Evaluation of antioxidant properties, cytotoxicity and acute oral toxicity of Gynura procumbens (Compositae)
Gynura procumbens which is locally known as ‘Sambung nyawa’ in Malay and ‘Feng Wei Jian’ in Chinese, belongs to the botanical family of Compositae. In this study, antioxidant property of G. procumbens extracts was evaluated using DPPH radical scavenging, metal chelating and β-carotene bleaching as...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Kebangsaan Malaysia
2016
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| Online Access: | http://journalarticle.ukm.my/9677/ http://journalarticle.ukm.my/9677/ http://journalarticle.ukm.my/9677/1/10_Wuen_Yew_Teoh.pdf |
| Summary: | Gynura procumbens which is locally known as ‘Sambung nyawa’ in Malay and ‘Feng Wei Jian’ in Chinese, belongs to
the botanical family of Compositae. In this study, antioxidant property of G. procumbens extracts was evaluated using
DPPH radical scavenging, metal chelating and β-carotene bleaching assays. To the best of our knowledge, this is the first
report that evaluated the cytotoxicity of G. procumbens extracts on human colon cancer cells (HT-29, HCT 116, HCT-15,
SW480, Caco-2) and human normal colon cells (CCD-18Co). The results showed that ethyl acetate extract contained
the highest total phenolic content (172.68 mg of GAEs/g of extract) compared to methanol, hexane and water extracts.
Methanol extract possessed better overall antioxidant activities while ethyl acetate extract demonstrated better cytotoxic
activity. At 24 h treatment, ethyl acetate extract demonstrated selective cytotoxicity against HT-29 and HCT 116 cells with
IC50 values of 35.7 and 42.6 µg/mL, respectively. In addition, methanol extract showed negligible level of toxicity when
administered orally. All the results indicated that G. procumbens may provide benefits in prevention and treatment of cancer. |
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