Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol

Background: Various experimental, epidemiological, and clinical studies have shown that hyperuricemia is associated with development of hypertension, visceral obesity, insulin resistance, dyslipidemia, type 2 diabetes, kidney diseases, and cardiovascular and cerebrovascular events. Whether hyperur...

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Main Authors:	Chetan R. Acharya, Abhinav K. Sharma, ND Kantharia
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/8764/ http://journalarticle.ukm.my/8764/ http://journalarticle.ukm.my/8764/1/P.168-172.pdf

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spelling	ukm-87642016-12-14T06:48:05Z http://journalarticle.ukm.my/8764/ Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol Chetan R. Acharya, Abhinav K. Sharma, ND Kantharia, Background: Various experimental, epidemiological, and clinical studies have shown that hyperuricemia is associated with development of hypertension, visceral obesity, insulin resistance, dyslipidemia, type 2 diabetes, kidney diseases, and cardiovascular and cerebrovascular events. Whether hyperuricemia is a cause or effect is a debatable subject. Although the pathogenesis of these diseases is complex and incompletely understood, it is clear that oxidative stress and damage to proteins and lipids is common for all of them. Objective: To determine whether hyperuricemia causes oxidative stress in patients with gout, and to evaluate the effect of allopurinol treatment on oxidative stress after 1 and 3 months in these patients. Materials and Methods: Patients with newly diagnosed gout (n = 30) and healthy age- and sex-matched volunteers (n = 30) were enrolled in the study. They were treated with 100-mg allopurinol 8 hourly in a day for 3 months. Serum uric acid levels and levels of oxidative stress such as serum malondialdehyde (MDA), erythrocyte catalase (CAT), and erythrocyte superoxide dismutase (SOD) were measured before treatment, and after 1 and 3 months of treatment. Pretreatment levels of all the parameters were compared in both the groups using unpaired t-test. The parameters were also analyzed in test group at 0, 1, and 3 months of treatment using repeated-measures analysis of variance test. Results: Pretreatment levels of serum uric acid and MDA were significantly higher in patients as compared to control group (P o 0.01). They were significantly reduced after 1 (P o 0.05) and 3 months (P o 0.01) of treatment with allopurinol. Pretreatment levels of CAT and SOD were significantly lower in patients as compared to control group (P o 0.01); they were increased significantly after 1 (P o 0.01) and 3 months (P o 0.01) of treatment with allopurinol. Conclusion: From this study, it can be suggested that hyperuricemia causes oxidative stress in patients with gout. Besides the main benefit of lowering serum uric acid level, allopurinol also decreases oxidative stress in patients with gout. Universiti Kebangsaan Malaysia 2015-06-17 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8764/1/P.168-172.pdf Chetan R. Acharya, and Abhinav K. Sharma, and ND Kantharia, (2015) Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol. International Journal of Public Health Research, 4 (2). pp. 168-172. ISSN 2232-0245 www.ijphr.ukm.my
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Background: Various experimental, epidemiological, and clinical studies have shown that hyperuricemia is associated with development of hypertension, visceral obesity, insulin resistance, dyslipidemia, type 2 diabetes, kidney diseases, and cardiovascular and cerebrovascular events. Whether hyperuricemia is a cause or effect is a debatable subject. Although the pathogenesis of these diseases is complex and incompletely understood, it is clear that oxidative stress and damage to proteins and lipids is common for all of them. Objective: To determine whether hyperuricemia causes oxidative stress in patients with gout, and to evaluate the effect of allopurinol treatment on oxidative stress after 1 and 3 months in these patients. Materials and Methods: Patients with newly diagnosed gout (n = 30) and healthy age- and sex-matched volunteers (n = 30) were enrolled in the study. They were treated with 100-mg allopurinol 8 hourly in a day for 3 months. Serum uric acid levels and levels of oxidative stress such as serum malondialdehyde (MDA), erythrocyte catalase (CAT), and erythrocyte superoxide dismutase (SOD) were measured before treatment, and after 1 and 3 months of treatment. Pretreatment levels of all the parameters were compared in both the groups using unpaired t-test. The parameters were also analyzed in test group at 0, 1, and 3 months of treatment using repeated-measures analysis of variance test. Results: Pretreatment levels of serum uric acid and MDA were significantly higher in patients as compared to control group (P o 0.01). They were significantly reduced after 1 (P o 0.05) and 3 months (P o 0.01) of treatment with allopurinol. Pretreatment levels of CAT and SOD were significantly lower in patients as compared to control group (P o 0.01); they were increased significantly after 1 (P o 0.01) and 3 months (P o 0.01) of treatment with allopurinol. Conclusion: From this study, it can be suggested that hyperuricemia causes oxidative stress in patients with gout. Besides the main benefit of lowering serum uric acid level, allopurinol also decreases oxidative stress in patients with gout.
format	Article
author	Chetan R. Acharya, Abhinav K. Sharma, ND Kantharia,
spellingShingle	Chetan R. Acharya, Abhinav K. Sharma, ND Kantharia, Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol
author_facet	Chetan R. Acharya, Abhinav K. Sharma, ND Kantharia,
author_sort	Chetan R. Acharya,
title	Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol
title_short	Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol
title_full	Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol
title_fullStr	Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol
title_full_unstemmed	Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol
title_sort	involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol
publisher	Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/8764/ http://journalarticle.ukm.my/8764/ http://journalarticle.ukm.my/8764/1/P.168-172.pdf
first_indexed	2023-09-18T19:53:09Z
last_indexed	2023-09-18T19:53:09Z
_version_	1777406353864654848

Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol

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