Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl

Angiogenesis has an important role in the invasion, metastasis and growth of tumors. Increased microvessel density (MVD) has been described in oral squamous cell carcinoma (OSCC) compared to oral dysplasia and normal oral tissue. A morphometric study was designed to evaluate the MVD and to evaluat...

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Main Authors:	Zeng, Zhou Tan, Mohammad Zakir Hossain, MD Shahidul Ahsan, Yew, Choy Chew, Swe, Swe Win, Suan, Phaik Khoo
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/9673/ http://journalarticle.ukm.my/9673/ http://journalarticle.ukm.my/9673/1/06_Zeng_Zhou_Tan.pdf

id	ukm-9673
recordtype	eprints
spelling	ukm-96732016-12-14T06:50:30Z http://journalarticle.ukm.my/9673/ Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl Zeng, Zhou Tan Mohammad Zakir Hossain, MD Shahidul Ahsan, Yew, Choy Chew Swe, Swe Win Suan, Phaik Khoo Angiogenesis has an important role in the invasion, metastasis and growth of tumors. Increased microvessel density (MVD) has been described in oral squamous cell carcinoma (OSCC) compared to oral dysplasia and normal oral tissue. A morphometric study was designed to evaluate the MVD and to evaluate the presence of any association between MVD and keratin pearl in the three histopathological grades of OSCC (as defined in Bryne’s grading system). Forty-five samples of OSCC were graded into well differentiated (WDSCC), moderately differentiated (MDSCC) and poorly-differentiated (PDSCC) oral squamous cell carcinoma. Morphometric analysis showed that MVD was significantly lower in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). The density in MDSCC was significant lower than PDSCC. The keratin pearl count was significantly higher in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). Between MDSCC and PDSCC, the keratin pearl count was significantly higher for MDSCC (p=0.001). Pearson correlation test showed a significant negative correlation between keratin pearl and MVD (r=-0.805, p<0.001). The findings suggested that vascularity in OSCC is associated with its cellular differentiation and also associated with keratin pearl formation. Universiti Kebangsaan Malaysia 2016-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9673/1/06_Zeng_Zhou_Tan.pdf Zeng, Zhou Tan and Mohammad Zakir Hossain, and MD Shahidul Ahsan, and Yew, Choy Chew and Swe, Swe Win and Suan, Phaik Khoo (2016) Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl. Sains Malaysiana, 45 (2). pp. 201-205. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid45bil2_2016/KandunganJilid45Bil2_2016.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Angiogenesis has an important role in the invasion, metastasis and growth of tumors. Increased microvessel density (MVD) has been described in oral squamous cell carcinoma (OSCC) compared to oral dysplasia and normal oral tissue. A morphometric study was designed to evaluate the MVD and to evaluate the presence of any association between MVD and keratin pearl in the three histopathological grades of OSCC (as defined in Bryne’s grading system). Forty-five samples of OSCC were graded into well differentiated (WDSCC), moderately differentiated (MDSCC) and poorly-differentiated (PDSCC) oral squamous cell carcinoma. Morphometric analysis showed that MVD was significantly lower in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). The density in MDSCC was significant lower than PDSCC. The keratin pearl count was significantly higher in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). Between MDSCC and PDSCC, the keratin pearl count was significantly higher for MDSCC (p=0.001). Pearson correlation test showed a significant negative correlation between keratin pearl and MVD (r=-0.805, p<0.001). The findings suggested that vascularity in OSCC is associated with its cellular differentiation and also associated with keratin pearl formation.
format	Article
author	Zeng, Zhou Tan Mohammad Zakir Hossain, MD Shahidul Ahsan, Yew, Choy Chew Swe, Swe Win Suan, Phaik Khoo
spellingShingle	Zeng, Zhou Tan Mohammad Zakir Hossain, MD Shahidul Ahsan, Yew, Choy Chew Swe, Swe Win Suan, Phaik Khoo Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
author_facet	Zeng, Zhou Tan Mohammad Zakir Hossain, MD Shahidul Ahsan, Yew, Choy Chew Swe, Swe Win Suan, Phaik Khoo
author_sort	Zeng, Zhou Tan
title	Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_short	Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_full	Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_fullStr	Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_full_unstemmed	Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_sort	microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
publisher	Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/9673/ http://journalarticle.ukm.my/9673/ http://journalarticle.ukm.my/9673/1/06_Zeng_Zhou_Tan.pdf
first_indexed	2023-09-18T19:55:23Z
last_indexed	2023-09-18T19:55:23Z
_version_	1777406494522736640

Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl

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