Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis

Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost...

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Main Authors:	Fatanah, M. Suhaimi, Chase, J. Geoffrey, Pretty, G. Christopher, Shaw, M. Geoffrey, Normy Norfiza, A. Razak, Ummu Kulthum, Jamaludin
Format:	Article
Language:	English English
Published:	Elsevier Ltd 2015
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/1/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf http://umpir.ump.edu.my/id/eprint/11198/7/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf

id	ump-11198
recordtype	eprints
spelling	ump-111982019-07-17T02:52:42Z http://umpir.ump.edu.my/id/eprint/11198/ Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin TJ Mechanical engineering and machinery Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost impossible to diagnose a patient at the onset of sepsis due to the lack of real-time metrics with high sensitivity and specificity. Patient condition is mostly determined by clinician experience and observation of patient reaction to treatment. In this study, a model-based insulin sensitivity profile is used to identify the relation between individual metabolic conditions to their sepsis status. The hour-to-hour variation of insulin sensitivity is highly independent of the treatment received by the patient and may represent a metabolic status for real-time diagnosis of sepsis. The hour-to-hour variation of insulin sensitivity profile is analyzed with sepsis score calculated according to the definition provided by ACCP/SCCM. P-values of various sepsis score group are computed using Mann-Whitney test. Cumulative distribution function of insulin sensitivity shows separation between different sepsis score and more distinguishable at a higher sepsis score compared to the lower sepsis score. Elsevier Ltd 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/11198/1/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/11198/7/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf Fatanah, M. Suhaimi and Chase, J. Geoffrey and Pretty, G. Christopher and Shaw, M. Geoffrey and Normy Norfiza, A. Razak and Ummu Kulthum, Jamaludin (2015) Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis. IFAC-PapersOnLine, 48 (20). pp. 372-376. ISSN 2405-8963 http://dx.doi.org/10.1016/j.ifacol.2015.10.168 DOI: 10.1016/j.ifacol.2015.10.168
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis
description	Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost impossible to diagnose a patient at the onset of sepsis due to the lack of real-time metrics with high sensitivity and specificity. Patient condition is mostly determined by clinician experience and observation of patient reaction to treatment. In this study, a model-based insulin sensitivity profile is used to identify the relation between individual metabolic conditions to their sepsis status. The hour-to-hour variation of insulin sensitivity is highly independent of the treatment received by the patient and may represent a metabolic status for real-time diagnosis of sepsis. The hour-to-hour variation of insulin sensitivity profile is analyzed with sepsis score calculated according to the definition provided by ACCP/SCCM. P-values of various sepsis score group are computed using Mann-Whitney test. Cumulative distribution function of insulin sensitivity shows separation between different sepsis score and more distinguishable at a higher sepsis score compared to the lower sepsis score.
format	Article
author	Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin
author_facet	Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin
author_sort	Fatanah, M. Suhaimi
title	Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis
title_short	Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis
title_full	Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis
title_fullStr	Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis
title_full_unstemmed	Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis
title_sort	insulin sensitivity as a model-based marker for sepsis diagnosis
publisher	Elsevier Ltd
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/1/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf http://umpir.ump.edu.my/id/eprint/11198/7/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf
first_indexed	2023-09-18T22:11:40Z
last_indexed	2023-09-18T22:11:40Z
_version_	1777415068576645120

Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis

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