Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism

Acinetobacter baumanii is an opportunistic bacterium that causes widespread nosocomial infections and tends to be multi-resistant to most of antibiotics. Tigecycline is a well-known antibiotic that possesses a wide-range of activities and is very active in vitro towards a variety of resistant pathog...

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Main Authors:	Alfizah, H., Siti Sarah, O.Z., Noraziah, M.Z.
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/8992/ http://journalarticle.ukm.my/8992/ http://journalarticle.ukm.my/8992/1/19_H._Alfizah.pdf

id	ukm-8992
recordtype	eprints
spelling	ukm-89922016-12-14T06:48:39Z http://journalarticle.ukm.my/8992/ Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism Alfizah, H. Siti Sarah, O.Z. Noraziah, M.Z. Acinetobacter baumanii is an opportunistic bacterium that causes widespread nosocomial infections and tends to be multi-resistant to most of antibiotics. Tigecycline is a well-known antibiotic that possesses a wide-range of activities and is very active in vitro towards a variety of resistant pathogens, including A. baumanii. The aim of this study was to evaluate the effects of the imipenem and tigecycline combination against carbapenem-resistant A. baumanii (CRAB). The minimal inhibitory concentration (MIC) was determined using the E-test method. The microbroth checkerboard technique was employed to determine the effects of the imipenem and tigecycline interaction by obtaining the fractional inhibitory concentration (FIC) index value. A time kill (TK) study was performed to identify any synergistic effects when both imipenem and tigecycline were used against CRAB strains. The result demonstrated that all A. baumanni strains exhibited imipenem MIC values of 32 μg/mL. The combination of imipenem and tigecycline demonstrated an additive effect (FIC > 0.5-4) against all of the strains and synergistic activity (decrement of > 2 log10 CFU/mL) towards AC 34/07 and AC 32/06 strains. The use of imipenem in combination with tigecycline resulted in a more efficient activity and an increased capability to control CRAB infections. This effect showed potential combination and may be of importance in the development or modification of antimicrobial agents for the treatment of CRAB infections. Universiti Kebangsaan Malaysia 2015-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8992/1/19_H._Alfizah.pdf Alfizah, H. and Siti Sarah, O.Z. and Noraziah, M.Z. (2015) Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism. Sains Malaysiana, 44 (7). pp. 1061-1065. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid44bil7_2015/KandunganJilid44Bil7_2015.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Acinetobacter baumanii is an opportunistic bacterium that causes widespread nosocomial infections and tends to be multi-resistant to most of antibiotics. Tigecycline is a well-known antibiotic that possesses a wide-range of activities and is very active in vitro towards a variety of resistant pathogens, including A. baumanii. The aim of this study was to evaluate the effects of the imipenem and tigecycline combination against carbapenem-resistant A. baumanii (CRAB). The minimal inhibitory concentration (MIC) was determined using the E-test method. The microbroth checkerboard technique was employed to determine the effects of the imipenem and tigecycline interaction by obtaining the fractional inhibitory concentration (FIC) index value. A time kill (TK) study was performed to identify any synergistic effects when both imipenem and tigecycline were used against CRAB strains. The result demonstrated that all A. baumanni strains exhibited imipenem MIC values of 32 μg/mL. The combination of imipenem and tigecycline demonstrated an additive effect (FIC > 0.5-4) against all of the strains and synergistic activity (decrement of > 2 log10 CFU/mL) towards AC 34/07 and AC 32/06 strains. The use of imipenem in combination with tigecycline resulted in a more efficient activity and an increased capability to control CRAB infections. This effect showed potential combination and may be of importance in the development or modification of antimicrobial agents for the treatment of CRAB infections.
format	Article
author	Alfizah, H. Siti Sarah, O.Z. Noraziah, M.Z.
spellingShingle	Alfizah, H. Siti Sarah, O.Z. Noraziah, M.Z. Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism
author_facet	Alfizah, H. Siti Sarah, O.Z. Noraziah, M.Z.
author_sort	Alfizah, H.
title	Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism
title_short	Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism
title_full	Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism
title_fullStr	Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism
title_full_unstemmed	Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism
title_sort	interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism
publisher	Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/8992/ http://journalarticle.ukm.my/8992/ http://journalarticle.ukm.my/8992/1/19_H._Alfizah.pdf
first_indexed	2023-09-18T19:53:42Z
last_indexed	2023-09-18T19:53:42Z
_version_	1777406389011873792

Interaction of imipenem and tigecycline against carbapenem-resistant acinetobacter baumanii: the relativity of synergism

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