Kesan in vitro rilmenidine ke atas rembesan insulin
This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak...
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| Format: | Article |
| Language: | English |
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penerbit ukm
2003
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| Online Access: | http://journalarticle.ukm.my/948/ http://journalarticle.ukm.my/948/ http://journalarticle.ukm.my/948/1/jurnal4.pdf |
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ukm-948 |
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eprints |
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ukm-9482016-12-14T06:28:23Z http://journalarticle.ukm.my/948/ Kesan in vitro rilmenidine ke atas rembesan insulin Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. penerbit ukm 2003-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/948/1/jurnal4.pdf Rosnani Hashim, and Tariq Abdul Razak, and Suhaimi Hashim, (2003) Kesan in vitro rilmenidine ke atas rembesan insulin. Jurnal Sains Kesihatan Malaysia, 1 . pp. 1-7. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
Universiti Kebangasaan Malaysia |
| building |
UKM Institutional Repository |
| collection |
Online Access |
| language |
English |
| description |
This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. |
| format |
Article |
| author |
Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, |
| spellingShingle |
Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, Kesan in vitro rilmenidine ke atas rembesan insulin |
| author_facet |
Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, |
| author_sort |
Rosnani Hashim, |
| title |
Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_short |
Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_full |
Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_fullStr |
Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_full_unstemmed |
Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_sort |
kesan in vitro rilmenidine ke atas rembesan insulin |
| publisher |
penerbit ukm |
| publishDate |
2003 |
| url |
http://journalarticle.ukm.my/948/ http://journalarticle.ukm.my/948/ http://journalarticle.ukm.my/948/1/jurnal4.pdf |
| first_indexed |
2023-09-18T19:31:58Z |
| last_indexed |
2023-09-18T19:31:58Z |
| _version_ |
1777405021663526912 |