Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening

This study compares the diagnostic performance of urine and serum multiple biomarkers for early diagnosis of ovarian cancer. The sample population includes 119 benign and 101 ovarian cancer patients. The marker combinations used to compare performance include 16 markers whose concentration values we...

Full description

Bibliographic Details
Main Authors:	Hye, Jeong Song, Ki, Seok Jeong, Jong, Dae Kim, Chan, Young Park, Yu, Seop Kim
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/9487/ http://journalarticle.ukm.my/9487/ http://journalarticle.ukm.my/9487/1/03_Hye-Jeong_Song.pdf

id	ukm-9487
recordtype	eprints
spelling	ukm-94872016-12-14T06:50:05Z http://journalarticle.ukm.my/9487/ Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim This study compares the diagnostic performance of urine and serum multiple biomarkers for early diagnosis of ovarian cancer. The sample population includes 119 benign and 101 ovarian cancer patients. The marker combinations used to compare performance include 16 markers whose concentration values were obtained using the Luminex assay. In order to identify an optimal marker combination that could classify ovarian cancer and benign patients, the area under the curve (AUC) is used to evaluate 2-, 3-, and 4-marker combinations and the classification is performed by using logistic regression. In the case of urine samples, the best AUC values are 87.89% for the 2 protein markers combination, 90.22% for the 3 markers combination, and 92.43% for the 4 marker combination. In contrast, the best AUC values for serum sample are 92.4% for the 2 marker combination, 93.63% for the 3 marker combination and 94.63% for the 4 marker combination. This study confirmed that combining multiple biomarkers could improve diagnostic accuracy. Even though the urine sample shows relatively lower performance than serum, urine could be utilized more widely for its simple usability. Universiti Kebangsaan Malaysia 2015-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9487/1/03_Hye-Jeong_Song.pdf Hye, Jeong Song and Ki, Seok Jeong and Jong, Dae Kim and Chan, Young Park and Yu, Seop Kim (2015) Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening. Sains Malaysiana, 44 (12). pp. 1671-1676. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol44num12_2015/contentsVol44num12_2015.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	This study compares the diagnostic performance of urine and serum multiple biomarkers for early diagnosis of ovarian cancer. The sample population includes 119 benign and 101 ovarian cancer patients. The marker combinations used to compare performance include 16 markers whose concentration values were obtained using the Luminex assay. In order to identify an optimal marker combination that could classify ovarian cancer and benign patients, the area under the curve (AUC) is used to evaluate 2-, 3-, and 4-marker combinations and the classification is performed by using logistic regression. In the case of urine samples, the best AUC values are 87.89% for the 2 protein markers combination, 90.22% for the 3 markers combination, and 92.43% for the 4 marker combination. In contrast, the best AUC values for serum sample are 92.4% for the 2 marker combination, 93.63% for the 3 marker combination and 94.63% for the 4 marker combination. This study confirmed that combining multiple biomarkers could improve diagnostic accuracy. Even though the urine sample shows relatively lower performance than serum, urine could be utilized more widely for its simple usability.
format	Article
author	Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim
spellingShingle	Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
author_facet	Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim
author_sort	Hye, Jeong Song
title	Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
title_short	Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
title_full	Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
title_fullStr	Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
title_full_unstemmed	Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
title_sort	performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
publisher	Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/9487/ http://journalarticle.ukm.my/9487/ http://journalarticle.ukm.my/9487/1/03_Hye-Jeong_Song.pdf
first_indexed	2023-09-18T19:55:02Z
last_indexed	2023-09-18T19:55:02Z
_version_	1777406472022392832

Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening

Similar Items