The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats

In this study, the effects of palm vitamin E (PV) supplementation on glycemic control and lipid profile in diabetic-induce Sprague-Dawley rats have been evaluated. Diabetes in the rats was induced by a single intravenous streptozotocin (50 mg/kg body weight). The diabetic rats were divided into two...

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Main Authors:	Siti Balkis Budin, Abdul Gapor Mohd Top, Wan Nzaimoon Wan Mohamud, Mokhtar Abu Bakar, Khairul Osman, Monica Yau Swee Eng, Jamaludin Mohamed
Format:	Article
Language:	English
Published:	penerbit ukm 2005
Online Access:	http://journalarticle.ukm.my/981/ http://journalarticle.ukm.my/981/ http://journalarticle.ukm.my/981/1/jurnal34.pdf

id	ukm-981
recordtype	eprints
spelling	ukm-9812016-12-14T06:28:29Z http://journalarticle.ukm.my/981/ The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats Siti Balkis Budin, Abdul Gapor Mohd Top, Wan Nzaimoon Wan Mohamud, Mokhtar Abu Bakar, Khairul Osman, Monica Yau Swee Eng, Jamaludin Mohamed, In this study, the effects of palm vitamin E (PV) supplementation on glycemic control and lipid profile in diabetic-induce Sprague-Dawley rats have been evaluated. Diabetes in the rats was induced by a single intravenous streptozotocin (50 mg/kg body weight). The diabetic rats were divided into two groups; supplemented with 200 mg/kg body weight/day of PV and non-supplemented with PV (No PV group). Non-diabetic rats (NDM) formed the control group and only received saline injection. After eight weeks of daily supplementation, PV significantly lowered the fasting blood glucose (FBG) and glycosylated haemoglobin (HbA1c) levels (p<0.01) as compared with No PV group.However, these levels were still significantly higher than the control group (p<0.001). PVsupplementation group also showed significantly lower levels of plasma total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (p<0.001) and higher level of highdensity lipoprotein cholesterol (HDL-C) (p<0.001) as compared with No PV group. In conclusion, this study suggested that PV may be effective in controlling glycemic status and improving dyslipidemia in streptozotocin-induced diabetic rats and has the potential in reducing cardiovascular complication due to diabetes mellitus. penerbit ukm 2005 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/981/1/jurnal34.pdf Siti Balkis Budin, and Abdul Gapor Mohd Top, and Wan Nzaimoon Wan Mohamud, and Mokhtar Abu Bakar, and Khairul Osman, and Monica Yau Swee Eng, and Jamaludin Mohamed, (2005) The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats. Jurnal Sains Kesihatan Malaysia, 3 (1). pp. 1-12. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	In this study, the effects of palm vitamin E (PV) supplementation on glycemic control and lipid profile in diabetic-induce Sprague-Dawley rats have been evaluated. Diabetes in the rats was induced by a single intravenous streptozotocin (50 mg/kg body weight). The diabetic rats were divided into two groups; supplemented with 200 mg/kg body weight/day of PV and non-supplemented with PV (No PV group). Non-diabetic rats (NDM) formed the control group and only received saline injection. After eight weeks of daily supplementation, PV significantly lowered the fasting blood glucose (FBG) and glycosylated haemoglobin (HbA1c) levels (p<0.01) as compared with No PV group.However, these levels were still significantly higher than the control group (p<0.001). PVsupplementation group also showed significantly lower levels of plasma total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (p<0.001) and higher level of highdensity lipoprotein cholesterol (HDL-C) (p<0.001) as compared with No PV group. In conclusion, this study suggested that PV may be effective in controlling glycemic status and improving dyslipidemia in streptozotocin-induced diabetic rats and has the potential in reducing cardiovascular complication due to diabetes mellitus.
format	Article
author	Siti Balkis Budin, Abdul Gapor Mohd Top, Wan Nzaimoon Wan Mohamud, Mokhtar Abu Bakar, Khairul Osman, Monica Yau Swee Eng, Jamaludin Mohamed,
spellingShingle	Siti Balkis Budin, Abdul Gapor Mohd Top, Wan Nzaimoon Wan Mohamud, Mokhtar Abu Bakar, Khairul Osman, Monica Yau Swee Eng, Jamaludin Mohamed, The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats
author_facet	Siti Balkis Budin, Abdul Gapor Mohd Top, Wan Nzaimoon Wan Mohamud, Mokhtar Abu Bakar, Khairul Osman, Monica Yau Swee Eng, Jamaludin Mohamed,
author_sort	Siti Balkis Budin,
title	The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats
title_short	The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats
title_full	The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats
title_fullStr	The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats
title_full_unstemmed	The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats
title_sort	effects of palm vitamin e supplementation on glycemic control and lipid profile in streptozotocin-induced diabetic rats
publisher	penerbit ukm
publishDate	2005
url	http://journalarticle.ukm.my/981/ http://journalarticle.ukm.my/981/ http://journalarticle.ukm.my/981/1/jurnal34.pdf
first_indexed	2023-09-18T19:32:03Z
last_indexed	2023-09-18T19:32:03Z
_version_	1777405026472296448

The effects of palm vitamin E supplementation on Glycemic Control and Lipid Profile in Streptozotocin-Induced Diabetic Rats

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