Biochip Development for Biological Cells Manipulation Using DEP
Biochip is a technology platform that has become the medium of researchers in carrying out the analysis of biological cells such as sorting, trapping and screening of biological within a few seconds. To conduct analysis on biological cells, appropriate manipulation techniques are required. In this...
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| Format: | Article |
| Language: | English |
| Published: |
Asian Research Publishing Network (ARPN)
2015
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| Online Access: | http://umpir.ump.edu.my/id/eprint/11295/ http://umpir.ump.edu.my/id/eprint/11295/ http://umpir.ump.edu.my/id/eprint/11295/1/Biochip%20Development%20for%20Biological%20Cells%20Manipulation%20Using%20DEP.pdf |
| Summary: | Biochip is a technology platform that has become the medium of researchers in carrying out the analysis of
biological cells such as sorting, trapping and screening of biological within a few seconds. To conduct analysis on
biological cells, appropriate manipulation techniques are required. In this research, a Dielectrophoresis force (DEP)
manipulation technique was used by applying non-uniform AC electric fields generated by the microeletrodes designed.
For carrying out on one of the main objectives of this study, COMSOL Multiphysics 4.4 software was used in this study in
which the ring planar microarray microelectrodes pattern was designed to investigate the distribution of the electric field
resulting from the microelectrodes designed. Results show the highest electric field strength occurs at the end of the
microelectrode tip at the same time the lowest electric field region can be seen at the microcavity centre. Cell trapping may
also occur in the central part of the micro-cavities with negative dielectrophoresis (nDEP) in which cells will become
interested in the low electric field.
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