Enhancement of fertility and libido in male sprague dawley rats following the administration of aqueous extract of Lunasia amara
Lunasia amara (sanrego) is a folk medicinal herb which has been consumed to treat male fertility and libido. This study aims to investigate the effect of L. amara aqueous extract on libido, sperm quality, serum testosterone level, antioxidant enzyme activity and histology of testis. Two groups (n=...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2015
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| Online Access: | http://journalarticle.ukm.my/8719/ http://journalarticle.ukm.my/8719/ http://journalarticle.ukm.my/8719/1/44_1_21.pdf |
| Summary: | Lunasia amara (sanrego) is a folk medicinal herb which has been consumed to treat male fertility and libido. This study
aims to investigate the effect of L. amara aqueous extract on libido, sperm quality, serum testosterone level, antioxidant
enzyme activity and histology of testis. Two groups (n=6) were given distilled water (control) and aqueous extract of L.
amara at a dose of 60 mg/kg/body weight respectively daily for 42 days. On day 43, rats were subjected to sexual behavioural
test before sacrificed for sperm quality and testosterone analysis. Cauda epididymis was isolated for sperm quality analysis
whereas serum was collected to determine the level of testosterone. Histology of testes and antioxidant enzyme activities
were also investigated. Results showed the administration of L. amara aqueous extract significantly (p<0.05) increased the
mount frequency compared to normal rats. Sperm count, motility, viability, testosterone level and testicular antioxidant enzyme
activities in treated rats showed significantly (p < 0.05) increased compared to control. Section of seminiferous tubules in
treated group showed the increasing of spermatozoa density compared to the normal group. In conclusion, L. amara aqueous
extract is effective in improving libido, sperm quality, serum testosterone level and testicular antioxidant enzyme activities
while increased the density of spermatozoa. |
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