Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress

UKMR-1, a local variant of mutant Roselle strain (Hibiscus sabdariffa) is enriched with free radical scavenging polyphenols such as anthocyanin, vitamin C and hydroxycitric acid. However, pharmacological actions of UKMR-1 are not fully known. This study was conducted to determine whether supplementa...

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Main Authors:	Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng, Si, Yiang-Lislivia Nee, Satirah Zainalabidin
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/9988/ http://journalarticle.ukm.my/9988/ http://journalarticle.ukm.my/9988/1/16%20Anand%20Ramalingam.pdf

id	ukm-9988
recordtype	eprints
spelling	ukm-99882017-01-20T01:08:17Z http://journalarticle.ukm.my/9988/ Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin, UKMR-1, a local variant of mutant Roselle strain (Hibiscus sabdariffa) is enriched with free radical scavenging polyphenols such as anthocyanin, vitamin C and hydroxycitric acid. However, pharmacological actions of UKMR-1 are not fully known. This study was conducted to determine whether supplementation of aqueous UKMR-1 calyx extract was able to protect against nicotine-induced cardiac injury in rats. In this experimental study, healthy male albino rats were randomly allotted into three groups (n=7 per group): control, nicotine and UKMR-1+Nicotine groups. Nicotine (0.6 mg/kg, i.p.) was administered to both nicotine and UKMR-1+Nicotine groups for 28 consecutive days. UKMR-1+Nicotine group also received 100 mg/kg UKMR-1 extract orally via gavage 30 min prior to nicotine injection, daily. UKMR-1+Nicotine group had significantly (p<0.05) higher lactate dehydrogenase (LDH) activity, as well as lower malondialdehyde content in heart tissue homogenate than nicotine group, suggesting its cardio protective activity by inhibition of lipid peroxidation. UKMR-1 also lowered (p<0.05) the blood pressure in nicotine-administered rats. In addition, UKMR-1 significantly (p<0.05) restored activities of cytosolic superoxide dismutase, glutathione peroxidase and glutathione-S-transferase as well as redox balance ratio (GSH:GSSG). In conclusion, UKMR-1 was able to protect against myocardial injury in rat model of nicotine administration possibly by inhibiting oxidative stress. Penerbit Universiti Kebangsaan Malaysia 2016-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9988/1/16%20Anand%20Ramalingam.pdf Anand Ramalingam, and Siti Balkis Budin, and Lim, Yi-Cheng and Si, Yiang-Lislivia Nee and Satirah Zainalabidin, (2016) Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress. Sains Malaysiana, 45 (7). pp. 1131-1137. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol45num7_2016/contentsVol45num7_2016.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	UKMR-1, a local variant of mutant Roselle strain (Hibiscus sabdariffa) is enriched with free radical scavenging polyphenols such as anthocyanin, vitamin C and hydroxycitric acid. However, pharmacological actions of UKMR-1 are not fully known. This study was conducted to determine whether supplementation of aqueous UKMR-1 calyx extract was able to protect against nicotine-induced cardiac injury in rats. In this experimental study, healthy male albino rats were randomly allotted into three groups (n=7 per group): control, nicotine and UKMR-1+Nicotine groups. Nicotine (0.6 mg/kg, i.p.) was administered to both nicotine and UKMR-1+Nicotine groups for 28 consecutive days. UKMR-1+Nicotine group also received 100 mg/kg UKMR-1 extract orally via gavage 30 min prior to nicotine injection, daily. UKMR-1+Nicotine group had significantly (p<0.05) higher lactate dehydrogenase (LDH) activity, as well as lower malondialdehyde content in heart tissue homogenate than nicotine group, suggesting its cardio protective activity by inhibition of lipid peroxidation. UKMR-1 also lowered (p<0.05) the blood pressure in nicotine-administered rats. In addition, UKMR-1 significantly (p<0.05) restored activities of cytosolic superoxide dismutase, glutathione peroxidase and glutathione-S-transferase as well as redox balance ratio (GSH:GSSG). In conclusion, UKMR-1 was able to protect against myocardial injury in rat model of nicotine administration possibly by inhibiting oxidative stress.
format	Article
author	Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin,
spellingShingle	Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin, Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
author_facet	Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin,
author_sort	Anand Ramalingam,
title	Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
title_short	Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
title_full	Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
title_fullStr	Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
title_full_unstemmed	Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
title_sort	dietary ukmr-1 roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/9988/ http://journalarticle.ukm.my/9988/ http://journalarticle.ukm.my/9988/1/16%20Anand%20Ramalingam.pdf
first_indexed	2023-09-18T19:56:18Z
last_indexed	2023-09-18T19:56:18Z
_version_	1777406551663837184

Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress

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