Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production

Biopharmaceutical industries consistently demand Water for Injection (WFI) in their production. WFI production requires large amount of energy that may leave environmental footprint. However, its potential environmental impact (PEI) is typically not included in environmental assessment. This paper a...

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Main Authors:	A., Idris, Chua, Gek Kee, Mohamad Rizza, Othman
Format:	Article
Language:	English
Published:	Elsevier 2016
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/11989/ http://umpir.ump.edu.my/id/eprint/11989/ http://umpir.ump.edu.my/id/eprint/11989/ http://umpir.ump.edu.my/id/eprint/11989/1/Incorporating%20Potential%20Environmental%20Impact%20from%20Water%20for%20Injection%20in%20Environmental%20Assessment%20of%20Monoclonal%20Antibody%20Production.pdf

id	ump-11989
recordtype	eprints
spelling	ump-119892018-05-14T04:26:36Z http://umpir.ump.edu.my/id/eprint/11989/ Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production A., Idris Chua, Gek Kee Mohamad Rizza, Othman TP Chemical technology Biopharmaceutical industries consistently demand Water for Injection (WFI) in their production. WFI production requires large amount of energy that may leave environmental footprint. However, its potential environmental impact (PEI) is typically not included in environmental assessment. This paper aims to present how WFI generation would contribute to environmental pollution. It was assumed that WFI was generated in Multiple Effect Distillation (MED), where utility steam is used as heating media. Utility steam is generated in a steam boiler, where several gas pollutants are produced as by-product. The PEI of these pollutants was estimated based on a modified Waste Reduction (WAR) Algorithm. For data generation, MED was simulated in SuperPro Designer®. To demonstrate the way to include WFI into an environmental assessment, a hypothetical monoclonal antibody process was used as a case-study. From the case-study, it can be seen that WFI generation contributed the most to energy consumption and to the total PEI value. Therefore, it is important to include PEI from WFI in the environmental assessment for more accurate results, particularly when comparing several process designs as the results may influence decision-making. Elsevier 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/11989/1/Incorporating%20Potential%20Environmental%20Impact%20from%20Water%20for%20Injection%20in%20Environmental%20Assessment%20of%20Monoclonal%20Antibody%20Production.pdf A., Idris and Chua, Gek Kee and Mohamad Rizza, Othman (2016) Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production. Chemical Engineering Research and Design. ISSN 0263-8762 (In Press) http://dx.doi.org/10.1016/j.cherd.2016.02.014 DOI: 10.1016/j.cherd.2016.02.014
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology A., Idris Chua, Gek Kee Mohamad Rizza, Othman Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production
description	Biopharmaceutical industries consistently demand Water for Injection (WFI) in their production. WFI production requires large amount of energy that may leave environmental footprint. However, its potential environmental impact (PEI) is typically not included in environmental assessment. This paper aims to present how WFI generation would contribute to environmental pollution. It was assumed that WFI was generated in Multiple Effect Distillation (MED), where utility steam is used as heating media. Utility steam is generated in a steam boiler, where several gas pollutants are produced as by-product. The PEI of these pollutants was estimated based on a modified Waste Reduction (WAR) Algorithm. For data generation, MED was simulated in SuperPro Designer®. To demonstrate the way to include WFI into an environmental assessment, a hypothetical monoclonal antibody process was used as a case-study. From the case-study, it can be seen that WFI generation contributed the most to energy consumption and to the total PEI value. Therefore, it is important to include PEI from WFI in the environmental assessment for more accurate results, particularly when comparing several process designs as the results may influence decision-making.
format	Article
author	A., Idris Chua, Gek Kee Mohamad Rizza, Othman
author_facet	A., Idris Chua, Gek Kee Mohamad Rizza, Othman
author_sort	A., Idris
title	Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production
title_short	Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production
title_full	Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production
title_fullStr	Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production
title_full_unstemmed	Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production
title_sort	incorporating potential environmental impact from water for injection in environmental assessment of monoclonal antibody production
publisher	Elsevier
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/11989/ http://umpir.ump.edu.my/id/eprint/11989/ http://umpir.ump.edu.my/id/eprint/11989/ http://umpir.ump.edu.my/id/eprint/11989/1/Incorporating%20Potential%20Environmental%20Impact%20from%20Water%20for%20Injection%20in%20Environmental%20Assessment%20of%20Monoclonal%20Antibody%20Production.pdf
first_indexed	2023-09-18T22:13:08Z
last_indexed	2023-09-18T22:13:08Z
_version_	1777415160521031680

Incorporating Potential Environmental Impact from Water for Injection in Environmental Assessment of Monoclonal Antibody Production

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