostasis
title_fullStr	New Insights into Seaweed Polyphenols on Glucose Homeostasis
title_full_unstemmed	New Insights into Seaweed Polyphenols on Glucose Homeostasis
title_sort	new insights into seaweed polyphenols on glucose homeostasis
publisher	Informa Healthcare USA
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/12665/ http://umpir.ump.edu.my/id/eprint/12665/ http://umpir.ump.edu.my/id/eprint/12665/ http://umpir.ump.edu.my/id/eprint/12665/1/New%20Insights%20Into%20Seaweed%20Polyphenols%20on%20Glucose%20Homeostasis.pdf
first_indexed	2023-09-18T22:14:30Z
last_indexed	2023-09-18T22:14:30Z
_version_	1777415247239315456

New Insights into Seaweed Polyphenols on Glucose Homeostasis

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