Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study

Knowledge about the hemodynamic model that mediates synaptic activity and measured magnetic resonance signal is essential in understanding brain activation. Neural efficacy is a hemodynamic parameter that would change the evoked hemodynamic responses. In this work, brain activation and neural effica...

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Main Authors:	Ahmad Nazlim Yusoff, Ng, Sok Bee, Teng, Xin Ling, Aini Ismafairus Abd. Hamid
Format:	Article
Language:	English
Published:	penerbit ukm 2014
Subjects:	RA Public aspects of medicine
Online Access:	http://journalarticle.ukm.my/7480/ http://journalarticle.ukm.my/7480/ http://journalarticle.ukm.my/7480/1/Investigating_Brain_Activation.pdf

id	ukm-7480
recordtype	eprints
spelling	ukm-74802016-12-14T06:44:13Z http://journalarticle.ukm.my/7480/ Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study Ahmad Nazlim Yusoff, Ng, Sok Bee Teng, Xin Ling Aini Ismafairus Abd. Hamid, RA Public aspects of medicine Knowledge about the hemodynamic model that mediates synaptic activity and measured magnetic resonance signal is essential in understanding brain activation. Neural efficacy is a hemodynamic parameter that would change the evoked hemodynamic responses. In this work, brain activation and neural efficacy of the activated brain areas during simple addition task in two different backgrounds were studied using fMRI. The objectives were to determine the activated areas during the performance of arithmetic addition in quiet (AIQ) and noisy (AIN) background and to investigate the relationship between neural efficacy and height extent of activation for the respective areas. Eighteen healthy male participants performed simple arithmetic addition in quiet and in noise. Bilateral cerebellum, superior temporal gyrus (STG), temporal pole (TP) and supplementary motor area (SMA) were significantly (p < 0.05) activated during AIQ and AIN. Left middle frontal gyrus (L-MFG), right superior frontal gyrus (R-SFG), right superior orbital gyrus (R-SOG) and bilateral insula were more active in quiet as compared to in noise while the left middle cingulate cortex (L-MCC), left amygdala (L-AMG), right temporal pole (R-TP) and left cerebellum (L-CER) were more active in noise as compared to in quiet. The t value for most of the activated regions was found to be inversely proportional to the neural efficacy. Signifi cant (p < 0.05) negative relationship between t value and neural efficacy were found for R-STG and bilateral cerebellum during AIQ, while for AIN, similar relationships were found in R-CER, R-STG and R-TP. This study suggests that while being significantly activated, the hemodynamic responses of these brain regions could have been suppressed by the stimulus resulting in an intensity decrease with increasing neural efficacy. penerbit ukm 2014 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7480/1/Investigating_Brain_Activation.pdf Ahmad Nazlim Yusoff, and Ng, Sok Bee and Teng, Xin Ling and Aini Ismafairus Abd. Hamid, (2014) Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study. Jurnal Sains Kesihatan Malaysia, 12 (1). pp. 23-33. ISSN 1675-8161 http://ejournal.ukm.my/jskm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
topic	RA Public aspects of medicine
spellingShingle	RA Public aspects of medicine Ahmad Nazlim Yusoff, Ng, Sok Bee Teng, Xin Ling Aini Ismafairus Abd. Hamid, Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study
description	Knowledge about the hemodynamic model that mediates synaptic activity and measured magnetic resonance signal is essential in understanding brain activation. Neural efficacy is a hemodynamic parameter that would change the evoked hemodynamic responses. In this work, brain activation and neural efficacy of the activated brain areas during simple addition task in two different backgrounds were studied using fMRI. The objectives were to determine the activated areas during the performance of arithmetic addition in quiet (AIQ) and noisy (AIN) background and to investigate the relationship between neural efficacy and height extent of activation for the respective areas. Eighteen healthy male participants performed simple arithmetic addition in quiet and in noise. Bilateral cerebellum, superior temporal gyrus (STG), temporal pole (TP) and supplementary motor area (SMA) were significantly (p < 0.05) activated during AIQ and AIN. Left middle frontal gyrus (L-MFG), right superior frontal gyrus (R-SFG), right superior orbital gyrus (R-SOG) and bilateral insula were more active in quiet as compared to in noise while the left middle cingulate cortex (L-MCC), left amygdala (L-AMG), right temporal pole (R-TP) and left cerebellum (L-CER) were more active in noise as compared to in quiet. The t value for most of the activated regions was found to be inversely proportional to the neural efficacy. Signifi cant (p < 0.05) negative relationship between t value and neural efficacy were found for R-STG and bilateral cerebellum during AIQ, while for AIN, similar relationships were found in R-CER, R-STG and R-TP. This study suggests that while being significantly activated, the hemodynamic responses of these brain regions could have been suppressed by the stimulus resulting in an intensity decrease with increasing neural efficacy.
format	Article
author	Ahmad Nazlim Yusoff, Ng, Sok Bee Teng, Xin Ling Aini Ismafairus Abd. Hamid,
author_facet	Ahmad Nazlim Yusoff, Ng, Sok Bee Teng, Xin Ling Aini Ismafairus Abd. Hamid,
author_sort	Ahmad Nazlim Yusoff,
title	Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study
title_short	Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study
title_full	Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study
title_fullStr	Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study
title_full_unstemmed	Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study
title_sort	investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fmri study
publisher	penerbit ukm
publishDate	2014
url	http://journalarticle.ukm.my/7480/ http://journalarticle.ukm.my/7480/ http://journalarticle.ukm.my/7480/1/Investigating_Brain_Activation.pdf
first_indexed	2023-09-18T19:49:49Z
last_indexed	2023-09-18T19:49:49Z
_version_	1777406144388530176

Investigating brain activation and neural efficacy during simple arithmetic addition task in quiet and in noise: an fMRI study

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