Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats

The protective effect of the ethanol extract of the rhizome of Zingiber officinale Roscoe on acute hepatotoxicity induced by paracetamol (1000 mg/kg) was studied in plasma and hepatic tissue samples obtained from male Sprague-Dawley rats. The ethanol extract was given in oral doses of 200 mg/kg and...

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Main Authors:	Norina Abdullah, Nur Zakiah Mohd Saat, Hazlin Abu Hasan, Sitri Balkis Budin, Sazlina Kamaralzaman
Format:	Article
Language:	English
Published:	penerbit ukm 2004
Online Access:	http://journalarticle.ukm.my/962/ http://journalarticle.ukm.my/962/ http://journalarticle.ukm.my/962/1/jurnal18.pdf

id	ukm-962
recordtype	eprints
spelling	ukm-9622016-12-14T06:28:25Z http://journalarticle.ukm.my/962/ Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats Norina Abdullah, Nur Zakiah Mohd Saat, Hazlin Abu Hasan, Sitri Balkis Budin, Sazlina Kamaralzaman, The protective effect of the ethanol extract of the rhizome of Zingiber officinale Roscoe on acute hepatotoxicity induced by paracetamol (1000 mg/kg) was studied in plasma and hepatic tissue samples obtained from male Sprague-Dawley rats. The ethanol extract was given in oral doses of 200 mg/kg and 300 mg/kg to the rats at 0, 4 and 8 hrs after paracetamol was given orally. The plasma and liver of the rats were subjected to biochemical analysis 24 hrs after hepatotoxicity was induced to determine the levels of superoxide dismutase(SOD), malonaldehyde (MDA) and aspartate transaminase (AST). The results were compared to the rats which were given the antidote N-acetylcysteine (NAC) (500 mg/kg) at 0, 4 and 8 hrs after the paracetamol dose. The results showed that at 200 mg/kg the extract reduced the plasma levels of SOD significantly (p < 0.05) while at a higher dose of 300 mg/kg it reduced plasma SOD, hepatic MDA, serum AST and increased the levels of plasma proteins significantly (p < 0.05). In conclusion, the ethanol extract of Z. officinale showed protective effect against paracetamol induced hepatotoxicity at both dose levels and the protective effect was better at the higher dose. penerbit ukm 2004 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/962/1/jurnal18.pdf Norina Abdullah, and Nur Zakiah Mohd Saat, and Hazlin Abu Hasan, and Sitri Balkis Budin, and Sazlina Kamaralzaman, (2004) Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats. Jurnal Sains Kesihatan Malaysia, 2 (2). pp. 85-95. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The protective effect of the ethanol extract of the rhizome of Zingiber officinale Roscoe on acute hepatotoxicity induced by paracetamol (1000 mg/kg) was studied in plasma and hepatic tissue samples obtained from male Sprague-Dawley rats. The ethanol extract was given in oral doses of 200 mg/kg and 300 mg/kg to the rats at 0, 4 and 8 hrs after paracetamol was given orally. The plasma and liver of the rats were subjected to biochemical analysis 24 hrs after hepatotoxicity was induced to determine the levels of superoxide dismutase(SOD), malonaldehyde (MDA) and aspartate transaminase (AST). The results were compared to the rats which were given the antidote N-acetylcysteine (NAC) (500 mg/kg) at 0, 4 and 8 hrs after the paracetamol dose. The results showed that at 200 mg/kg the extract reduced the plasma levels of SOD significantly (p < 0.05) while at a higher dose of 300 mg/kg it reduced plasma SOD, hepatic MDA, serum AST and increased the levels of plasma proteins significantly (p < 0.05). In conclusion, the ethanol extract of Z. officinale showed protective effect against paracetamol induced hepatotoxicity at both dose levels and the protective effect was better at the higher dose.
format	Article
author	Norina Abdullah, Nur Zakiah Mohd Saat, Hazlin Abu Hasan, Sitri Balkis Budin, Sazlina Kamaralzaman,
spellingShingle	Norina Abdullah, Nur Zakiah Mohd Saat, Hazlin Abu Hasan, Sitri Balkis Budin, Sazlina Kamaralzaman, Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats
author_facet	Norina Abdullah, Nur Zakiah Mohd Saat, Hazlin Abu Hasan, Sitri Balkis Budin, Sazlina Kamaralzaman,
author_sort	Norina Abdullah,
title	Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats
title_short	Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats
title_full	Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats
title_fullStr	Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats
title_full_unstemmed	Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats
title_sort	protective effect of the ethanol extract of zingiber officinale roscoe on paracetamol induced hepatotoxicity in rats
publisher	penerbit ukm
publishDate	2004
url	http://journalarticle.ukm.my/962/ http://journalarticle.ukm.my/962/ http://journalarticle.ukm.my/962/1/jurnal18.pdf
first_indexed	2023-09-18T19:32:00Z
last_indexed	2023-09-18T19:32:00Z
_version_	1777405023709298688

Protective effect of the ethanol extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats

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