Liposomes as amphiphilic carriers: encapsulation and stability aspects

The aimed of the present study was to evaluate the liposomal formulation regarding its hydrophobicity. The evaluation studies were done based on the amphiphilic nature of the phospholipid liposomes. This paper highlights the importance of such type of lipid based carriers by encapsulation hydrophobi...

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Main Authors:	Sumaira Naeem, Lik, Voon Kiew, Lip, Yong Chung, Muhammad Aqeel Ashraf, Misni Misran
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/9571/ http://journalarticle.ukm.my/9571/ http://journalarticle.ukm.my/9571/1/09_Sumaira_Naeem.pdf

id	ukm-9571
recordtype	eprints
spelling	ukm-95712016-12-14T06:50:20Z http://journalarticle.ukm.my/9571/ Liposomes as amphiphilic carriers: encapsulation and stability aspects Sumaira Naeem, Lik, Voon Kiew Lip, Yong Chung Muhammad Aqeel Ashraf, Misni Misran, The aimed of the present study was to evaluate the liposomal formulation regarding its hydrophobicity. The evaluation studies were done based on the amphiphilic nature of the phospholipid liposomes. This paper highlights the importance of such type of lipid based carriers by encapsulation hydrophobic and hydrophilic drug models. Crystal violet and Nile red were used to represent hydrophilic and hydrophobic moieties before moving to pharmaceutical implications. The formulated liposomes were compared for their hydrophobicity using percent encapsulation efficiencies. The purpose of this formulation was to mimic the red blood cells. The average particle size of 120±25.1 and zeta potential of -10.2±1.4 were in good agreement with reported characteristics of the red blood cells. Per cent encapsulation efficiency for crystal violet was more obvious with a value of 68.1 as compared to 36.5% for Nile red. The prepared liposomes were quite stable for a period of one month. Our findings reflect the fate of our system more suitable for hydrophilic drugs under the given set of formulation parameters. Universiti Kebangsaan Malaysia 2016-01 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9571/1/09_Sumaira_Naeem.pdf Sumaira Naeem, and Lik, Voon Kiew and Lip, Yong Chung and Muhammad Aqeel Ashraf, and Misni Misran, (2016) Liposomes as amphiphilic carriers: encapsulation and stability aspects. Sains Malaysiana, 45 (1). pp. 71-77. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid45bil1_2016/KandunganJilid45Bil1_2016.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The aimed of the present study was to evaluate the liposomal formulation regarding its hydrophobicity. The evaluation studies were done based on the amphiphilic nature of the phospholipid liposomes. This paper highlights the importance of such type of lipid based carriers by encapsulation hydrophobic and hydrophilic drug models. Crystal violet and Nile red were used to represent hydrophilic and hydrophobic moieties before moving to pharmaceutical implications. The formulated liposomes were compared for their hydrophobicity using percent encapsulation efficiencies. The purpose of this formulation was to mimic the red blood cells. The average particle size of 120±25.1 and zeta potential of -10.2±1.4 were in good agreement with reported characteristics of the red blood cells. Per cent encapsulation efficiency for crystal violet was more obvious with a value of 68.1 as compared to 36.5% for Nile red. The prepared liposomes were quite stable for a period of one month. Our findings reflect the fate of our system more suitable for hydrophilic drugs under the given set of formulation parameters.
format	Article
author	Sumaira Naeem, Lik, Voon Kiew Lip, Yong Chung Muhammad Aqeel Ashraf, Misni Misran,
spellingShingle	Sumaira Naeem, Lik, Voon Kiew Lip, Yong Chung Muhammad Aqeel Ashraf, Misni Misran, Liposomes as amphiphilic carriers: encapsulation and stability aspects
author_facet	Sumaira Naeem, Lik, Voon Kiew Lip, Yong Chung Muhammad Aqeel Ashraf, Misni Misran,
author_sort	Sumaira Naeem,
title	Liposomes as amphiphilic carriers: encapsulation and stability aspects
title_short	Liposomes as amphiphilic carriers: encapsulation and stability aspects
title_full	Liposomes as amphiphilic carriers: encapsulation and stability aspects
title_fullStr	Liposomes as amphiphilic carriers: encapsulation and stability aspects
title_full_unstemmed	Liposomes as amphiphilic carriers: encapsulation and stability aspects
title_sort	liposomes as amphiphilic carriers: encapsulation and stability aspects
publisher	Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/9571/ http://journalarticle.ukm.my/9571/ http://journalarticle.ukm.my/9571/1/09_Sumaira_Naeem.pdf
first_indexed	2023-09-18T19:55:16Z
last_indexed	2023-09-18T19:55:16Z
_version_	1777406486809411584

Liposomes as amphiphilic carriers: encapsulation and stability aspects

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