Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study

Background: The etiologies of thrombocytopenia are diverse. Various studies on thrombocytopenia are done in the past have related to specific etiologies. Objectives: This study attempts to determine the common etiologies of thrombocytopenia in adult patients admitted to Civil Hospital, Ahmedabad....

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Main Authors:	Shruti K Bhalara, Smita Shah, Hansa Goswami, RN Gonsai
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/8729/ http://journalarticle.ukm.my/8729/ http://journalarticle.ukm.my/8729/1/P.7-10.pdf

id	ukm-8729
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spelling	ukm-87292016-12-14T06:48:01Z http://journalarticle.ukm.my/8729/ Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study Shruti K Bhalara, Smita Shah, Hansa Goswami, RN Gonsai, Background: The etiologies of thrombocytopenia are diverse. Various studies on thrombocytopenia are done in the past have related to specific etiologies. Objectives: This study attempts to determine the common etiologies of thrombocytopenia in adult patients admitted to Civil Hospital, Ahmedabad. Material and Methods: A cross-sectional study was carried out at Civil Hospital, Ahmedabad. Patients with thrombocytopenia more than 18 years of age at admission between 1 October and 31 October 2013 were followed up during their stay in hospital, diagnosis were made, and bleeding manifestations and requirement of platelet transfusion were recorded. Results: From the 412 patients studied, dengue was diagnosed in 28.6% of patients followed by malaria in 22.8%, chronic liver disease in 15.2%, hypersplenism in 12.3%, septicemia in 6.3%, gestational thrombocytopenia and disseminated intravascular coagulation in 5.5%, immune thrombocytopenic purpura (ITP) in 3.1%, megaloblastic anemia in 1.9%, human immunodeficiency virus in 1.4%, drug-induced thrombocytopenia in 1.2%, leukemia in 0.7%, and aplastic anemia in 0.48%. Bleeding secondary to thrombocytopenia was seen in 46 (11.2%) patients; of them, 28 were diagnosed with dengue fever, 4 with chronic liver disease, 3 with sepsis, 2 with hematological malignancies, and 9 with ITP. The common bleeding manifestations were gum bleed, purpura, petechial rash, and bruising. All the cases with platelet count o5,000/mL had bleeding manifestations secondary to thrombocytopenia. From the patients studied, 79.3% had fever associated with thrombocytopenia. Platelet transfusion was given to 87 patients: of these, 46 (52.8%) were transfused because of bleeding and 41 (47.1%) were given prophylactic transfusion. Conclusion: Dengue fever was the most common cause of thrombocytopenia and the most common etiology found in patients who had bleeding secondary to thrombocytopenia with gum bleed as a common manifestation. There was no definitive trigger value of platelet for platelet transfusion, and transfusion because of bleeding and prophylactic transfusion were given in almost similar proportions of patients. Universiti Kebangsaan Malaysia 2015-06-17 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8729/1/P.7-10.pdf Shruti K Bhalara, and Smita Shah, and Hansa Goswami, and RN Gonsai, (2015) Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study. International Journal of Public Health Research, 4 (1). pp. 7-10. ISSN 2232-0245 www.ijphr.ukm.my
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Background: The etiologies of thrombocytopenia are diverse. Various studies on thrombocytopenia are done in the past have related to specific etiologies. Objectives: This study attempts to determine the common etiologies of thrombocytopenia in adult patients admitted to Civil Hospital, Ahmedabad. Material and Methods: A cross-sectional study was carried out at Civil Hospital, Ahmedabad. Patients with thrombocytopenia more than 18 years of age at admission between 1 October and 31 October 2013 were followed up during their stay in hospital, diagnosis were made, and bleeding manifestations and requirement of platelet transfusion were recorded. Results: From the 412 patients studied, dengue was diagnosed in 28.6% of patients followed by malaria in 22.8%, chronic liver disease in 15.2%, hypersplenism in 12.3%, septicemia in 6.3%, gestational thrombocytopenia and disseminated intravascular coagulation in 5.5%, immune thrombocytopenic purpura (ITP) in 3.1%, megaloblastic anemia in 1.9%, human immunodeficiency virus in 1.4%, drug-induced thrombocytopenia in 1.2%, leukemia in 0.7%, and aplastic anemia in 0.48%. Bleeding secondary to thrombocytopenia was seen in 46 (11.2%) patients; of them, 28 were diagnosed with dengue fever, 4 with chronic liver disease, 3 with sepsis, 2 with hematological malignancies, and 9 with ITP. The common bleeding manifestations were gum bleed, purpura, petechial rash, and bruising. All the cases with platelet count o5,000/mL had bleeding manifestations secondary to thrombocytopenia. From the patients studied, 79.3% had fever associated with thrombocytopenia. Platelet transfusion was given to 87 patients: of these, 46 (52.8%) were transfused because of bleeding and 41 (47.1%) were given prophylactic transfusion. Conclusion: Dengue fever was the most common cause of thrombocytopenia and the most common etiology found in patients who had bleeding secondary to thrombocytopenia with gum bleed as a common manifestation. There was no definitive trigger value of platelet for platelet transfusion, and transfusion because of bleeding and prophylactic transfusion were given in almost similar proportions of patients.
format	Article
author	Shruti K Bhalara, Smita Shah, Hansa Goswami, RN Gonsai,
spellingShingle	Shruti K Bhalara, Smita Shah, Hansa Goswami, RN Gonsai, Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study
author_facet	Shruti K Bhalara, Smita Shah, Hansa Goswami, RN Gonsai,
author_sort	Shruti K Bhalara,
title	Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study
title_short	Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study
title_full	Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study
title_fullStr	Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study
title_full_unstemmed	Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study
title_sort	clinical and etiological profile of thrombocytopenia in adults: a tertiary-care hospital-based cross-sectional study
publisher	Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/8729/ http://journalarticle.ukm.my/8729/ http://journalarticle.ukm.my/8729/1/P.7-10.pdf
first_indexed	2023-09-18T19:53:06Z
last_indexed	2023-09-18T19:53:06Z
_version_	1777406350503968768

Clinical and etiological profile of thrombocytopenia in adults: A tertiary-care hospital-based cross-sectional study

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