Solid phase transformation of carbamazepine-fumaric acid cocrystal

The study is about the solid phase transformation of carbamazepine-fumaric acid co-crystal. Pharmaceutical area is the most importance part in human live. In pharmaceutical, the solubility of the active pharmaceutical ingredients (API) is importance physical property to be studied. Co-crystal format...

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Main Author:	Mohamed Asshafie, Mohamed Sharif
Format:	Undergraduates Project Papers
Language:	English
Published:	2013
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/10634/ http://umpir.ump.edu.my/id/eprint/10634/ http://umpir.ump.edu.my/id/eprint/10634/1/FKKSA-DEGREE-MOHAMED%20ASSHAFIE%20BIN%20MOHAMED%20SHARIF.pdf

id	ump-10634
recordtype	eprints
spelling	ump-106342016-06-24T03:21:56Z http://umpir.ump.edu.my/id/eprint/10634/ Solid phase transformation of carbamazepine-fumaric acid cocrystal Mohamed Asshafie, Mohamed Sharif TP Chemical technology The study is about the solid phase transformation of carbamazepine-fumaric acid co-crystal. Pharmaceutical area is the most importance part in human live. In pharmaceutical, the solubility of the active pharmaceutical ingredients (API) is importance physical property to be studied. Co-crystal formation is an example method to improve the solubility of an API. Carbamazepine is an API which has low solubility. In this study carbamazepine and fumaric acid are used to form co-crystal in ethanol as a solvent. The objective of this research is to study the solid phase transformation of carbamazepine-fumaric acid cocrystal. Initially the solubility of the carbamazepine is measured using gravimetric and High Performance Liquid Chromatography (HPLC). Later, the co-crystal transformation study will be proceed via varying the ratio of fumaric acid to carbamazepine using slurry method. Carbamazepine and fumaric acid are characterized using Thermal Gravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR). The result shows the solubility of carbamazepine and fumaric acid increased as temperature increased. The Fourier Transform Infrared Spectroscopy (FTIR) spectrums show the main spectrum frequency (absorption region in cmˉ¹) for carbamazepine and fumaric acid. Thermo Gravimetric Analysis (TGA) analysis showed the total decomposition for carbamazepine is approximately at 250 °C and for the fumaric acid at 260 °C. As the conclusion the solubility of carbamazepine and fumaric acid has been increased as the temperature increased. Due to the time constraints and the technical failure of the equipment (High Performance Liquid Chromatography (HPLC)) during the analysis has resulted the cocrystal transformation study could not be completed. 2013-06 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/10634/1/FKKSA-DEGREE-MOHAMED%20ASSHAFIE%20BIN%20MOHAMED%20SHARIF.pdf Mohamed Asshafie, Mohamed Sharif (2013) Solid phase transformation of carbamazepine-fumaric acid cocrystal. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:83380&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Mohamed Asshafie, Mohamed Sharif Solid phase transformation of carbamazepine-fumaric acid cocrystal
description	The study is about the solid phase transformation of carbamazepine-fumaric acid co-crystal. Pharmaceutical area is the most importance part in human live. In pharmaceutical, the solubility of the active pharmaceutical ingredients (API) is importance physical property to be studied. Co-crystal formation is an example method to improve the solubility of an API. Carbamazepine is an API which has low solubility. In this study carbamazepine and fumaric acid are used to form co-crystal in ethanol as a solvent. The objective of this research is to study the solid phase transformation of carbamazepine-fumaric acid cocrystal. Initially the solubility of the carbamazepine is measured using gravimetric and High Performance Liquid Chromatography (HPLC). Later, the co-crystal transformation study will be proceed via varying the ratio of fumaric acid to carbamazepine using slurry method. Carbamazepine and fumaric acid are characterized using Thermal Gravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR). The result shows the solubility of carbamazepine and fumaric acid increased as temperature increased. The Fourier Transform Infrared Spectroscopy (FTIR) spectrums show the main spectrum frequency (absorption region in cmˉ¹) for carbamazepine and fumaric acid. Thermo Gravimetric Analysis (TGA) analysis showed the total decomposition for carbamazepine is approximately at 250 °C and for the fumaric acid at 260 °C. As the conclusion the solubility of carbamazepine and fumaric acid has been increased as the temperature increased. Due to the time constraints and the technical failure of the equipment (High Performance Liquid Chromatography (HPLC)) during the analysis has resulted the cocrystal transformation study could not be completed.
format	Undergraduates Project Papers
author	Mohamed Asshafie, Mohamed Sharif
author_facet	Mohamed Asshafie, Mohamed Sharif
author_sort	Mohamed Asshafie, Mohamed Sharif
title	Solid phase transformation of carbamazepine-fumaric acid cocrystal
title_short	Solid phase transformation of carbamazepine-fumaric acid cocrystal
title_full	Solid phase transformation of carbamazepine-fumaric acid cocrystal
title_fullStr	Solid phase transformation of carbamazepine-fumaric acid cocrystal
title_full_unstemmed	Solid phase transformation of carbamazepine-fumaric acid cocrystal
title_sort	solid phase transformation of carbamazepine-fumaric acid cocrystal
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/10634/ http://umpir.ump.edu.my/id/eprint/10634/ http://umpir.ump.edu.my/id/eprint/10634/1/FKKSA-DEGREE-MOHAMED%20ASSHAFIE%20BIN%20MOHAMED%20SHARIF.pdf
first_indexed	2023-09-18T22:10:27Z
last_indexed	2023-09-18T22:10:27Z
_version_	1777414992094560256

Solid phase transformation of carbamazepine-fumaric acid cocrystal

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