Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters

Puffer fish, mainly from Tetraodontidae family known to possess a neurotoxin or tetrodotoxin (TTX) which can cause a puffer fish poisoning and adverse effect to human health. In current study, the tetrodotoxin (TTX) concentration in different tissues (liver, skin, muscle) of 14 species of puffer fis...

Full description

Bibliographic Details
Main Authors:	Mohd Nor Azman, A., Samsur, M., Othman, M.
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2014
Online Access:	http://journalarticle.ukm.my/7255/ http://journalarticle.ukm.my/7255/ http://journalarticle.ukm.my/7255/1/06_A._Mohd.pdf

id	ukm-7255
recordtype	eprints
spelling	ukm-72552016-12-14T06:43:32Z http://journalarticle.ukm.my/7255/ Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters Mohd Nor Azman, A. Samsur, M. Othman, M. Puffer fish, mainly from Tetraodontidae family known to possess a neurotoxin or tetrodotoxin (TTX) which can cause a puffer fish poisoning and adverse effect to human health. In current study, the tetrodotoxin (TTX) concentration in different tissues (liver, skin, muscle) of 14 species of puffer fish from Sabah and Sarawak waters were analysed and determined by application of liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Overall, extracted toxin for all specimens were shown to be toxic with result more than 0.2 μg/g as calculated based on TTX standard curve. Among the tissues, liver were found to be highest in TTX concentration (91.0 μg/g), followed by muscle (51.1 μg/g) and skin (6.87 μg/g). Moreover, TTX concentrations among puffer fish species were significantly differences (p<0.05) with Arothron immaculatus (275 μg/g) showed highest mean value, while the lowest value was detected in Lagocephalus lunaris (4.92 μg/g). From this finding, LC-MS/MS application could be a potential tools to determine the TTX and advisedly used as a procedure in screening of seafood for monitoring program. Furthermore, baseline data of TTX levels in selected puffer fish from the study could be important information and used as guideline in order to mitigate puffer fish poisoning cases especially in East Malaysia waters. Universiti Kebangsaan Malaysia 2014-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7255/1/06_A._Mohd.pdf Mohd Nor Azman, A. and Samsur, M. and Othman, M. (2014) Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters. Sains Malaysiana, 43 (7). pp. 1003-1011. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Puffer fish, mainly from Tetraodontidae family known to possess a neurotoxin or tetrodotoxin (TTX) which can cause a puffer fish poisoning and adverse effect to human health. In current study, the tetrodotoxin (TTX) concentration in different tissues (liver, skin, muscle) of 14 species of puffer fish from Sabah and Sarawak waters were analysed and determined by application of liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Overall, extracted toxin for all specimens were shown to be toxic with result more than 0.2 μg/g as calculated based on TTX standard curve. Among the tissues, liver were found to be highest in TTX concentration (91.0 μg/g), followed by muscle (51.1 μg/g) and skin (6.87 μg/g). Moreover, TTX concentrations among puffer fish species were significantly differences (p<0.05) with Arothron immaculatus (275 μg/g) showed highest mean value, while the lowest value was detected in Lagocephalus lunaris (4.92 μg/g). From this finding, LC-MS/MS application could be a potential tools to determine the TTX and advisedly used as a procedure in screening of seafood for monitoring program. Furthermore, baseline data of TTX levels in selected puffer fish from the study could be important information and used as guideline in order to mitigate puffer fish poisoning cases especially in East Malaysia waters.
format	Article
author	Mohd Nor Azman, A. Samsur, M. Othman, M.
spellingShingle	Mohd Nor Azman, A. Samsur, M. Othman, M. Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters
author_facet	Mohd Nor Azman, A. Samsur, M. Othman, M.
author_sort	Mohd Nor Azman, A.
title	Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters
title_short	Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters
title_full	Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters
title_fullStr	Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters
title_full_unstemmed	Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters
title_sort	distribution of tetrodotoxin among tissues of pufferfish from sabah and sarawak waters
publisher	Universiti Kebangsaan Malaysia
publishDate	2014
url	http://journalarticle.ukm.my/7255/ http://journalarticle.ukm.my/7255/ http://journalarticle.ukm.my/7255/1/06_A._Mohd.pdf
first_indexed	2023-09-18T19:49:10Z
last_indexed	2023-09-18T19:49:10Z
_version_	1777406103460511744

Distribution of tetrodotoxin among tissues of pufferfish from Sabah and Sarawak waters

Similar Items