Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines

A review of the current literature indicates that natural seaweeds are an excellent source of bioactive compounds with antioxidant, antimicrobial and antitumor properties. In the present study, 90% methanolic, 70% acetonic and aqueous extracts from Kappaphycus alvarezii (strains Crocodile, Giant and...

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Main Authors:	Tiek, Ying Lau, Delbora Fenny Vittal, Cassandra Yii Chew, Sze, Wilson Lym Yong, Thau
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2014
Online Access:	http://journalarticle.ukm.my/8150/ http://journalarticle.ukm.my/8150/ http://journalarticle.ukm.my/8150/1/11_Tiek_Ying_Lau.pdf

id	ukm-8150
recordtype	eprints
spelling	ukm-81502016-12-14T06:46:22Z http://journalarticle.ukm.my/8150/ Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines Tiek, Ying Lau Delbora Fenny Vittal, Cassandra Yii Chew, Sze Wilson Lym Yong, Thau A review of the current literature indicates that natural seaweeds are an excellent source of bioactive compounds with antioxidant, antimicrobial and antitumor properties. In the present study, 90% methanolic, 70% acetonic and aqueous extracts from Kappaphycus alvarezii (strains Crocodile, Giant and Brown) and Kappaphycus striatum were used to inhibit the growth of HeLa cell lines. MTS assay was carried out to determine the proliferation of HeLa cells in the presence of different seaweed extracts. Both 500 μg/mL of aqueous and methanolic extracts from K. striatum demonstrated highest anti-proliferative activity against HeLa cells with cell growth inhibition of 53.5 and 43.7%, respectively. Treatment with the aqueous extracts from three strains of K. alvarezii did not show any growth inhibition against HeLa cell lines. The acetonic extract of Kappaphycus seaweeds exhibited a very poor cell growth inhibition with inhibitory activity observed under the treatment of 300 to 500 μg/mL of K. alvarezii strain Brown only. Further studies are suggested to identify and purify the specific anti-tumoral compounds for potential use in cancer therapy. Universiti Kebangsaan Malaysia 2014-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8150/1/11_Tiek_Ying_Lau.pdf Tiek, Ying Lau and Delbora Fenny Vittal, and Cassandra Yii Chew, Sze and Wilson Lym Yong, Thau (2014) Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines. Sains Malaysiana, 43 (12). pp. 1895-1900. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	A review of the current literature indicates that natural seaweeds are an excellent source of bioactive compounds with antioxidant, antimicrobial and antitumor properties. In the present study, 90% methanolic, 70% acetonic and aqueous extracts from Kappaphycus alvarezii (strains Crocodile, Giant and Brown) and Kappaphycus striatum were used to inhibit the growth of HeLa cell lines. MTS assay was carried out to determine the proliferation of HeLa cells in the presence of different seaweed extracts. Both 500 μg/mL of aqueous and methanolic extracts from K. striatum demonstrated highest anti-proliferative activity against HeLa cells with cell growth inhibition of 53.5 and 43.7%, respectively. Treatment with the aqueous extracts from three strains of K. alvarezii did not show any growth inhibition against HeLa cell lines. The acetonic extract of Kappaphycus seaweeds exhibited a very poor cell growth inhibition with inhibitory activity observed under the treatment of 300 to 500 μg/mL of K. alvarezii strain Brown only. Further studies are suggested to identify and purify the specific anti-tumoral compounds for potential use in cancer therapy.
format	Article
author	Tiek, Ying Lau Delbora Fenny Vittal, Cassandra Yii Chew, Sze Wilson Lym Yong, Thau
spellingShingle	Tiek, Ying Lau Delbora Fenny Vittal, Cassandra Yii Chew, Sze Wilson Lym Yong, Thau Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines
author_facet	Tiek, Ying Lau Delbora Fenny Vittal, Cassandra Yii Chew, Sze Wilson Lym Yong, Thau
author_sort	Tiek, Ying Lau
title	Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines
title_short	Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines
title_full	Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines
title_fullStr	Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines
title_full_unstemmed	Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines
title_sort	antiproliferative potential of extracts from kappaphycus seaweeds on hela cancer cell lines
publisher	Universiti Kebangsaan Malaysia
publishDate	2014
url	http://journalarticle.ukm.my/8150/ http://journalarticle.ukm.my/8150/ http://journalarticle.ukm.my/8150/1/11_Tiek_Ying_Lau.pdf
first_indexed	2023-09-18T19:51:37Z
last_indexed	2023-09-18T19:51:37Z
_version_	1777406257718624256

Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines

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