Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations

Anemia of chronic disease (ACD) frequently occurred in patients with chronic inflammatory diseases and can be treated by treating the underlying disease. On the other hand, iron-deficiency anemia (IDA), the most common type of anemia, occurred with iron loss or when the iron requirement of the body...

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Main Authors:	Eun, Suk Yang, Yu, Seop Kim, Chan, Young Park, Jong, Dae Kim, Hye, Jeong Song
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/9485/ http://journalarticle.ukm.my/9485/ http://journalarticle.ukm.my/9485/1/01_Eun-Suk_Yang.pdf

id	ukm-9485
recordtype	eprints
spelling	ukm-94852016-12-14T06:50:04Z http://journalarticle.ukm.my/9485/ Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations Eun, Suk Yang Yu, Seop Kim Chan, Young Park Jong, Dae Kim Hye, Jeong Song Anemia of chronic disease (ACD) frequently occurred in patients with chronic inflammatory diseases and can be treated by treating the underlying disease. On the other hand, iron-deficiency anemia (IDA), the most common type of anemia, occurred with iron loss or when the iron requirement of the body was increased. Since the treatment methods for ACD and IDA differ, it is important to clinically distinguish between the two types of anemia. In this study, we investigated and evaluated the performance of a number of biomarkers, including ferritin, soluble transferrin receptor (sTfR), hepcidin, C-reactive protein (CRP) and combination markers containing ferritin for the diagnosis of IDA using serum samples from Korean patients (80 ACD and 48 IDA Korean patients). Among the single markers, ferritin exhibited the best performance with 98.58% AUC and 97.50% sensitivity. In this study, a combination of two biomarkers was used to differentially diagnose IDA and ACD. Among the combination markers, ferritin + sTfR showed the best performance with 99.51% AUC and 98.75% sensitivity. We found that the ferritin + sTfR combination showed the best diagnostic performance with 1.25% higher SN than ferritin alone. Moreover, it also showed 10% better diagnostic performance than the single ferritin marker within the data range where the distinction between ACD and IDA is unclear. We propose that using combination markers containing ferritin may diagnose IDA more accurately and facilitate the determination of the appropriate anemia treatment to expedite patient recovery. Universiti Kebangsaan Malaysia 2015-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9485/1/01_Eun-Suk_Yang.pdf Eun, Suk Yang and Yu, Seop Kim and Chan, Young Park and Jong, Dae Kim and Hye, Jeong Song (2015) Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations. Sains Malaysiana, 44 (12). pp. 1653-1659. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol44num12_2015/contentsVol44num12_2015.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Anemia of chronic disease (ACD) frequently occurred in patients with chronic inflammatory diseases and can be treated by treating the underlying disease. On the other hand, iron-deficiency anemia (IDA), the most common type of anemia, occurred with iron loss or when the iron requirement of the body was increased. Since the treatment methods for ACD and IDA differ, it is important to clinically distinguish between the two types of anemia. In this study, we investigated and evaluated the performance of a number of biomarkers, including ferritin, soluble transferrin receptor (sTfR), hepcidin, C-reactive protein (CRP) and combination markers containing ferritin for the diagnosis of IDA using serum samples from Korean patients (80 ACD and 48 IDA Korean patients). Among the single markers, ferritin exhibited the best performance with 98.58% AUC and 97.50% sensitivity. In this study, a combination of two biomarkers was used to differentially diagnose IDA and ACD. Among the combination markers, ferritin + sTfR showed the best performance with 99.51% AUC and 98.75% sensitivity. We found that the ferritin + sTfR combination showed the best diagnostic performance with 1.25% higher SN than ferritin alone. Moreover, it also showed 10% better diagnostic performance than the single ferritin marker within the data range where the distinction between ACD and IDA is unclear. We propose that using combination markers containing ferritin may diagnose IDA more accurately and facilitate the determination of the appropriate anemia treatment to expedite patient recovery.
format	Article
author	Eun, Suk Yang Yu, Seop Kim Chan, Young Park Jong, Dae Kim Hye, Jeong Song
spellingShingle	Eun, Suk Yang Yu, Seop Kim Chan, Young Park Jong, Dae Kim Hye, Jeong Song Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
author_facet	Eun, Suk Yang Yu, Seop Kim Chan, Young Park Jong, Dae Kim Hye, Jeong Song
author_sort	Eun, Suk Yang
title	Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_short	Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_full	Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_fullStr	Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_full_unstemmed	Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_sort	improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
publisher	Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/9485/ http://journalarticle.ukm.my/9485/ http://journalarticle.ukm.my/9485/1/01_Eun-Suk_Yang.pdf
first_indexed	2023-09-18T19:54:59Z
last_indexed	2023-09-18T19:54:59Z
_version_	1777406468842061824

Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations

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