Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product

Monascuspurpureus is a non-pathogenic fungus that can produce statin called simvastatin, which can lower blood cholesterol level. The objectives of this research were to explore the potential of agricultural product on simvastatin and identify the optimal condition of simvastatin production in solid...

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Main Author:	Farhan, Mohd Said
Format:	Article
Language:	English English
Published:	Malaysian Technical Universities Network (MTUN) 2015
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/11847/ http://umpir.ump.edu.my/id/eprint/11847/ http://umpir.ump.edu.my/id/eprint/11847/1/Development%20of%20Simvastatin%20Production%20by%20Monascus%20Purpureus%20In%20Solid-State%20Fermentation%20Using%20Agricultural%20Product.pdf http://umpir.ump.edu.my/id/eprint/11847/7/fkksa-2015-fmsaid-Development%20of%20Simvastatin.pdf

id	ump-11847
recordtype	eprints
spelling	ump-118472018-02-08T07:19:53Z http://umpir.ump.edu.my/id/eprint/11847/ Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product Farhan, Mohd Said TP Chemical technology Monascuspurpureus is a non-pathogenic fungus that can produce statin called simvastatin, which can lower blood cholesterol level. The objectives of this research were to explore the potential of agricultural product on simvastatin and identify the optimal condition of simvastatin production in solid-state fermentation by Monascuspurpureus FTC 5356. The local agricultural products used were banana, guava, pumpkin, coconut meat, corn and papaya. Initially, the local agricultural products were ground and the initial moisture content of the agricultural products was fixed at 50% and pH 6. The mixtures were then incubated at 30°C for 11 days. Later, variety conditions of initial moisture content and nitrogen supplementation were introduced and examined on the simvastatin. Further experimental work was carried out using Central Composite Design (CCD) of Response Surface Methodology (RSM), with two factors of initial moisture content and nitrogen source. The results suggested that, among the agricultural products tested; only corn powder was able to produce simvastatin. The optimal condition for simvastatin production on corn was at 50% initial moisture content with supplementation of 0.2% nitrogen source. Malaysian Technical Universities Network (MTUN) 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/11847/1/Development%20of%20Simvastatin%20Production%20by%20Monascus%20Purpureus%20In%20Solid-State%20Fermentation%20Using%20Agricultural%20Product.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/11847/7/fkksa-2015-fmsaid-Development%20of%20Simvastatin.pdf Farhan, Mohd Said (2015) Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product. Journal of Engineering and Technology, 6 (2). pp. 18-28. ISSN 2180-3811 http://journal.utem.edu.my/index.php/jet/article/view/269
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Farhan, Mohd Said Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product
description	Monascuspurpureus is a non-pathogenic fungus that can produce statin called simvastatin, which can lower blood cholesterol level. The objectives of this research were to explore the potential of agricultural product on simvastatin and identify the optimal condition of simvastatin production in solid-state fermentation by Monascuspurpureus FTC 5356. The local agricultural products used were banana, guava, pumpkin, coconut meat, corn and papaya. Initially, the local agricultural products were ground and the initial moisture content of the agricultural products was fixed at 50% and pH 6. The mixtures were then incubated at 30°C for 11 days. Later, variety conditions of initial moisture content and nitrogen supplementation were introduced and examined on the simvastatin. Further experimental work was carried out using Central Composite Design (CCD) of Response Surface Methodology (RSM), with two factors of initial moisture content and nitrogen source. The results suggested that, among the agricultural products tested; only corn powder was able to produce simvastatin. The optimal condition for simvastatin production on corn was at 50% initial moisture content with supplementation of 0.2% nitrogen source.
format	Article
author	Farhan, Mohd Said
author_facet	Farhan, Mohd Said
author_sort	Farhan, Mohd Said
title	Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product
title_short	Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product
title_full	Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product
title_fullStr	Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product
title_full_unstemmed	Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product
title_sort	development of simvastatin production by monascus purpureus in solid-state fermentation using agricultural product
publisher	Malaysian Technical Universities Network (MTUN)
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/11847/ http://umpir.ump.edu.my/id/eprint/11847/ http://umpir.ump.edu.my/id/eprint/11847/1/Development%20of%20Simvastatin%20Production%20by%20Monascus%20Purpureus%20In%20Solid-State%20Fermentation%20Using%20Agricultural%20Product.pdf http://umpir.ump.edu.my/id/eprint/11847/7/fkksa-2015-fmsaid-Development%20of%20Simvastatin.pdf
first_indexed	2023-09-18T22:12:52Z
last_indexed	2023-09-18T22:12:52Z
_version_	1777415143589675008

Development of Simvastatin Production by Monascus Purpureus In Solid-State Fermentation Using Agricultural Product

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