In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones

Glaciozyma antarctica is a psychrophilic yeast isolated from the Antarctic sea ice. In this study, we performed a de novo characterisation of molecular chaperones from G. antarctica genome datasets. A total of 7857 genes that code for various types of proteins have been predicted from the G. antar...

Full description

Bibliographic Details
Main Authors:	Nur Athirah, Y., Abu Bakar, F.D., Illias, R.M., Mahadi, N.M., Murad, A.M.A.
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/8724/ http://journalarticle.ukm.my/8724/ http://journalarticle.ukm.my/8724/1/44_1_26.pdf

id	ukm-8724
recordtype	eprints
spelling	ukm-87242016-12-14T06:48:00Z http://journalarticle.ukm.my/8724/ In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A. Glaciozyma antarctica is a psychrophilic yeast isolated from the Antarctic sea ice. In this study, we performed a de novo characterisation of molecular chaperones from G. antarctica genome datasets. A total of 7857 genes that code for various types of proteins have been predicted from the G. antarctica genome sequence. From these genes, we identified 89 possible molecular chaperones that matched known molecular chaperones from other organisms available in various databases such as Uniprot, Gene Ontology, cpnDB and NCBI. For an in-depth analysis of molecular functions, we used homologous clustering to transfer knowledge from unknown to known functions using Cluster Analysis of Sequences (CLANS) bioinformatics software. The results reveal 12 major groups of chaperones that contribute to the cold-adaptation mechanism through their molecular function, biological processes and cellular components. The findings lay the foundation for future functional genomics studies on this organism and shed light on how lower eukaryotic cells respond to low temperature. Penerbit Universiti Kebangsaan Malaysia 2015-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8724/1/44_1_26.pdf Nur Athirah, Y. and Abu Bakar, F.D. and Illias, R.M. and Mahadi, N.M. and Murad, A.M.A. (2015) In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones. Malaysian Applied Biology, 44 (1). pp. 161-165. ISSN 0126-8643 http://www.mabjournal.com/index.php?option=com_content&view=article&id=505&catid=59:current-view&Itemid=56
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Glaciozyma antarctica is a psychrophilic yeast isolated from the Antarctic sea ice. In this study, we performed a de novo characterisation of molecular chaperones from G. antarctica genome datasets. A total of 7857 genes that code for various types of proteins have been predicted from the G. antarctica genome sequence. From these genes, we identified 89 possible molecular chaperones that matched known molecular chaperones from other organisms available in various databases such as Uniprot, Gene Ontology, cpnDB and NCBI. For an in-depth analysis of molecular functions, we used homologous clustering to transfer knowledge from unknown to known functions using Cluster Analysis of Sequences (CLANS) bioinformatics software. The results reveal 12 major groups of chaperones that contribute to the cold-adaptation mechanism through their molecular function, biological processes and cellular components. The findings lay the foundation for future functional genomics studies on this organism and shed light on how lower eukaryotic cells respond to low temperature.
format	Article
author	Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A.
spellingShingle	Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A. In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
author_facet	Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A.
author_sort	Nur Athirah, Y.
title	In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
title_short	In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
title_full	In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
title_fullStr	In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
title_full_unstemmed	In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
title_sort	in silico characterisation of the glaciozyma antarctica genome: mining the molecular chaperones
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/8724/ http://journalarticle.ukm.my/8724/ http://journalarticle.ukm.my/8724/1/44_1_26.pdf
first_indexed	2023-09-18T19:53:05Z
last_indexed	2023-09-18T19:53:05Z
_version_	1777406349897891840

In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones

Similar Items