What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma

This was a case of a young lady presenting with 10 year history of a mass in the right eye. It was found to be an adenocarcinoma of the lacrimal gland from histopathological biopsy. She underwent wide excision, orbital exenteration and reconstruction with a free rectus abdominis flap. Unfortunately,...

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Main Authors:	Farrah-Hani Imran, Muthukumaran Guhan, Enda Kelly, Jegan Thanabalan, Farizal Fadzil, Faridah Hanum
Format:	Article
Language:	English
Published:	Faculty of Medicine, UKM Medical Centre 2015
Online Access:	http://journalarticle.ukm.my/9304/ http://journalarticle.ukm.my/9304/ http://journalarticle.ukm.my/9304/1/15-MS0104-Farrah-Hani%2520Imran%2520et%2520al..pdf

id	ukm-9304
recordtype	eprints
spelling	ukm-93042016-12-14T06:49:31Z http://journalarticle.ukm.my/9304/ What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma Farrah-Hani Imran, Muthukumaran Guhan, Enda Kelly, Jegan Thanabalan, Farizal Fadzil, Faridah Hanum, This was a case of a young lady presenting with 10 year history of a mass in the right eye. It was found to be an adenocarcinoma of the lacrimal gland from histopathological biopsy. She underwent wide excision, orbital exenteration and reconstruction with a free rectus abdominis flap. Unfortunately, she had a tumour recurrence which was not controlled by radiotherapy and a second excision. The behavior of the tumour was aggressive, resulting in widespread metastases. She passed away within a year of her presentation. Of note, the histopathology report from the second excision turned out to be sarcomatoid carcinoma. This is described in the literature as dedifferentiation, or high grade transformation (HGT). Occurrence of dedifferentiation in salivary gland tumours is well-established, but not as well-described in lacrimal gland tumours. In this case, there was a severely delayed presentation of a lacrimal gland adenocarcinoma in a young person, which underwent dedifferentiation into a sarcomatoid carcinoma. This phenomena is associated with aggressive tumour biology behavior and poor prognosis, despite surgery and radiotherapy. Faculty of Medicine, UKM Medical Centre 2015-12-14 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9304/1/15-MS0104-Farrah-Hani%2520Imran%2520et%2520al..pdf Farrah-Hani Imran, and Muthukumaran Guhan, and Enda Kelly, and Jegan Thanabalan, and Farizal Fadzil, and Faridah Hanum, (2015) What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma. Journal of Surgical Academia, 5 (2). pp. 66-69. ISSN 2231-7481 http://jsurgical.com
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	This was a case of a young lady presenting with 10 year history of a mass in the right eye. It was found to be an adenocarcinoma of the lacrimal gland from histopathological biopsy. She underwent wide excision, orbital exenteration and reconstruction with a free rectus abdominis flap. Unfortunately, she had a tumour recurrence which was not controlled by radiotherapy and a second excision. The behavior of the tumour was aggressive, resulting in widespread metastases. She passed away within a year of her presentation. Of note, the histopathology report from the second excision turned out to be sarcomatoid carcinoma. This is described in the literature as dedifferentiation, or high grade transformation (HGT). Occurrence of dedifferentiation in salivary gland tumours is well-established, but not as well-described in lacrimal gland tumours. In this case, there was a severely delayed presentation of a lacrimal gland adenocarcinoma in a young person, which underwent dedifferentiation into a sarcomatoid carcinoma. This phenomena is associated with aggressive tumour biology behavior and poor prognosis, despite surgery and radiotherapy.
format	Article
author	Farrah-Hani Imran, Muthukumaran Guhan, Enda Kelly, Jegan Thanabalan, Farizal Fadzil, Faridah Hanum,
spellingShingle	Farrah-Hani Imran, Muthukumaran Guhan, Enda Kelly, Jegan Thanabalan, Farizal Fadzil, Faridah Hanum, What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma
author_facet	Farrah-Hani Imran, Muthukumaran Guhan, Enda Kelly, Jegan Thanabalan, Farizal Fadzil, Faridah Hanum,
author_sort	Farrah-Hani Imran,
title	What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma
title_short	What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma
title_full	What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma
title_fullStr	What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma
title_full_unstemmed	What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma
title_sort	what lurks beneath: lacrimal gland adenocarcinoma dedifferentiation to sarcomatoid carcinoma
publisher	Faculty of Medicine, UKM Medical Centre
publishDate	2015
url	http://journalarticle.ukm.my/9304/ http://journalarticle.ukm.my/9304/ http://journalarticle.ukm.my/9304/1/15-MS0104-Farrah-Hani%2520Imran%2520et%2520al..pdf
first_indexed	2023-09-18T19:54:29Z
last_indexed	2023-09-18T19:54:29Z
_version_	1777406437371150336

What Lurks Beneath: Lacrimal Gland Adenocarcinoma Dedifferentiation to Sarcomatoid Carcinoma

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