Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process

A research was conducted to investigate the stirring speed effect on carbamazepine-saccharin co-crystal crystallization. Co-crystals had shown a significant increase as the co-crystal form has a much better property than pure API over the years of its development. The method of screening used for th...

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Main Authors:	Syarifah, Abd Rahim, M. I. E., Azizi
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/10512/ http://umpir.ump.edu.my/id/eprint/10512/1/Stirring%20Speed%20Effect%20On%20Carbamazepine%20Saccharin%20%28CBZ-SAC%29%20Co-Crystal%20Crystallization%20Process.pdf

id	ump-10512
recordtype	eprints
spelling	ump-105122015-11-05T06:58:44Z http://umpir.ump.edu.my/id/eprint/10512/ Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process Syarifah, Abd Rahim M. I. E., Azizi TP Chemical technology A research was conducted to investigate the stirring speed effect on carbamazepine-saccharin co-crystal crystallization. Co-crystals had shown a significant increase as the co-crystal form has a much better property than pure API over the years of its development. The method of screening used for this study is the cooling crystallization method. Nyvlt’s equation involving the maximum temperature difference between the dissolution and crystallization temperature of CBZ-SAC co-crystals with their respective cooling/heating rate was applied for the study of nucleation kinetics. The stirring speeds under study were 200, 250 and 300 rpm along with carbamazepine concentration of 17.96 mg/ml. The heating and cooling rates used were 0.2, 0.4, 0.6 and 0.8˚C/min respectively. The analysis methods used to characterize the solid state co-crystal were Differential Screening Calorimeter (DSC), Powder X-Ray Diffraction (PXRD) and Fourier Transform Infrared (FTIR) spectroscopy. The PXRD analysis has revealed that the product crystal obtained from screening was a co-crystal. From the DSC analysis, the melting point of CBZ-SAC co-crystal was found at 177˚C. The functional groups found in the CBZ-SAC co-crystal formed were hydrogen bond heteromeric associated between CBZ and SAC, assessed using FTIR. The results revealed that as the speed is increased, the meta-stable zone width (MSZW) was found be increased at the speed of 250 rpm but decreased after the speed went up to 300 rpm. The nucleation order and mass nucleation rate constant shows the opposite pattern where it decreased when the stirring speed used increased from 200 rpm to 250 rpm and increased at the speed of 300 rpm. Future studies is recommendable that the stirring speed study should be carried on at the speed of 260 to 290 rpm to investigate the point where the changes occurs. 2015 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/10512/1/Stirring%20Speed%20Effect%20On%20Carbamazepine%20Saccharin%20%28CBZ-SAC%29%20Co-Crystal%20Crystallization%20Process.pdf Syarifah, Abd Rahim and M. I. E., Azizi (2015) Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process. In: The International Conference on Fluids and Chemical Engineering (FLUIDSCHE 2015), 25-27 November 2015 , Langkawi, Kedah. . (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Syarifah, Abd Rahim M. I. E., Azizi Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process
description	A research was conducted to investigate the stirring speed effect on carbamazepine-saccharin co-crystal crystallization. Co-crystals had shown a significant increase as the co-crystal form has a much better property than pure API over the years of its development. The method of screening used for this study is the cooling crystallization method. Nyvlt’s equation involving the maximum temperature difference between the dissolution and crystallization temperature of CBZ-SAC co-crystals with their respective cooling/heating rate was applied for the study of nucleation kinetics. The stirring speeds under study were 200, 250 and 300 rpm along with carbamazepine concentration of 17.96 mg/ml. The heating and cooling rates used were 0.2, 0.4, 0.6 and 0.8˚C/min respectively. The analysis methods used to characterize the solid state co-crystal were Differential Screening Calorimeter (DSC), Powder X-Ray Diffraction (PXRD) and Fourier Transform Infrared (FTIR) spectroscopy. The PXRD analysis has revealed that the product crystal obtained from screening was a co-crystal. From the DSC analysis, the melting point of CBZ-SAC co-crystal was found at 177˚C. The functional groups found in the CBZ-SAC co-crystal formed were hydrogen bond heteromeric associated between CBZ and SAC, assessed using FTIR. The results revealed that as the speed is increased, the meta-stable zone width (MSZW) was found be increased at the speed of 250 rpm but decreased after the speed went up to 300 rpm. The nucleation order and mass nucleation rate constant shows the opposite pattern where it decreased when the stirring speed used increased from 200 rpm to 250 rpm and increased at the speed of 300 rpm. Future studies is recommendable that the stirring speed study should be carried on at the speed of 260 to 290 rpm to investigate the point where the changes occurs.
format	Conference or Workshop Item
author	Syarifah, Abd Rahim M. I. E., Azizi
author_facet	Syarifah, Abd Rahim M. I. E., Azizi
author_sort	Syarifah, Abd Rahim
title	Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process
title_short	Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process
title_full	Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process
title_fullStr	Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process
title_full_unstemmed	Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process
title_sort	stirring speed effect on carbamazepine saccharin (cbz-sac) co-crystal crystallization process
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/10512/ http://umpir.ump.edu.my/id/eprint/10512/1/Stirring%20Speed%20Effect%20On%20Carbamazepine%20Saccharin%20%28CBZ-SAC%29%20Co-Crystal%20Crystallization%20Process.pdf
first_indexed	2023-09-18T22:10:12Z
last_indexed	2023-09-18T22:10:12Z
_version_	1777414976206536704

Stirring Speed Effect On Carbamazepine Saccharin (CBZ-SAC) Co-Crystal Crystallization Process

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